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ChemicalBook > CAS DataBase List > 1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE

1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE

Uses
Product Name
1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE
CAS No.
30459-17-7
Chemical Name
1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE
Synonyms
RARECHEM AH CK 0204;4-PIPERAZINOBENZOTRIFLUORIDE;trifluoromethylphenylpiperazine;4-(1-Piperazinyl)benzotrifluoride;1-(4-Trifluoromethylphenyl)-pipera;1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE;N-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE;1-(4-Trifluormethylphenyl)-piperazine;1-(α,α,α-trifluoro-p-tolyl)piperazine;1-(4-Trifluoromethyphenyl) piperazine
CBNumber
CB2727370
Molecular Formula
C11H13F3N2
Formula Weight
230.23
MOL File
30459-17-7.mol
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1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE Property

Melting point:
88-92 °C
Boiling point:
309.1±42.0 °C(Predicted)
Density 
1.203
storage temp. 
RT, protect from light
solubility 
soluble in Methanol
pka
8.79±0.10(Predicted)
form 
Crystals
color 
Colorless to light yellow
BRN 
523408
InChIKey
IBQMAPSJLHRQPE-UHFFFAOYSA-N
CAS DataBase Reference
30459-17-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,C
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
10-34
Hazard Note 
Corrosive
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
80077
Product name
1-(4-Trifluoromethylphenyl)piperazine
Purity
≥98.0% (GC)
Packaging
1g
Price
$16.35
Updated
2025/07/31
Sigma-Aldrich
Product number
80077
Product name
1-(4-Trifluoromethylphenyl)piperazine
Purity
≥98.0% (GC)
Packaging
5G
Price
$36.5
Updated
2025/07/31
TCI Chemical
Product number
T2741
Product name
1-(4-Trifluoromethylphenyl)piperazine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$70
Updated
2025/07/31
TCI Chemical
Product number
T2741
Product name
1-(4-Trifluoromethylphenyl)piperazine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$257
Updated
2023/06/20
TRC
Product number
T797240
Product name
1-(4-Trifluoromethylphenyl)piperazine
Packaging
100mg
Price
$60
Updated
2021/12/16
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1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE Chemical Properties,Usage,Production

Uses

1-(4-Trifluoromethylphenyl)piperazine is a useful research chemical.

Chemical Properties

colorless to light yellow crystals

Synthesis

110-85-0

98-56-6

30459-17-7

Example 4: 4-Chlorobenzotrifluoride (18.5 g, 100 mmol) and piperazine (12.9 g, 150 mmol) were dissolved in 200 mL of tri-n-butylamine and degassed by passing nitrogen for 15 minutes at room temperature. Anhydrous sodium tert-butoxide (13.5 g, 140 mmol) was then added and degassing was continued for 10 min. In another vessel, [2-(2,6-dimethoxyphenyl)phenyl]dicyclohexylphosphine (41 mg, 0.1 mmol) was stirred with (dibenzylideneacetone)palladium (20 mg, 0.025 mmol) under nitrogen protection in 5 mL of degassed tetrahydrofuran for 30 min. Afterwards, the catalyst solution was added dropwise to the main reaction flask at room temperature via a transfer needle. After dropwise addition, the reaction system was heated to an internal temperature of 110 °C and the reaction was maintained for 8 hours. Upon completion of the reaction, it was cooled to 50 °C and filtered to remove the precipitated solids. The filtrate was concentrated under reduced pressure and extracted with dilute hydrochloric acid pH 3. After separation of the aqueous phase, it was adjusted to pH 10 with sodium hydroxide solution, precipitated as a white solid, filtered and dried under reduced pressure to give N-(4-trifluoromethylphenyl)piperazine 22.1 g (96 mmol, 96% yield). The purity of the product was determined by quantitative proton NMR and confirmed to be >99%.

References

[1] Patent: US2005/250791, 2005, A1. Location in patent: Page/Page column 4
[2] Patent: KR101589584, 2016, B1. Location in patent: Paragraph 0098-0102
[3] Patent: US2005/250791, 2005, A1. Location in patent: Page/Page column 4
[4] Patent: US2005/250791, 2005, A1. Location in patent: Page/Page column 4
[5] Patent: US2005/250791, 2005, A1. Location in patent: Page/Page column 4

1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE Suppliers

Belgium 1 China 95 France 1 Germany 6 India 4 Japan 1 Switzerland 1 United Kingdom 11 United States 18 Global 138
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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View Lastest Price from 1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE manufacturers

Dideu Industries Group Limited
Product
1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE 30459-17-7
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons
Release date
2022-02-23
Career Henan Chemical Co
Product
1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE 30459-17-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-09

30459-17-7, 1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINERelated Search:

1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE 1-(3-Trifluoromethylphenyl)piperazine hydrochloride 1-(4-CHLORO-3-TRIFLUOROMETHYLPHENYL)PIPERAZINE N-(3-Trifluoromethylphenyl)piperazine 1-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]PIPERAZINE N-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]PIPERAZINE 1-(2-TRIFLUOROMETHYLPHENYL)-PIPERAZINE PAPP, p-Aminophenethyl-m-trifluoromethylphenyl piperazine, 4-[2-[4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl]ethyl]benzeneamine 2-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE 95% 1-(4-Trifluoromethylphenyl)piperazine hydrochloride 1-(4-NITRO-3-TRIFLUOROMETHYLPHENYL)-PIPERAZINE,1-(4-NITRO-3-TRIFLUOROMETHYLPHENYL)-PIPERAZINE >98% 1-(4-NITRO-2-TRIFLUOROMETHYLPHENYL)-PIPERAZINE >98%,1-(4-NITRO-2-TRIFLUOROMETHYLPHENYL)-PIPERAZINE 1-(4-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]PIPERAZINO)-2-NITROVINYL METHYL SULFIDE N-(4-CHLOROPHENYL)-N'-[2-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)-5-(TRIFLUOROMETHYL)PHENYL]UREA 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-4-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]PIPERAZINE N-[2-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)-5-(TRIFLUOROMETHYL)PHENYL]-3-(TRIFLUOROMETHYL)BENZENECARBOXAMIDE 3-((4-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]PIPERAZINO)METHYLENE)-2-BENZOFURAN-1(3H)-ONE N-[2-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)-5-(TRIFLUOROMETHYL)PHENYL]-2-THIOPHENESULFONAMIDE

  • RARECHEM AH CK 0204
  • 4-(1-Piperazinyl)benzotrifluoride
  • 1-(4-Trifluoromethylphenyl)piperazine >=98.0% (GC)
  • N-(α, α, α-Trifluoro-p-tolyl)piperazine, 98%
  • N-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE
  • N-(ALPHA,ALPHA,ALPHA-TRIFLUORO-P-TOLYL)PIPERAZINE
  • 1-(ALPHA,ALPHA,ALPHA-TRIFLUORO-P-TOLYL)PIPERAZINE
  • 1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE
  • 1-(4-TRIFLUOROMETHYL-PHENYL)-PIPERAZINE DIHYDROCHLORIDE
  • 4-PIPERAZINOBENZOTRIFLUORIDE
  • trifluoromethylphenylpiperazine
  • 1-(4-Trifluormethylphenyl)-piperazine
  • 1-(α,α,α-trifluoro-p-tolyl)piperazine
  • 1-[4-(Trifluoromethyl)phenyl]piperazine 97%
  • 1-[4-(Trifluoromethyl)phenyl]piperazine97%
  • 1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE PURUM 98+% (GC)
  • 1-(4-TRIFLUOROMETHYLPHENYL)-PIPERAZINE >98%
  • 1-(4-Trifluoromethyphenyl) piperazine
  • N-(alpha,alpha,alpha-Trifluoro-p-tolyl)piperazine,98%
  • N-(alpha,alpha,alpha-Trifluoro-p-tolyl)piperazine, 98% 1GR
  • N-(alpha,alpha,alpha-Trifluoro-p-tolyl)piperazine, 98% 5GR
  • 1-[p-(Trifluoromethyl)phenyl]piperazine
  • Piperazine, 1-[4-(trifluoromethyl)phenyl]-
  • 1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE ISO 9001：2015 REACH
  • 1-(4-Trifluoromethylphenyl)-pipera
  • 30459-17-7
  • C11H13F3N3
  • Building Blocks
  • Piperazines
  • Heterocyclic Building Blocks
  • Building Blocks
  • C11
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • piperazines
  • pharmacetical
  • Piperidines, Piperidones, Piperazines