ChemicalBook > CAS DataBase List > Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

Product Name: Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
CAS No.: 1149-23-1
Chemical Name: Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Synonyms: diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;DILUDINE;hantzschester;ethidine;1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER;1,4-dihydro-2,6-dimethyL;rr116;etidin;diethone;DIETHANE
CBNumber: CB4757520
Molecular Formula: C13H19NO4
Formula Weight: 253.29
MOL File: 1149-23-1.mol

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Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Property

Melting point:: 178-183 °C(lit.)
Boiling point:: 351.8±42.0 °C(Predicted)
Density: 1.104±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in organic solvents.
pka: 3.50±0.70(Predicted)
form: Solid
color: Yellow
λmax: 374nm(EtOH)(lit.)
InChI: InChI=1S/C13H19NO4/c1-5-17-12(15)10-7-11(13(16)18-6-2)9(4)14-8(10)3/h14H,5-7H2,1-4H3
InChIKey: LJXTYJXBORAIHX-UHFFFAOYSA-N
SMILES: C1(C)NC(C)=C(C(OCC)=O)CC=1C(OCC)=O
CAS DataBase Reference: 1149-23-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 2
RTECS: US7970100
HS Code: 29333990
Toxicity: LD50 oral in dog: > 12gm/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 120227
Product name: Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Purity: 95%
Packaging: 1G
Price: $76.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 120227
Product name: Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Purity: 95%
Packaging: 10G
Price: $469
Updated: 2025/07/31

Sigma-Aldrich

Product number: 120227
Product name: Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Purity: 95%
Packaging: 50G
Price: $1930
Updated: 2025/07/31

TCI Chemical

Product number: D3775
Product name: Diethyl 1,4-Dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $24
Updated: 2025/07/31

TCI Chemical

Product number: D3775
Product name: Diethyl 1,4-Dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $59
Updated: 2025/07/31

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Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Chemical Properties,Usage,Production

Chemical Properties

Light green solid

Uses

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate is a hydrogen source in conjugate reduction and organocatalytic reductive amination. It is used as a hydrogen source in organocatalytic reductive amination and conjugate reduction.

Uses

3,5-Dicarboethoxy-2,6-dimethyl-1,4-dihydropyridine is a dihydropyridine derivative that have been tested for antimicrobial activities.

Application

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate (DTP) was used to study the mechanism of electrochemical oxidation of DTP in ethanol/water solutions on a glassy carbon electrode.

Hazard

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Toxicology

rat LD50 intraperitoneal >16 gm/kg
mouse LD50 oral >32 gm/kg
mouse LD50 intraperitoneal >30 gm/kg
dog LD50 oral >12 gm/kg

Synthesis

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate is prepared by the reaction of formaldehyd and ethyl acetoacetate in the presence of an inert gas.

Purification Methods

recrystallization from EtOH or flash chromatography with petroleum/ethyl acetate (7:3)

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Preparation Products And Raw materials

Raw materials

Ethanol Hexamethylenetetramine

Preparation Products

Benidipine Nicardipine Glutaraldehyde Imazosulfuron Nilvadipine

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View Lastest Price from Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate manufacturers

Wuhan JiyunZen Tech Co., Ltd.

Product: Diethyl 1149-23-1
Price: US $5.00-0.50/KG
Min. Order: 0.10000000149011612KG
Purity: 99% hplc
Supply Ability: 5000kg
Release date: 2025-06-12

Henan Suikang Pharmaceutical Co.,Ltd.

Product: Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 1149-23-1
Price: US $0.00/kg
Min. Order: 25kg
Purity: 99.0%
Supply Ability: 1tons
Release date: 2024-04-26

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Dihydropyridine 1149-23-1
Price: US $180.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-06-03

1149-23-1, Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylateRelated Search:

Dimethyl carbonate Dacthal Ethylene glycol diethyl ether Pyridine hydrobromide 2,6-Lutidine Dimethyl phthalate Dimethyl sulfate N,N-Dimethylformamide Quinolinic acid Dimethyl fumarate Dimethyl sulfoxide Dimethyl disulfide 2,5-PYRIDINEDICARBOXYLIC ACID Mefenpyr-diethyl Diethyl oxalate Diethyl malonate Dimethyl ether ETHANE

DILUDINE

DIETHYL 2,6-DIMETHYL-1,4-DIHYDRO-3,5-PYRIDINEDICARBOXYLATE

DIETHYL 2,6-DIMETHYL-1,4-DIHYDROPYRIDINEDICARBOXYLATE

DIETHYL 1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE

AURORA 4780

3,5-DICARBETHOXY-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE

3,5-BIS(CARBOETHOXY)-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE

2,6-DIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID DIETHYL ESTER

2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine

1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER

RARECHEM AQ NN 0171

5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-diethylester

diethone

ethidine

etidin

hantzsch’sdihydropyridine

hantzschester

rr116

1,4-Dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Diethyl Ester Hantzsch Ester

1,4-diethyl-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate

3,5-Dicarboethoxy-2,6-dimethyl-1,4-dihydropyridine

Diethyl 1,4-dihydro-2,6-diMethyl-3,5- pyridinedicarboxylat

Diethyl 1,4-dihydro-2,6-diMethyl-3,5-pyridinedicarboxylate, 98%, 98%

1,4-dihydro-2,6-dimethyL

Diethyl1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate,98%

Two hydropyridine

3,5-diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Dihy**yridine

1,4-diethyl-2,6-dimethyl-4H-pyridine-3,5-dicarboxylate

Diethyl-1,4-dihydro-2,6-dimethylpyridin-3,5-dicarboxylat

DIETHYL1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE(DILUDIN)

diethyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate

Dihydropyridinum

Dihydropyride

2,6-Dimethyl-3.5-Diethylester-1.4-Diludine

DILOXANIDEFUROATE

DIETHANE

Diethyl-1,4-dihydro-2,6-diMethyl-3,5-pyridine carboxylate

1,4-Dihydro-2,6-dimethylpyridine-3,5-dicarboxylic acid diethyl ester

1.4-dihydro-2.6-dimethyl-3.5-pyridinedicarboxylate

diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester

Diethyl 1,4-dihydro-3,5-pyridinecarboxylate, 95%

Diethyl 1,4-dihydro-

Lilium pumilum DC.

Diethyl1,4-Dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate&gt

-3,5-pyridinedicarboxyL

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate USP/EP/BP

4-dihydro-2

5-pyridinedicarboxylate

6-dimethyl-3

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxy

Feed Medication Additives

Diethyl 1,4-dihydro-3,5-pyridinecarboxylate, 95%,

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarbox

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarbo

1,4 Dihydro, 3,5,di-carboethoxy 2,6 dimethyl pyridine

Aminocaproic Acid Impurity 16