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LIMAPROST

Product Name
LIMAPROST
CAS No.
74397-12-9
Chemical Name
LIMAPROST
Synonyms
D02722;op1206;ono1206;IMAPROST;Limassol;LIMAPROST;n-1-oicacid;Limaprostst;Limaroprost;Limaprost RS
CBNumber
CB9226438
Molecular Formula
C22H36O5
Formula Weight
380.52
MOL File
74397-12-9.mol
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LIMAPROST Property

Melting point:
97-100°
Boiling point:
550.6±50.0 °C(Predicted)
Density 
1.118
storage temp. 
-20°C
solubility 
DMF: soluble
form 
crystalline
pka
4.78±0.10(Predicted)
color 
White to off-white
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
36/37/39-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
UK8362500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L6538
Product name
Limaprost
Purity
≥99%, crystalline
Packaging
1mg
Price
$165
Updated
2024/03/01
Cayman Chemical
Product number
13810
Product name
Limaprost
Purity
≥98%
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
13810
Product name
Limaprost
Purity
≥98%
Packaging
5mg
Price
$356
Updated
2024/03/01
Cayman Chemical
Product number
13810
Product name
Limaprost
Purity
≥98%
Packaging
10mg
Price
$593
Updated
2024/03/01
TRC
Product number
L461500
Product name
Limaprost
Packaging
5mg
Price
$275
Updated
2021/12/16
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LIMAPROST Chemical Properties,Usage,Production

Uses

Limaprost is an analog of Prostaglandin E1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is used as an antianginal.

Definition

ChEBI: Limaprost is a long-chain fatty acid.

Biochem/physiol Actions

Limaprost exhibits cytoprotective, vasodilatory, and antiplatelet activity. Limaprost has the potential to treat lumbar spinal canal stenosis (LSCS) and several ischaemic symptoms of thromboangiitis obliterans (TAO).

in vivo

Limaprost (OP1206) given orally at more than 100 μg/kg relieves Argipressin-induced ST depression of rat electrocardiogram (ECG)[1].
Intra-coronary injection of Limaprost (OP1206; 1-100 ng/kg) in dogs results in a remarkable increase of coronary blood flow without any influence on heart rate, blood pressure, myocardial oxygen consumption and redox potential[1].
Resistance in both large and small vessels of dog coronary artery is decreased by intravenous injection of Limaprost (OP1206; 1-3 mg/kg)[1].
Platelet aggregation, adhesiveness, bleeding time, and thrombocytopenia induced by ADP and collagen infusion in guinea-pigs are inhibited by oral administration of Limaprost (OP1206) at the same doses or doses less than those relieving Argipressin-induced ST depression of ECG[1].

LIMAPROST Preparation Products And Raw materials

Raw materials

Methanesulfonic acid Trifluoroacetic acid Methanesulfonyl chloride Isopropyl alcohol EC 3.1.1.1 4-Dimethylaminopyridine

Preparation Products

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LIMAPROST Suppliers

China 142 Europe 2 India 2 Switzerland 1 United Kingdom 4 United States 14 Global 165
Wuhan Wsem Biological Co., Ltd.
Tel
027-83778876 13667159345
Fax
027-83778876
Email
13667159345@163.com
Country
China
ProdList
1977
Advantage
55
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemvon Biotechnology Co., Ltd
Tel
021-50790412
Fax
+86-21-50790419
Email
info@chemvon.com
Country
China
ProdList
371
Advantage
57
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42957
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527621225; 15527768850
Email
1791901229@qq.com
Country
China
ProdList
7004
Advantage
52
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
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View Lastest Price from LIMAPROST manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
LIMAPROST 74397-12-9
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-06
Zhuozhou Wenxi import and Export Co., Ltd
Product
OP 1206; 17S,20-Dimethyl-trans-2,3-didehydro-PGE1 74397-12-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
OP 1206; 17S,20-Dimethyl-trans-2,3-didehydro-PGE1 74397-12-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

74397-12-9, LIMAPROSTRelated Search:

Ruxolitinib phosphate Linagliptin Limaprost-d3 LIMAPROST Limaprost a-cyclodextrin clathrate,limaprost alfadex

  • (2e,11-alpha,13e,15s,17s)-11,15-dihydroxy-17,20-dimethyl-9-oxoprost-2,13-die
  • ,13e,15s,17s)-
  • 11α,15s-dihydroxy-17s,20-dimethyl-9-oxo-prosta-2e,13e-dien-1-oic acid
  • 17S,20-Dimethyl-trans-D2-PGE1
  • 2-Heptenoic acid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]-5-oxocyclopentyl]-, (2E)- (9CI)
  • Prosta-2,13-dien-1-oic acid, 11,15-dihydroxy-17,20-dimethyl-9-oxo-, (2E,11a,13E,15S,17S)-
  • 17α,20-dimethyl-δ2-PGE1, 11α,15S-Dihydroxy-17S,20-dimethyl-9-oxo-prosta-2E,13E-dien-1-oic acid
  • (2E)-7-[(1R)-2β-[(1E,3S,5S)-3-Hydroxy-5-methyl-1-nonenyl]-3α-hydroxy-5-oxocyclopentan-1α-yl]-2-heptenoic acid
  • (2E,11R,13E,15S,17S)-11α,15-Dihydroxy-17,20-dimethyl-9-oxoprosta-2,13-dien-1-oic acid
  • (2E,11α,13E,15S,17S)-11,15-Dihydroxy-17,20-dimethyl-9-oxoprosta-2,13-dien-1-oic acid
  • D02722
  • (2E)-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonen-1-yl]-5-oxocyclopentyl]-2-heptenoic acid
  • 17S,20-DiMethyl-trans-Δ2-PGE1
  • Lima prostaglandin
  • 17α,20-dimethyl-δ2-PGE1
  • IMAPROST
  • (2E)-7-{(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methylnon-1-en-1-yl]-5-oxocyclopentyl}hept-2-enoic acid (non-preferred name)
  • 17s,20-dimethyl-trans-2,3-didehydro-pge1
  • 9-oxo-11-alpha,15-alpha-dihydroxy-17s,20-dimethylprosta-trans-2,trans-13-die
  • n-1-oicacid
  • ono1206
  • op1206
  • prost-2,13-dien-1-oicacid,11,15-dihydroxy-17,20-dimethyl-9-oxo-,(2e,11-alpha
  • 17ALPHA,20-DIMETHYL-DELTA2-PROSTAGLANDIN E1
  • 17A,20-DIMETHYL-D2-PGE1
  • 11A,15S-DIHYDROXY-17S,20-DIMETHYL-9-OXO-PROSTA-2E,13E-DIEN-1-OIC ACID
  • 11ALPHA, 15S-DIHYDROXY-17S,20-DIMETHYL-9-OXO-PROSTA-2E, 13E-DIEN-1-OIC ACID
  • LIMAPROST
  • Limaprost RS
  • 2-Heptenoic acid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonen-1-yl]-5-oxocyclopentyl]-, (2E)-
  • LIMAPROST USP/EP/BP
  • Limaprostst
  • (2E)-7-{(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methy...
  • LIMAPROST CAS
  • Limaroprost
  • (E)-7-((1R,2R,3R)-3-Hydroxy-2-((3S,5S,E)-3-hydroxy-5-methylnon-1-en-1-yl)-5-oxocyclopentyl)hept-2-enoic acid
  • Limassol
  • 17S-Methyl-w-homo-trans-D2-PGE1
  • 74397-12-9
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals