Ethyl 2-bromopropionate
- Product Name
- Ethyl 2-bromopropionate
- CAS No.
- 535-11-5
- Chemical Name
- Ethyl 2-bromopropionate
- Synonyms
- ETHYL 2-BROMOPROPANOATE;DL-ETHYL 2-BROMOPROPIONATE;Ethyl 2-broMopropion;Ethyl-bromopropanoate;Ethyl 2-bromopropiote;Ethyl a-bromopropionate;ETHYL 2-BROMOPROPIONATE;Flurbiprofen impurity Ⅱ;Sacubitril Impurity 112;ethyl α-bromo propionoate
- CBNumber
- CB1329902
- Molecular Formula
- C5H9BrO2
- Formula Weight
- 181.03
- MOL File
- 535-11-5.mol
Ethyl 2-bromopropionate Property
- Melting point:
- <25 °C
- Boiling point:
- 156-160 °C (lit.)
- Density
- 1.394 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.446(lit.)
- Flash point:
- 125 °F
- storage temp.
- Store below +30°C.
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Liquid
- color
- Clear colorless to very slightly yellow
- Water Solubility
- Immiscible
- Merck
- 14,3772
- BRN
- 773920
- Dielectric constant
- 9.3000000000000007
- Stability:
- Corrosive
- InChIKey
- ARFLASKVLJTEJD-UHFFFAOYSA-N
- CAS DataBase Reference
- 535-11-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Propanoic acid, 2-bromo-, ethyl ester(535-11-5)
- EPA Substance Registry System
- Propanoic acid, 2-bromo-, ethyl ester (535-11-5)
Safety
- Hazard Codes
- C,Xn
- Risk Statements
- 10-34-36/37/38-20/22
- Safety Statements
- 16-26-36/37/39-45-37/39
- RIDADR
- UN 2920 8/PG 2
- WGK Germany
- 3
- RTECS
- UA2451730
- F
- 8-19
- TSCA
- Yes
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29159080
- Toxicity
- LD50 orally in Rabbit: 281 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E14551
- Product name
- Ethyl 2-bromopropionate
- Purity
- 99%
- Packaging
- 25g
- Price
- $36.7
- Updated
- 2025/07/31
- Product number
- E14551
- Product name
- Ethyl 2-bromopropionate
- Purity
- 99%
- Packaging
- 100g
- Price
- $66.1
- Updated
- 2025/07/31
- Product number
- 8.20219
- Product name
- Ethyl 2-bromopropionate
- Purity
- for synthesis
- Packaging
- 250ML
- Price
- $108
- Updated
- 2022/05/15
- Product number
- B0646
- Product name
- Ethyl 2-Bromopropionate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $22
- Updated
- 2025/07/31
- Product number
- B0646
- Product name
- Ethyl 2-Bromopropionate
- Purity
- >98.0%(GC)
- Packaging
- 100g
- Price
- $49
- Updated
- 2025/07/31
Ethyl 2-bromopropionate Chemical Properties,Usage,Production
Chemical Properties
clear colorless to very slightly yellow liquid
Uses
It?s an important organic intermediate can be used in agrochemical, pharmaceutical synthesis and dyestuff field.
Uses
Ethyl 2-Bromopropionate is an intermediate in the synthesis of organic compounds and pharmaceuticals.
Synthesis
64-17-5
598-72-1
535-11-5
General procedure for the synthesis of ethyl 2-bromopropionate from ethanol and 2-bromopropionic acid: (a) (ii) A solution of Et2O (5 mL) in 1 M HCl was added to a solution of EtOH (200 mL) in 2-bromopropionic acid (25 g). The reaction mixture was heated to reflux overnight. Upon completion of the reaction, the solvent was removed by rotary evaporator to give a yellow oily product, ethyl 2-bromopropionate, in a yield of 20.4 g (about 75% yield). The product was characterized by 1H NMR (500 MHz, CDCl3): δ 4.36 (q, J = 7.00 Hz, 1H), 4.24 (qd, J = 7.00 Hz, 2.69 Hz, 2H), 1.83 (d, J = 7.08 Hz, 3H), 1.31 (t, J = 7.20 Hz, 3H).
Purification Methods
Wash the ester with saturated aqueous Na2CO3 (three times), 50% aqueous CaCl2 (three times) and saturated aqueous NaCl (twice). Dry with MgSO4, CaCl2 or CaCO3, and distil it. [Beils
References
[1] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 3, p. 304 - 309
[2] Patent: WO2010/86613, 2010, A1. Location in patent: Page/Page column 39
[3] Journal of the American Chemical Society, 2014, vol. 136, # 50, p. 17662 - 17668
[4] Justus Liebigs Annalen der Chemie, 1879, vol. 197, p. 13
[5] Monatshefte fuer Chemie, 1881, vol. 2, p. 546
Ethyl 2-bromopropionate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 2-bromopropionate Suppliers
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View Lastest Price from Ethyl 2-bromopropionate manufacturers
- Product
- Ethyl 2-bromopropionate 535-11-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-22
- Product
- Ethyl 2-bromopropionate 535-11-5
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-11-29
- Product
- Ethyl 2-bromopropionate 535-11-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-12