Boc-L-beta-Homoproline

Product Name: Boc-L-beta-Homoproline
CAS No.: 56502-01-3
Chemical Name: Boc-L-beta-Homoproline
Synonyms: Boc-b-HoPro-OH;Boc-β-HoPro-OH;BOC-BETA-HPRO-OH;Boc-β-HomoPro-OH;Boc-p-HomoPro-OH;BOC-BETA-HOPRO-OH;BOC-BETA3-HOMOPRO;BOC-PRO-(C*CH2)OH;boc-β3-homopro-oh;BOC-B-HOMOPROLINE
CBNumber: CB5169171
Molecular Formula: C11H19NO4
Formula Weight: 229.27
MOL File: 56502-01-3.mol

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Boc-L-beta-Homoproline Property

Melting point:: 98 °C
Boiling point:: 357.4±15.0 °C(Predicted)
Density: 1.151±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 4.56±0.10(Predicted)
form: Crystalline Powder
color: White to off-white
BRN: 478306
InChI: InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-6-4-5-8(12)7-9(13)14/h8H,4-7H2,1-3H3,(H,13,14)/t8-/m0/s1
InChIKey: GDWKIRLZWQQMIE-QMMMGPOBSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC[C@H]1CC(O)=O
CAS DataBase Reference: 56502-01-3(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 14982
Product name: Boc-β3-Homopro-OH
Purity: ≥98.0% (TLC)
Packaging: 1g
Price: $85
Updated: 2023/06/20

TRC

Product number: B200855
Product name: Boc-L-β-homoproline
Packaging: 1g
Price: $130
Updated: 2021/12/16

Activate Scientific

Product number: AS35813
Product name: (S)-2-(1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)acetic acid
Purity: 98+% ee
Packaging: 1g
Price: $139
Updated: 2021/12/16

Chem-Impex

Product number: 12782
Product name: Boc-L-β-homoproline,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 5G
Price: $229.6
Updated: 2021/12/16

ChemPep

Product number: 181642
Product name: Boc-β-Homo-Pro-OH
Packaging: 1g
Price: $277
Updated: 2021/12/16

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Boc-L-beta-Homoproline Chemical Properties,Usage,Production

Uses

Building block for necine alkaloids.

Uses

Boc-L-beta-homoproline is an amino acid derivative which is a reagent in the synthesis of dihydroisoxazole inhbitors of human transglutaminase 2, an enzyme that catalyzes the modification of glutamine residues. This enzyme has been implicated in numerous inflmmatory, fibrotic and other diseases.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

88790-37-8

56502-01-3

General procedure for the synthesis of (S)-2-(2-pyrrolidinyl)acetic acid from methyl (S)-2-(2-pyrrolidinyl)acetate: tert-butyl (2S)-2-(2-methoxy-2-oxoethyl)-1-pyrrolidinecarboxylate (8.35 g, 34.3 mmol) was dissolved in 150 mL of methanol. 50 mL of 1 M aqueous sodium hydroxide solution was added and the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solution was concentrated under reduced pressure to about 100 mL. The concentrated solution was added to 300 mL of water and extracted twice with ether (2 x 100 mL). The aqueous phase was acidified to pH 2 with 12N hydrochloric acid and extracted with ether twice more (2 x 100 mL). The aqueous layer was saturated with saturated sodium chloride solution and then extracted with ether a third time (100 mL). All organic layers were combined, washed sequentially with water and saturated sodium chloride solution, and then dried with anhydrous magnesium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to afford the title compound (S)-2-(1-tert-butoxycarbonyl-2-pyrrolidinyl)acetic acid as a white solid (7.28 g, 31.7 mmol, 92.6% yield). peaks, 4H), 1.48 (single peak, 9H) ppm.

References

[1] Patent: WO2003/76440, 2003, A1. Location in patent: Page/Page column 140
[2] Journal of Organic Chemistry, 2005, vol. 70, # 22, p. 8730 - 8733
[3] Organic and Biomolecular Chemistry, 2003, vol. 1, # 22, p. 3977 - 3988
[4] Tetrahedron Letters, 1997, vol. 38, # 20, p. 3609 - 3610

Boc-L-beta-Homoproline Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate Triethylamine BOC-L-Prolinol Tosyl chloride Dichloromethane POTASSIUM CYANIDE 4-Dimethylaminopyridine

Preparation Products

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Boc-L-beta-Homoproline Suppliers

Belgium 2 China 136 France 1 Germany 6 India 5 Japan 2 Switzerland 1 The Netherlands 1 United Kingdom 7 United States 36 Global 197

SINO High Goal Chemical Technology Co., Ltd.

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J & K SCIENTIFIC LTD.

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Shanghai HC Biotech Co., Ltd

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ITIC MEDCHEM(SUZHOU) CO.,LTD.

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Alfa Aesar

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Ark Pharm, Inc.

Tel: 847-367-3680
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Energy Chemical

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Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
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Suzhou haiyu Biochem Industrial Co., LTD

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View Lastest Price from Boc-L-beta-Homoproline manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Boc-L-beta-Homoproline 56502-01-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-12

Career Henan Chemical Co

Product: Boc-L-beta-Homoproline 56502-01-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-22

56502-01-3, Boc-L-beta-HomoprolineRelated Search:

L-PROLINE-(4-3H(N)) Povidone iodine cis-4-Hydroxy-L-proline tert-Butanol BOC-L-Proline N-Methyl-2-pyrrolidone Polyvinylpyrrolidone N-Vinyl-2-pyrrolidone Ethyl 2-(Chlorosulfonyl)acetate Ascoric Acid Acetic anhydride Phenylacetic acid METHYL-2-PYRROLIDONE Carbonyl iron powder BOC-D-BETA-HOMOPROLINE 3-TERT-BUTOXYCARBONYLAMINO-HEXANOIC ACID (S)-(1-Boc-5-oxo-pyrrolidin-2-yl)acetic acid (S)-2-(2-PYRROLIDINYL)ACETIC ACID

N-BOC-(2S)-PYRR(2-CHCOOH)

N-BETA-T-BUTOXYCARBONYL-L-BETA-HOMOPROLINE

(S)-2-(1-BOC-2-PYRROLIDINYL)ACETIC ACID

(S)-N-T-BUTOXYCARBONYL-PYRROLIDINE-2-ACETIC ACID

BOC-L-BETA-HOMOPROLINE

BOC-BETA3-HOMOPRO

BOC-BETA-HOPRO-OH

BOC-BETA-HOMOPROLINE

BOC-BETA-HOMOPRO-OH

BOC-PRO-(C*CH2)OH

Boc-L-beta(3)-homoproline

Boc-L-b-homoproline

boc-β3-homopro-oh

BOC-B-HOMOPROLINE

Boc-L-β-Homo-Pro-OH

Boc-L-beta-HPro-OH

N-beta-(t-Butyloxycarbonyl)-L-homoproline, (S)-N-t-Butyloxycarbonyl-2-(pyrrolidin-2-yl)acetic acid

Boc-b-HoPro-OH

2-[(2S)-(1-tert-Butoxycarbonyl)pyrrolidin-2-yl]acetic acid

(S)-2-(1-Boc-2-pyrrolidinyl)acetic acid, Boc-L-β3-homoproline

Boc-beta-HoPro-OH 56502-

Boc-L-β-homoproline≥ 98% (NMR)

2-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]acetic acid

BOC-BETA-HPRO-OH

(S)-2-(carboxymethyl)pyrrolidinium chloride

Boc-L-beta-homo-Pro

(S)-2-Carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Boc-L-β-homoproline ,98%

(S)-2-(1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)acetic acid

2-Pyrrolidineacetic acid, 1-[(1,1-diMethylethoxy)carbonyl]-, (2S)-

(S)-N-t-Butyloxycarbonyl-2-(pyrrolidin-2-yl)acetic acid

N-beta-(t-Butyloxycarbonyl)-L-homoproline

Boc-β-HomoPro-OH

Boc-beta3-Homopro-OH

Boc-L-β-Homoproline

Boc-p-HomoPro-OH

Boc-L-beta-Homoproline USP/EP/BP

Boc-β-HoPro-OH

Methyl(2S)-pyrrolidin-2-ylacetate Cas:53912-83-7

(2S)-1-tert-butoxycarbonyl-2-carboxymethylpyrrolidine

Boc-β<sup>3</sup>-Homopro-OH

(S)-2-(1-Bocpyrrolidin-2-yl)-acetic acid

56502-01-3

C11H19N1O4

Specialty Synthesis

Peptide Synthesis

Unnatural Amino Acid Derivatives

Beta-Amino Acids

β-Homo Amino Acids

Beta amino acids