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4-TRIFLUOROMETHYL-N-METHYLANILINE 97

Product Name
4-TRIFLUOROMETHYL-N-METHYLANILINE 97
CAS No.
22864-65-9
Chemical Name
4-TRIFLUOROMETHYL-N-METHYLANILINE 97
Synonyms
Fluoxetine impurity FXT;Fluoxetine impurity FXT-V;4-(Trifluoromethyl)-N<;N-Methyl-4-(trifluoromethyl);4-(Methylamino)benzotrifluoride;N-Methyl-p-trifluoromethylaniline;4-(Methylamino)benzotrifluoride 98%;4-TRIFLUOROMETHYL-N-METHYLANILINE 97;4-(Trifluoromethyl)-N-methylaniline 97%;N-Methyl-4-(trifluoromethyl)-benzenamine
CBNumber
CB3498752
Molecular Formula
C8H8F3N
Formula Weight
175.15
MOL File
22864-65-9.mol
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4-TRIFLUOROMETHYL-N-METHYLANILINE 97 Property

Boiling point:
105-106 °C/20 mmHg (lit.)
Density 
1.2394 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.4888(lit.)
Flash point:
210 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
clear liquid
pka
2.58±0.12(Predicted)
color 
Colorless to Light orange to Yellow
InChIKey
UTUYWZJPVLDHJJ-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xn
Risk Statements 
22-43
Safety Statements 
36/37
WGK Germany 
3
HS Code 
2921430090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
631051
Product name
4-(Trifluoromethyl)-N-methylaniline
Purity
97%
Packaging
1g
Price
$235
Updated
2025/07/31
Sigma-Aldrich
Product number
631051
Product name
4-(Trifluoromethyl)-N-methylaniline
Purity
97%
Packaging
5g
Price
$951
Updated
2025/07/31
TCI Chemical
Product number
M2774
Product name
N-Methyl-4-(trifluoromethyl)aniline
Packaging
1G
Price
$102
Updated
2025/07/31
TCI Chemical
Product number
M2774
Product name
N-Methyl-4-(trifluoromethyl)aniline
Packaging
5G
Price
$258
Updated
2025/07/31
TRC
Product number
T791410
Product name
4-(Trifluoromethyl)-N-methylaniline
Packaging
5g
Price
$140
Updated
2021/12/16
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4-TRIFLUOROMETHYL-N-METHYLANILINE 97 Chemical Properties,Usage,Production

Uses

4-(Trifluoromethyl)-N-methylaniline is used in the synthesis of Tasquinimod (T007820), an orally active antiangiogenic agent which may inhibit HDAC4 signalling. This affects cancer cell survival thus making this compound and anti-cancer agent.

Synthesis

455-14-1

616-38-6

22864-65-9

GENERAL PROCEDURE: The selective N-monomethylation reaction was carried out in a Vapourtec E-Series continuous flow system equipped with a high temperature tubular reactor (10 mL, stainless steel, 0.03 inch ID, Figure 2) and a membrane back pressure regulator (Zaiput). In an oven, stock solutions of p-trifluoromethylaniline (20 mmol, 1.0 eq, 2M), dimethyl carbonate (DMC, 5.05 mL, 60 mmol, 3.0 eq, 6M), and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU, 4.47 mL, 30 mmol, 1.5 eq, 3M) were prepared in dry 10 mL volumetric flask using N-methylpyrrolidone (NMP) as solvent. The solution was transferred to a threaded vial with a septum cap and the reagent was pumped directly from the vial. After the high-temperature coil reactor was heated to 250 °C, the reactant solution was pumped into the system using a peristaltic pump (Vapourtec V-3) at a flow rate of 0.277 mL/min (residence time 12 min). The solutions were mixed through a cross-mixer (0.4-inch ID) and into a high-temperature coil reactor. After flowing through the reactor, the reactants are cooled through a small section of stainless steel tubing and subsequently exit the system through a back pressure regulator (Note: PFA fittings should not be used at the outlet as they can deform at high temperatures and cause the system to leak. This system utilizes stainless steel connectors and tubing (12 inches)). The flow system was equilibrated for 18 minutes and the product stream was collected for 5 minutes (corresponding to 2.77 mmol p-trifluoromethylaniline). The crude product was dissolved in ethyl acetate and washed with brine. The combined organic layers were dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (Biotage 25g Ultra-sil, eluent 3-15% ethyl acetate in hexane solution) to afford the target product 4-trifluoromethyl-N-methylaniline.

References

[1] Tetrahedron, 2018, vol. 74, # 25, p. 3124 - 3128

4-TRIFLUOROMETHYL-N-METHYLANILINE 97 Preparation Products And Raw materials

Raw materials

4-Aminobenzotrifluoride Trimethoxymethane Diethylamine Ethyl chloroformate Tetrahydrofuran Lithium Aluminum Hydride Hydrochloric acid Sulfuric acid 4-Dimethylaminopyridine

Preparation Products

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4-TRIFLUOROMETHYL-N-METHYLANILINE 97 Suppliers

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View Lastest Price from 4-TRIFLUOROMETHYL-N-METHYLANILINE 97 manufacturers

Zibo Shiji Zhonglian Medical Technology Co., Ltd.
Product
4-TRIFLUOROMETHYL-N-METHYLANILINE 22864-65-9
Price
US $1.00-1.00/KG
Min. Order
25KG
Purity
99.0%
Supply Ability
5000KG/th
Release date
2023-06-14
Shaanxi Dideu Medichem Co. Ltd
Product
N-Methyl-4-(trifluoromethyl)aniline 22864-65-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2019-12-31
Career Henan Chemical Co
Product
4-TRIFLUOROMETHYL-N-METHYLANILINE 97 22864-65-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KGS
Release date
2019-12-23

22864-65-9, 4-TRIFLUOROMETHYL-N-METHYLANILINE 97Related Search:

4-Bromo-2-fluoro-N-methylbenzamide N-methyl-2-bromo-4-fluorobenzamide 4-BroMo-3-fluoro-N-Methylaniline N-Methyl-2-fluoro-4-iodobenzamide 2-FLUORO-N-METHYL-4-NITROBENZAMIDE N-Methyl-4-nitroaniline 2-CHLORO-N-METHYLANILINE N,N-BIS(2-PHENYL-ETHYL)-N-METHYL-AMINE N-METHYL-N-PHENYLURETHANE N-METHYL-2-NITROANILINE N-METHYL-N-[4-(TRIFLUOROMETHYL)BENZYL]AMINE N-Methyl-4-Nitro-Benzamide 1-[4-(TRIFLUOROMETHYL)PHENYL]-2-THIOUREA 1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE N-ETHYL 2-NITRO-4-(TRIFLUOROMETHYL)ANILINE 1-METHYL-1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]HYDRAZINE 4-[4-(TRIFLUOROMETHYL)PHENYL]-3-THIOSEMICARBAZIDE 4-(TRIFLUOROMETHYL)ACETANILIDE

  • 4-(Methylamino)benzotrifluoride 98%
  • 4-(Methylamino)benzotrifluoride
  • BenzenaMine, N-Methyl-4-(trifluoroMethyl)-
  • 4-(Trifluoromethyl)-N-methylaniline 97%
  • 4-TRIFLUOROMETHYL-N-METHYLANILINE 97
  • 4-(TRIFLUOROMETHYL)-N-METHYLANILINE, 97% MIN.
  • n-methyl-n-[4-(trifluoromethyl)phenyl]amine
  • N-Methyl-4-(trifluoromethyl)
  • Fluoxetine impurity FXT-V
  • N-Methyl-p-trifluoromethylaniline
  • N-Methyl-4-(trifluoromethyl)-benzenamine
  • 4-(Trifluoromethyl)-<I>N<
  • Fluoxetine impurity FXT
  • 4-(Trifluoromethyl)-<i>N</i>-methylaniline
  • 22864-65-9
  • Phenyls & Phenyl-Het
  • C8
  • Nitrogen Compounds
  • Fluorine series
  • Building Blocks
  • Chemical Synthesis
  • Nitrogen Compounds
  • Organic Building Blocks
  • Amines
  • Phenyls & Phenyl-Het