Ethyl 2-bromopropionate

Product Name: Ethyl 2-bromopropionate
CAS No.: 535-11-5
Chemical Name: Ethyl 2-bromopropionate
Synonyms: ETHYL 2-BROMOPROPANOATE;DL-ETHYL 2-BROMOPROPIONATE;Ethyl 2-broMopropion;Ethyl-bromopropanoate;Ethyl 2-bromopropiote;Ethyl a-bromopropionate;ETHYL 2-BROMOPROPIONATE;Flurbiprofen impurity Ⅱ;Sacubitril Impurity 112;ethyl α-bromo propionoate
CBNumber: CB1329902
Molecular Formula: C5H9BrO2
Formula Weight: 181.03
MOL File: 535-11-5.mol

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Ethyl 2-bromopropionate Property

Melting point:: <25 °C
Boiling point:: 156-160 °C (lit.)
Density: 1.394 g/mL at 25 °C (lit.)
refractive index: n20/D 1.446(lit.)
Flash point:: 125 °F
storage temp.: Store below +30°C.
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Liquid
color: Clear colorless to very slightly yellow
Water Solubility: Immiscible
Merck: 14,3772
BRN: 773920
Dielectric constant: 9.3000000000000007
Stability:: Corrosive
InChIKey: ARFLASKVLJTEJD-UHFFFAOYSA-N
CAS DataBase Reference: 535-11-5(CAS DataBase Reference)
NIST Chemistry Reference: Propanoic acid, 2-bromo-, ethyl ester(535-11-5)
EPA Substance Registry System: Propanoic acid, 2-bromo-, ethyl ester (535-11-5)

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Safety

Hazard Codes: C,Xn
Risk Statements: 10-34-36/37/38-20/22
Safety Statements: 16-26-36/37/39-45-37/39
RIDADR: UN 2920 8/PG 2
WGK Germany: 3
RTECS: UA2451730
F: 8-19
TSCA: Yes
HazardClass: 3
PackingGroup: III
HS Code: 29159080
Toxicity: LD50 orally in Rabbit: 281 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E14551
Product name: Ethyl 2-bromopropionate
Purity: 99%
Packaging: 25g
Price: $36.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: E14551
Product name: Ethyl 2-bromopropionate
Purity: 99%
Packaging: 100g
Price: $66.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.20219
Product name: Ethyl 2-bromopropionate
Purity: for synthesis
Packaging: 250ML
Price: $108
Updated: 2022/05/15

TCI Chemical

Product number: B0646
Product name: Ethyl 2-Bromopropionate
Purity: >98.0%(GC)
Packaging: 25g
Price: $22
Updated: 2025/07/31

TCI Chemical

Product number: B0646
Product name: Ethyl 2-Bromopropionate
Purity: >98.0%(GC)
Packaging: 100g
Price: $49
Updated: 2025/07/31

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Ethyl 2-bromopropionate Chemical Properties,Usage,Production

Chemical Properties

clear colorless to very slightly yellow liquid

Uses

It?s an important organic intermediate can be used in agrochemical, pharmaceutical synthesis and dyestuff field.

Uses

Ethyl 2-Bromopropionate is an intermediate in the synthesis of organic compounds and pharmaceuticals.

Synthesis

64-17-5

598-72-1

535-11-5

General procedure for the synthesis of ethyl 2-bromopropionate from ethanol and 2-bromopropionic acid: (a) (ii) A solution of Et2O (5 mL) in 1 M HCl was added to a solution of EtOH (200 mL) in 2-bromopropionic acid (25 g). The reaction mixture was heated to reflux overnight. Upon completion of the reaction, the solvent was removed by rotary evaporator to give a yellow oily product, ethyl 2-bromopropionate, in a yield of 20.4 g (about 75% yield). The product was characterized by 1H NMR (500 MHz, CDCl3): δ 4.36 (q, J = 7.00 Hz, 1H), 4.24 (qd, J = 7.00 Hz, 2.69 Hz, 2H), 1.83 (d, J = 7.08 Hz, 3H), 1.31 (t, J = 7.20 Hz, 3H).

Purification Methods

Wash the ester with saturated aqueous Na2CO3 (three times), 50% aqueous CaCl2 (three times) and saturated aqueous NaCl (twice). Dry with MgSO4, CaCl2 or CaCO3, and distil it. [Beils

References

[1] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 3, p. 304 - 309
[2] Patent: WO2010/86613, 2010, A1. Location in patent: Page/Page column 39
[3] Journal of the American Chemical Society, 2014, vol. 136, # 50, p. 17662 - 17668
[4] Justus Liebigs Annalen der Chemie, 1879, vol. 197, p. 13
[5] Monatshefte fuer Chemie, 1881, vol. 2, p. 546

Ethyl 2-bromopropionate Preparation Products And Raw materials

Raw materials

Ethanol Propionic acid Bromopropionyl bromide 2-Bromopropionyl chloride Thionyl chloride

Preparation Products

4(3H)-Pyrimidinone, 5-methyl-2-(methylthio)- Oxiracetam 2-(2,4,5-TRICHLOROPHENOXY)PROPIONIC ACID 2-(2-OXO-2H-CHROMEN-7-YLOXY)-PROPIONIC ACID 4-CHLORO-5-METHYL-2-METHYLSULFANYL-PYRIMIDINE 5-METHYLPYRIMIDIN-4-OL 4-Hydroxy-5-methyl-2-mercaptopyrimidine

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Ethyl 2-bromopropionate Suppliers

Americas 1 Belgium 3 Canada 2 China 385 Europe 2 France 2 Germany 8 India 35 Israel 2 Japan 8 Slovakia 1 South Korea 1 Switzerland 3 The Netherlands 1 United Kingdom 13 United States 48 Global 515

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View Lastest Price from Ethyl 2-bromopropionate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Ethyl 2-bromopropionate 535-11-5
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-22

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Ethyl 2-bromopropionate 535-11-5
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-11-29

Hebei Yanxi Chemical Co., Ltd.

Product: Ethyl 2-bromopropionate 535-11-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-12

535-11-5, Ethyl 2-bromopropionateRelated Search:

ISOXADIFEN-ETHYL Tris(trimethylsilyl)phosphate DL-Ethyl 2-bromobutyrate Methyl acrylate Ethylparaben Ethyl chloroacetate Ethyl cyanoacetate Ethanol Ethyl propiolate Ethyl acrylate Ethyl phenylacetate Trinexapac-ethyl Ethyl acetate Diethyl 2-bromo-2-methylmalonate Ethyl 2,3-dibromopropionate DIETHYL DIBROMOMALONATE Ethyl bromodifluoroacetate Ethyl 2-bromoisobutyrate

2-bromo-propanoicaciethylester

Ethyl 2-broMopropion

Ethyl 2-broMopropionate 99%

Ethyl 2-bromopropiote

Ethyl-bromopropanoate

Propanoicacid,2-bromo-,ethylester

Propionic acid, 2-bromo-, ethyl ester

2-BROMOPROPANOIC ACID ETHYL ESTER

2-BROMOPROPIONIC ACID ETHYL ESTER

ALPHA-BROMOPROPIONIC ACID ETHYL ESTER

Ethyl (2S)-2-bromopropanoate

2-bromo-propionicaciethylester

Ethanol, 2-bromo, propanoate

Ethyl alpha-bromopropanoate

Ethyl dl-2-bromopropionate

ethylalpha-bromopropanoate

ethyl α-bromo propionoate

Ethyl a-bromopropionate

2-Bromopropanoic acid ethyl

2-Bromopropionic acid ethyl

DL-Ethyl 2-bromopropionate,99%

DL-Ethyl 2-broMopropionate, 99% 100GR

Ethyl 2-bromopropionate ,99%

DL-ETHYL 2-BROMOPROPIONATE

ETHYL ALPHA-BROMOPROPIONATE

ETHYL 2-BROMOPROPANOATE

ETHYL 2-BROMOPROPIONATE

α-Bromopropionic acid, ethyl ester

ETHYL A-BROMO PROPIONOATE

Flurbiprofen impurity Ⅱ

Ethyl 2-Bromopropionate &gt

ETHYL 2-BROMOPROPIONATE FOR SYNTHESIS

Alpha - ethyl bromopropionate

TIANFU CHEM 535-11-5 Ethyl 2-bromopropionate

Ethyl 2-bromopropionate, 98%

Sacubitril Impurity 112

535-11-5

CH3CHBrCOOC2H5

CH3CHBrCOC2H5

ESTER

Esters

Organic Building Blocks

Building Blocks

Carbonyl Compounds

C2 to C5

Esters

ACID BASED BROMO COMPOUNDS

C2 to C5

Carbonyl Compounds

Building Blocks

C2 to C5

Carbonyl Compounds

Chemical Synthesis

Organic Building Blocks

ester series