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4-Hydroxypyridine

Product Name
4-Hydroxypyridine
CAS No.
626-64-2
Chemical Name
4-Hydroxypyridine
Synonyms
PYRIDIN-4-OL;4-PYRIDINOL;4HYDROXYPRIDINE;4-Hydroxypyride;1H-Pyridin-4-ol;Compound Fr14055;4-HYDROXYPYRIDINE; 4-Hydroxypyridone ;TIMTEC-BB SBB000030;4-hydroxyl pyridine
CBNumber
CB6303828
Molecular Formula
C5H5NO
Formula Weight
95.1
MOL File
626-64-2.mol
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4-Hydroxypyridine Property

Melting point:
150-151 °C (lit.)
Boiling point:
230-235 °C/12 mmHg (lit.)
Density 
1.1418 (rough estimate)
refractive index 
1.5939 (estimate)
Flash point:
221 °C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Powder or Chunks
pka
3.2(at 20℃)
color 
Beige to light brown
Water Solubility 
Soluble
BRN 
105800
InChIKey
GCNTZFIIOFTKIY-UHFFFAOYSA-N
LogP
-1.300 (est)
CAS DataBase Reference
626-64-2(CAS DataBase Reference)
NIST Chemistry Reference
4-Pyridinol(626-64-2)
EPA Substance Registry System
4-Pyridinol (626-64-2)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-41-37/38-22
Safety Statements 
26-36-37/39-39
WGK Germany 
3
RTECS 
UU7701450
F 
3-8-10
Hazard Note 
Harmful/Irritant
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
120618
Product name
4-Hydroxypyridine
Purity
95%
Packaging
25g
Price
$66.8
Updated
2024/03/01
Sigma-Aldrich
Product number
120618
Product name
4-Hydroxypyridine
Purity
95%
Packaging
100g
Price
$184
Updated
2024/03/01
Sigma-Aldrich
Product number
CDS013613
Product name
4-hydroxypyridine
Purity
AldrichCPR
Packaging
1G
Price
$68.1
Updated
2023/06/20
TCI Chemical
Product number
H0332
Product name
4-Hydroxypyridine
Purity
>99.0%(GC)
Packaging
25g
Price
$80
Updated
2024/03/01
Alfa Aesar
Product number
A14586
Product name
4-Hydroxypyridine, 97%
Packaging
25g
Price
$54.65
Updated
2024/03/01
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4-Hydroxypyridine Chemical Properties,Usage,Production

Description

4-Hydroxypyridine, available from pyridylpyridinium chloride hydrochloride, is the substrate for diodone and its n-propyl ester, propyliodone. 4-Hydroxypyridine (4-HP) is a non-nucleophilic analog of the product phenol found to bind specifically to and stabilize the aminoacrylate intermediate. When 4-HP is added to Tyrosine phenol-lyase (TPL) reactions, an absorption peak at 340 nm is observed. The formation of the 340 nm peak correlates with the decay of the quinonoid intermediate peak at 505 nm, with a clean isosbestic point, and the observed rate constants show an inverse dependence on the concentration of 4-HP. These results confirm that the observed peak at 340 nm is due to the formation of the amino acrylate intermediate[1-2].

Chemical Properties

Beige crystalline powder

Uses

4-Hydroxypyridine was used in the synthesis of (Ag3MoO3F3) (Ag3MoO4)Cl by hydro(solvato)thermal methods. It was used as model compound to study the natural photodegradation of representative aquatic environmental contaminants.

Definition

ChEBI: A monohydroxypyridine that is pyridine in which the hydrogen at position 4 has been replaced by a hydroxy group.

Purification Methods

Crystallise 4-pyridone from H2O or wet CHCl3 as the monohydrate. It loses H2O on drying in vacuo over H2SO4. Store it over KOH because it is hygroscopic.[Beilstein 21 III/IV 446, 21/7 V 152.]

References

[1] Yates, F. S. “2.09 – Pyridines and their Benzo Derivatives: (vi) Applications.”Comprehensive Heterocyclic Chemistry 2 (1984): 511-524.
[1] Robert S Phillips, Olivia Bauer. “Characterization of aminoacrylate intermediates of pyridoxal-5’-phosphate dependent enzymes.” Methods in enzymology 685 (2023): 199–224.

4-Hydroxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-DICHLORO-5-NITROPYRIDINE 3-AMINO-4-METHOXYPYRIDINE 3,4-Diaminopyridine 4-Dimethylaminopyridine
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4-Hydroxypyridine Suppliers

Americas 1 Belgium 1 Canada 1 China 459 Europe 4 Germany 5 India 59 Ireland 1 Japan 4 Jordan 1 Russia 1 Slovakia 1 South Korea 2 Switzerland 3 The Netherlands 2 Ukraine 1 United Kingdom 10 United States 55 USA 1 Global 612
National Chemical Company (NCC)
Tel
--
Fax
--
Email
info@ncc.ie
Country
Ireland
ProdList
302
Advantage
58
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View Lastest Price from 4-Hydroxypyridine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-Hydroxypyridine 626-64-2
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kgs
Release date
2021-11-10
Hebei Weibang Biotechnology Co., Ltd
Product
4-Hydroxypyridine 626-64-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-11
Shanghai UCHEM Inc.
Product
4-Hydroxypyridine 626-64-2
Price
US $225.00/kg
Min. Order
1kg
Purity
0.97
Supply Ability
25kg
Release date
2023-11-17

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