M-NIFEDIPINE

Product Name: M-NIFEDIPINE
CAS No.: 21881-77-6
Chemical Name: M-NIFEDIPINE
Synonyms: BAY-a-4339;M-NIFEDIPINE;Einecs 244-628-5;Nicardipine USP RC C;Benidipine impurity D;Nicardipine Impurity89;Nitrendipine Impurity 2;Nicardipine Impurity 03;Lercanidipine Impurity F;M-Nifedipine Impurity 11
CBNumber: CB5200528
Molecular Formula: C17H18N2O6
Formula Weight: 346.33
MOL File: 21881-77-6.mol

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M-NIFEDIPINE Property

Melting point:: 211-213℃
Boiling point:: 478.1±45.0 °C(Predicted)
Density: 1.271±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 2.71±0.70(Predicted)
color: Off-White to Light Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: N457015
Product name: m-Nifedipine
Packaging: 100mg
Price: $185
Updated: 2021/12/16

TRC

Product number: N457015
Product name: m-Nifedipine
Packaging: 1g
Price: $1455
Updated: 2021/12/16

Biosynth Carbosynth

Product number: ID57942
Product name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3.5-pyridinecarboxylic acid dimethyl ester
Packaging: 100mg
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: ID57942
Product name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3.5-pyridinecarboxylic acid dimethyl ester
Packaging: 250mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: 3185BA
Product name: M-Nifedipine
Packaging: 1g
Price: $80
Updated: 2021/12/16

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M-NIFEDIPINE Chemical Properties,Usage,Production

Uses

m-Nifedipine is an impurity of Nifedipine (N457000). Nicardipine USP Related Compound C.

Synthesis

99-61-6

105-45-3

21881-77-6

a) Synthesis of dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate A mixture of 75.5 g (0.50 mol) of 3-nitrobenzaldehyde, 116 g (1.00 mol) of methyl acetoacetate, and 55 mL (1.50 mol) of 28% ammonia solution was heated to reflux for 5 hours in 150 mL of methanol. After completion of the reaction, the precipitate was collected by filtration and the filter cake was purified by washing with hot anhydrous ethanol to give 133.5 g of yellow powdery product. The melting point (determined by Kofler's method) was 208°C. The yield was 77.2%.

References

[1] Synthetic Communications, 2012, vol. 42, # 3, p. 454 - 459
[2] Heteroatom Chemistry, 2006, vol. 17, # 4, p. 267 - 271
[3] Catalysis Communications, 2015, vol. 72, p. 63 - 67
[4] Patent: CN107141249, 2017, A. Location in patent: Paragraph 0134; 0135
[5] Monatshefte fur Chemie, 2006, vol. 137, # 1, p. 77 - 81

M-NIFEDIPINE Preparation Products And Raw materials

Raw materials

Preparation Products

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M-NIFEDIPINE Suppliers

China 111 India 6 Japan 1 United Kingdom 2 United States 14 Global 134

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
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Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
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Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
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Guangzhou Isun Pharmaceutical Co., Ltd

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TargetMol Chemicals Inc.

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ChemStrong Scientific Co.,Ltd

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Shanghai Kewel Chemical Co., Ltd.

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Nanjing XiZe Biotechnology CO., Ltd.

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Zhengzhou Gecko Scientific Inc.

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21881-77-6, M-NIFEDIPINERelated Search:

Nitrendipine nifedipine(uspgrade Nitrendipine Propyl Ester 5-(Ethoxycarbonyl)-2-(hydroxyMethyl-6-Methyl-4-(3-nitrophenyl)nicotinic Acid Nifedipine Impurity F NSC 136464 Dehydronitrendipine 3-benzyloxypyridine Benidipine Impurity 6 Benidipine Impurity 22 benidipine Benidipine Impurity Benidipine Impurity 23 Benidipine Impurity 15 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl Ester bis(1-benzylpiperidin-3-yl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Butanoic acid, 3-oxo-, 1-(phenylmethyl)-3-piperidinyl ester 1-Benzyl-3-piperidinol

DIMETHYL-2,6-DIMETHYL-4(3-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE

dimethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

DIMETHYL-2,6-DIMETHYL-4(3-NITROPHENYL)-1,4-DIHYDRPYRIDINE-3,5-DICARBOXYLATE(LERCANIDIPINE INTERMEDIATE)

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophen yl)-, dimethyl ester

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester

Dimethyl-2,6-dimethyl-4(3-nitrophenyl)-1,4-dihydrpyridine- 3-5-dicarboxylate

DIMETHYL-2,6-DIMETHYL-4(3-NITROPHENYL)-1,4-DIHYDRPYRIDINE-3-5-DICARBOXYLATE/LERCANIDIPINEOFINTERMEDIATER-1

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester

1,4-Dihydro-2,6-dimethyl-4β-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester

4-(3-Nitrophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylic acid dimethyl ester

4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid dimethyl ester

BAY-a-4339

Einecs 244-628-5

1,4-Dihydro-2,6-diMethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3,5-DiMethyl Ester

DiMethyl 4-(M-nitrophenyl)-2,6-diMethyl-1,4-dihydro-3,5- pyridinedicarboxylate

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3.5-pyridinecarboxylic acid dimethyl ester

M-NIFEDIPINE

Benidipine impurity D

Lercanidipine Impurity F

Nicardipine Hydrochloride EP impurity C

Nicardipine USP RC C

Nitrendipine Impurity 2

Nitrendipine EP Impurity B

M-Nifedipine Impurity 11

Lercanidipine Dimethyl Ester Impurity (Nitrendipine EP Impurity B)

Nicardipine Impurity 3（Nicardipine EP Impurity C）

Nicardipine dimethyl ester

Dimethyl 2,6-Dimethyl-4-(3-nitrophe

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3,5-dimethyl ester

Nicardipin Impurity USP RC-C

Nitrendipine EP Impurity B (Nicardipine Related Compound C/ Nicardipine Dimethyl Ester Analog/ m-Nifedipine/ Lercanidipine Dimethyl Ester Impurity)

NICARDIPINE DIMETHYL ESTER ANALOG

Nicardipine Related Compound C (Nicardipine Dimethyl Ester Analog/ m-Nifedipine/ Nitrendipine EP Impurity B)

Lercanidipine Dimethyl Ester Impurity (Nitrendipine EP Impurity B/ Nicardipine Related Compound C/ Nicardipine Dimethyl Ester Analog/ m-Nifedipine)

Nicardipine Impurity89

Nicardipine EP Impurity C

Nicardipine dimethyl esterQ: What is Nicardipine dimethyl ester Q: What is the CAS Number of Nicardipine dimethyl ester Q: What is the storage condition of Nicardipine dimethyl ester Q: What are the applications of Nicardipine dimethyl ester

Nicardipine Related Compound C

NICARDIPINE DIMETHYL ESTER ALOG

Benidipine Impurity D(Nitrendipine EP Impurity B)

Nicardipine EP Impurity C (Nicardipine USP Related Compound C, Nitrendipine EP Impurity B)

Nicardipine EP Impurity C（Nitrendipine EP Impurity B、Benidipine impurity D、Lercanidipine Impurity F）

Nicardipine Hydrochloride Impurity C

Nitrendipine Impurity 2 (Nitrendipine EP Impurity B)

Nicardipine EP Impurity 3

Nicardipine Impurity 03

NICARELATED COMPOUND IPINE DIMETHYL ESTER

21881-77-6

(intermediate of benidipine hcl)