ChemicalBook > CAS DataBase List > Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

Product Name
Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
CAS No.
1149-23-1
Chemical Name
Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Synonyms
diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;DILUDINE;hantzschester;ethidine;1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER;1,4-dihydro-2,6-dimethyL;rr116;etidin;diethone;DIETHANE
CBNumber
CB4757520
Molecular Formula
C13H19NO4
Formula Weight
253.29
MOL File
1149-23-1.mol
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Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Property

Melting point:
178-183 °C(lit.)
Boiling point:
351.8±42.0 °C(Predicted)
Density 
1.104±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in organic solvents.
pka
3.50±0.70(Predicted)
form 
Solid
color 
Yellow
λmax
374nm(EtOH)(lit.)
InChI
InChI=1S/C13H19NO4/c1-5-17-12(15)10-7-11(13(16)18-6-2)9(4)14-8(10)3/h14H,5-7H2,1-4H3
InChIKey
LJXTYJXBORAIHX-UHFFFAOYSA-N
SMILES
C1(C)NC(C)=C(C(OCC)=O)CC=1C(OCC)=O
CAS DataBase Reference
1149-23-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
2
RTECS 
US7970100
HS Code 
29333990
Toxicity
LD50 oral in dog: > 12gm/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
120227
Product name
Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Purity
95%
Packaging
1G
Price
$73.8
Updated
2024/03/01
Sigma-Aldrich
Product number
120227
Product name
Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Purity
95%
Packaging
10G
Price
$455
Updated
2024/03/01
Sigma-Aldrich
Product number
120227
Product name
Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Purity
95%
Packaging
50G
Price
$1870
Updated
2024/03/01
TCI Chemical
Product number
D3775
Product name
Diethyl 1,4-Dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$24
Updated
2024/03/01
TCI Chemical
Product number
D3775
Product name
Diethyl 1,4-Dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Purity
>98.0%(HPLC)(N)
Packaging
25g
Price
$59
Updated
2024/03/01
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Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Chemical Properties,Usage,Production

Chemical Properties

Light green solid

Uses

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate is a hydrogen source in conjugate reduction and organocatalytic reductive amination. It is used as a hydrogen source in organocatalytic reductive amination and conjugate reduction.

Uses

3,5-Dicarboethoxy-2,6-dimethyl-1,4-dihydropyridine is a dihydropyridine derivative that have been tested for antimicrobial activities.

Application

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate (DTP) was used to study the mechanism of electrochemical oxidation of DTP in ethanol/water solutions on a glassy carbon electrode.

Hazard

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Toxicology

rat LD50 intraperitoneal >16 gm/kg
mouse LD50 oral >32 gm/kg
mouse LD50 intraperitoneal >30 gm/kg
dog LD50 oral >12 gm/kg

Synthesis

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate is prepared by the reaction of formaldehyd and ethyl acetoacetate in the presence of an inert gas.

Purification Methods

recrystallization from EtOH or flash chromatography with petroleum/ethyl acetate (7:3)

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Preparation Products And Raw materials

Raw materials

Ethanol Hexamethylenetetramine

Preparation Products

Benidipine Nicardipine Glutaraldehyde Imazosulfuron Nilvadipine
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Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Suppliers

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View Lastest Price from Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Dihydropyridine 1149-23-1
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-03
Henan Suikang Pharmaceutical Co.,Ltd.
Product
Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 1149-23-1
Price
US $0.00/kg
Min. Order
25kg
Purity
99.0%
Supply Ability
1tons
Release date
2024-04-26
Hebei Mujin Biotechnology Co.,Ltd
Product
Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 1149-23-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-21

1149-23-1, Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylateRelated Search:

Dimethyl carbonate Dacthal Ethylene glycol diethyl ether Pyridine hydrobromide 2,6-Lutidine Dimethyl phthalate Dimethyl sulfate N,N-Dimethylformamide Dimethyl fumarate Quinolinic acid Dimethyl sulfoxide Dimethyl disulfide 2,5-PYRIDINEDICARBOXYLIC ACID Mefenpyr-diethyl Diethyl oxalate Diethyl malonate Dimethyl ether ETHANE

  • DILUDINE
  • DIETHYL 2,6-DIMETHYL-1,4-DIHYDRO-3,5-PYRIDINEDICARBOXYLATE
  • DIETHYL 2,6-DIMETHYL-1,4-DIHYDROPYRIDINEDICARBOXYLATE
  • DIETHYL 1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE
  • AURORA 4780
  • 3,5-DICARBETHOXY-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE
  • 3,5-BIS(CARBOETHOXY)-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE
  • 2,6-DIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID DIETHYL ESTER
  • 2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine
  • 1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER
  • RARECHEM AQ NN 0171
  • 5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-diethylester
  • diethone
  • ethidine
  • etidin
  • hantzsch’sdihydropyridine
  • hantzschester
  • rr116
  • 1,4-Dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Diethyl Ester Hantzsch Ester
  • 1,4-diethyl-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • 3,5-Dicarboethoxy-2,6-dimethyl-1,4-dihydropyridine
  • Diethyl 1,4-dihydro-2,6-diMethyl-3,5- pyridinedicarboxylat
  • Diethyl 1,4-dihydro-2,6-diMethyl-3,5-pyridinedicarboxylate, 98%, 98%
  • 1,4-dihydro-2,6-dimethyL
  • Diethyl1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate,98%
  • Two hydropyridine
  • 3,5-diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • Dihy**yridine
  • 1,4-diethyl-2,6-dimethyl-4H-pyridine-3,5-dicarboxylate
  • Diethyl-1,4-dihydro-2,6-dimethylpyridin-3,5-dicarboxylat
  • DIETHYL1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE(DILUDIN)
  • diethyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate
  • Dihydropyridinum
  • Dihydropyride
  • 2,6-Dimethyl-3.5-Diethylester-1.4-Diludine
  • DILOXANIDEFUROATE
  • DIETHANE
  • Diethyl-1,4-dihydro-2,6-diMethyl-3,5-pyridine carboxylate
  • 1,4-Dihydro-2,6-dimethylpyridine-3,5-dicarboxylic acid diethyl ester
  • 1.4-dihydro-2.6-dimethyl-3.5-pyridinedicarboxylate
  • diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
  • Diethyl 1,4-dihydro-3,5-pyridinecarboxylate, 95%
  • Diethyl 1,4-dihydro-
  • Lilium pumilum DC.
  • Diethyl1,4-Dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate&gt
  • -3,5-pyridinedicarboxyL
  • Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate USP/EP/BP
  • 4-dihydro-2
  • 5-pyridinedicarboxylate
  • 6-dimethyl-3
  • Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxy
  • Feed Medication Additives
  • Diethyl 1,4-dihydro-3,5-pyridinecarboxylate, 95%,
  • Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarbox
  • Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarbo
  • 1,4 Dihydro, 3,5,di-carboethoxy 2,6 dimethyl pyridine
  • Aminocaproic Acid Impurity 16