LIMAPROST

Product Name: LIMAPROST
CAS No.: 74397-12-9
Chemical Name: LIMAPROST
Synonyms: D02722;op1206;ono1206;IMAPROST;Limassol;LIMAPROST;n-1-oicacid;Limaprostst;Limaroprost;Limaprost RS
CBNumber: CB9226438
Molecular Formula: C22H36O5
Formula Weight: 380.52
MOL File: 74397-12-9.mol

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LIMAPROST Property

Melting point:: 97-100°
Boiling point:: 550.6±50.0 °C(Predicted)
Density: 1.118
storage temp.: -20°C
solubility: DMF: soluble
form: crystalline
pka: 4.78±0.10(Predicted)
color: White to off-white
InChIKey: OJZYRQPMEIEQFC-UAWLTFRCSA-N
SMILES: C(O)(=O)/C=C/CCCC[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)C[C@@H](C)CCCC

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 36/37/39-45
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: UK8362500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L6538
Product name: Limaprost
Purity: ≥99%, crystalline
Packaging: 1mg
Price: $170
Updated: 2025/07/31

Cayman Chemical

Product number: 13810
Product name: Limaprost
Purity: ≥98%
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 13810
Product name: Limaprost
Purity: ≥98%
Packaging: 5mg
Price: $356
Updated: 2024/03/01

Cayman Chemical

Product number: 13810
Product name: Limaprost
Purity: ≥98%
Packaging: 10mg
Price: $593
Updated: 2024/03/01

TRC

Product number: L461500
Product name: Limaprost
Packaging: 5mg
Price: $275
Updated: 2021/12/16

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LIMAPROST Chemical Properties,Usage,Production

Chemical Properties

White crystals, melting point 97-100℃.

Uses

Limaprost is an analog of Prostaglandin E1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is used as an antianginal.

Definition

ChEBI: Limaprost is a long-chain fatty acid.

Biochem/physiol Actions

Limaprost exhibits cytoprotective, vasodilatory, and antiplatelet activity. Limaprost has the potential to treat lumbar spinal canal stenosis (LSCS) and several ischaemic symptoms of thromboangiitis obliterans (TAO).

in vivo

Limaprost (OP1206) given orally at more than 100 μg/kg relieves Argipressin-induced ST depression of rat electrocardiogram (ECG)^[1].
Intra-coronary injection of Limaprost (OP1206; 1-100 ng/kg) in dogs results in a remarkable increase of coronary blood flow without any influence on heart rate, blood pressure, myocardial oxygen consumption and redox potential^[1].
Resistance in both large and small vessels of dog coronary artery is decreased by intravenous injection of Limaprost (OP1206; 1-3 mg/kg)^[1].
Platelet aggregation, adhesiveness, bleeding time, and thrombocytopenia induced by ADP and collagen infusion in guinea-pigs are inhibited by oral administration of Limaprost (OP1206) at the same doses or doses less than those relieving Argipressin-induced ST depression of ECG^[1].

LIMAPROST Preparation Products And Raw materials

Raw materials

Methanesulfonic acid Trifluoroacetic acid Methanesulfonyl chloride Isopropyl alcohol EC 3.1.1.1 4-Dimethylaminopyridine

Preparation Products

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LIMAPROST Suppliers

China 154 Europe 2 India 2 Switzerland 1 United Kingdom 4 United States 14 Global 177

SIGMA-RBI

Tel: --
Fax: --
Country: Switzerland
ProdList: 6896
Advantage: 91

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View Lastest Price from LIMAPROST manufacturers

Wuhan JiyunZen Tech Co., Ltd.

Product: Limaprost 74397-12-9
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-06-05

Shaanxi Dideu New Materials Co. Ltd

Product: LIMAPROST 74397-12-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-06

Zhuozhou Wenxi import and Export Co., Ltd

Product: OP 1206; 17S,20-Dimethyl-trans-2,3-didehydro-PGE1 74397-12-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

74397-12-9, LIMAPROSTRelated Search:

Ruxolitinib phosphate Linagliptin Limaprost-d3 LIMAPROST Limaprost a-cyclodextrin clathrate,limaprost alfadex

(2e,11-alpha,13e,15s,17s)-11,15-dihydroxy-17,20-dimethyl-9-oxoprost-2,13-die

,13e,15s,17s)-

11α,15s-dihydroxy-17s,20-dimethyl-9-oxo-prosta-2e,13e-dien-1-oic acid

17S,20-Dimethyl-trans-D2-PGE1

2-Heptenoic acid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]-5-oxocyclopentyl]-, (2E)- (9CI)

Prosta-2,13-dien-1-oic acid, 11,15-dihydroxy-17,20-dimethyl-9-oxo-, (2E,11a,13E,15S,17S)-

17α,20-dimethyl-δ2-PGE1, 11α,15S-Dihydroxy-17S,20-dimethyl-9-oxo-prosta-2E,13E-dien-1-oic acid

(2E)-7-[(1R)-2β-[(1E,3S,5S)-3-Hydroxy-5-methyl-1-nonenyl]-3α-hydroxy-5-oxocyclopentan-1α-yl]-2-heptenoic acid

(2E,11R,13E,15S,17S)-11α,15-Dihydroxy-17,20-dimethyl-9-oxoprosta-2,13-dien-1-oic acid

(2E,11α,13E,15S,17S)-11,15-Dihydroxy-17,20-dimethyl-9-oxoprosta-2,13-dien-1-oic acid

D02722

(2E)-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonen-1-yl]-5-oxocyclopentyl]-2-heptenoic acid

17S,20-DiMethyl-trans-Δ2-PGE1

Lima prostaglandin

17α,20-dimethyl-δ2-PGE1

IMAPROST

(2E)-7-{(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methylnon-1-en-1-yl]-5-oxocyclopentyl}hept-2-enoic acid (non-preferred name)

17s,20-dimethyl-trans-2,3-didehydro-pge1

9-oxo-11-alpha,15-alpha-dihydroxy-17s,20-dimethylprosta-trans-2,trans-13-die

n-1-oicacid

ono1206

op1206

prost-2,13-dien-1-oicacid,11,15-dihydroxy-17,20-dimethyl-9-oxo-,(2e,11-alpha

17ALPHA,20-DIMETHYL-DELTA2-PROSTAGLANDIN E1

17A,20-DIMETHYL-D2-PGE1

11A,15S-DIHYDROXY-17S,20-DIMETHYL-9-OXO-PROSTA-2E,13E-DIEN-1-OIC ACID

11ALPHA, 15S-DIHYDROXY-17S,20-DIMETHYL-9-OXO-PROSTA-2E, 13E-DIEN-1-OIC ACID

LIMAPROST

Limaprost RS

2-Heptenoic acid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonen-1-yl]-5-oxocyclopentyl]-, (2E)-

LIMAPROST USP/EP/BP

Limaprostst

(2E)-7-{(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methy...

LIMAPROST CAS

Limaroprost

(E)-7-((1R,2R,3R)-3-Hydroxy-2-((3S,5S,E)-3-hydroxy-5-methylnon-1-en-1-yl)-5-oxocyclopentyl)hept-2-enoic acid

Limassol

17S-Methyl-w-homo-trans-D2-PGE1

74397-12-9

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Intermediates & Fine Chemicals

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