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N4-Benzoylcytosine

Product Name
N4-Benzoylcytosine
CAS No.
26661-13-2
Chemical Name
N4-Benzoylcytosine
Synonyms
N3333-FSI;N-Benzoylcytosine;4-BENZOYLCYTOSINE;N4-BENZOYLCYTOSINE;Atrazine Impurity 7;LABOTEST-BB LT00138031;N4-Benzoylcytosine 98%;N4-Benzoylcytosine >Sofosbuvir Impurity 141;N4-Benzoylcytosine USP/EP/BP
CBNumber
CB4118859
Molecular Formula
C11H9N3O2
Formula Weight
215.21
MOL File
26661-13-2.mol
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N4-Benzoylcytosine Property

Melting point:
>300 °C (dec.) (lit.)
Density 
1.33±0.1 g/cm3(Predicted)
vapor pressure 
0Pa at 25℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Aqueous Acid (Slightly, Heated), DMSO+DCl (Slightly, Heated)
form 
Solid
pka
7.75±0.10(Predicted)
color 
Off-White
InChI
InChI=1S/C11H9N3O2/c15-10(8-4-2-1-3-5-8)13-9-6-7-12-11(16)14-9/h1-7H,(H2,12,13,14,15,16)
InChIKey
XBDUZBHKKUFFRH-UHFFFAOYSA-N
SMILES
C(NC1=CC=NC(=O)N1)(=O)C1=CC=CC=C1
Surface tension
72.2mN/m at 1g/L and 21.2℃
CAS DataBase Reference
26661-13-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
20/22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
436798
Product name
N4-Benzoylcytosine
Purity
98%
Packaging
10g
Price
$48.2
Updated
2025/07/31
TCI Chemical
Product number
B3169
Product name
N4-Benzoylcytosine
Purity
>97.0%(HPLC)(T)
Packaging
5g
Price
$18
Updated
2025/07/31
TRC
Product number
B207905
Product name
N4-Benzoylcytosine
Packaging
100g
Price
$150
Updated
2021/12/16
Usbiological
Product number
261642
Product name
N4-Benzoylcytosine
Packaging
100g
Price
$333
Updated
2021/12/16
Matrix Scientific
Product number
102032
Product name
N4-Benzoylcytosine
Purity
>95%
Packaging
100g
Price
$78
Updated
2021/12/16
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N4-Benzoylcytosine Chemical Properties,Usage,Production

Chemical Properties

White or almost white crystalline powder

Uses

N4-Benzoylcytosine may be employed for the following syntheses:

  • 3′-C-ethynyl and 3′-C-(1,4-disubstituted-1,2,3-triazolo) double-headed pyranonucleosides
  • 2′-C-methyl-4′-thiocytidine, via the Pummerer reaction
  • 2′-fluorinated L-nucleoside analogs

Uses

N4-Benzoylcytosine is a reactant in the synthesis of 1'',2''-cyclopentyl nucleosides as potential antiviral agents.

General Description

N4-Benzoylcytosine is an amide and its anti-microbial activity against pathogenic microorganisms has been studied using the Disk Diffusion and the Pour Plate method. It can be synthesized via the condensation of benzoyl chloride with cytosine.

Synthesis

71-30-7

98-88-4

26661-13-2

Under nitrogen protection, 100 L of acetonitrile was added to the reactor as a solvent, followed by 22 kg (196 mol) of 6-aminopyrimidin-2(1H)-one (anhydrous cytosine), 25 g of 4-dimethylaminopyridine (DMAP), and 24 kg of triethylamine as a base. After cooling the reaction mixture to 5-8°C, 34 kg of benzoyl chloride was slowly added dropwise. After the dropwise addition, the reaction mixture was allowed to warm up naturally to room temperature and stirred at 25°C for 1 hour. Subsequently, the reaction mixture was slowly heated to 40-45°C and kept at this temperature for 2 hours. Upon completion of the reaction, it was cooled to room temperature and press-filtered. About 60 L of acetonitrile filtrate was collected for recycling, and the filter cake was washed sequentially with water and ethanol, and dried to give 40 kg of a white solid product, N4-benzoylcytosine, which was analyzed by liquid chromatography to be 99.2% pure.

References

[1] Patent: US2011/245458, 2011, A1
[2] Chemical Communications, 2017, vol. 53, # 64, p. 8952 - 8955
[3] Heterocyclic Communications, 2007, vol. 13, # 4, p. 251 - 256
[4] Russian Journal of Organic Chemistry, 2008, vol. 44, # 3, p. 358 - 361
[5] Journal of the Chemical Society, 1956, p. 2388,2392

N4-Benzoylcytosine Preparation Products And Raw materials

Raw materials

Benzoic anhydride Acetonitrile Sodium Urea Malonaldehyde bis(diethyl acetal) Hydroxylamine hydrochloride 1-Butanol Diethyl sulfate Sulfuric acid 4-Dimethylaminopyridine

Preparation Products

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N4-Benzoylcytosine Suppliers

Americas 1 Canada 1 China 377 Europe 1 France 1 Germany 5 India 18 Japan 1 Slovakia 1 Switzerland 2 The Netherlands 1 United Kingdom 13 United States 36 Global 458
Suzhou Carbonwell Pharma-Tech Co., Ltd
Tel
0512-0512-88981216 13776013740
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1320558046@qq.com
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China
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Shangqiu Huakang Zhongbang Biotechnology Co., Ltd
Tel
13011705167
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3838015797@qq.com
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China
ProdList
154
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Zhongshan Dixin Chemical Co., Ltd
Tel
19849939632
Email
2470479589@qq.com
Country
China
ProdList
1748
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58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
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jkinfo@jkchemical.com
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China
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96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006356688 18621169109
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86-21-61259102
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market03@meryer.com
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China
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40228
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INTATRADE GmbH
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+49 3493/605464
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+49 3493/605470
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sales@intatrade.de
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Germany
ProdList
3572
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
Fax
021-67121385
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Sales-CN@TCIchemicals.com
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China
ProdList
24529
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ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
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China
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2572
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Ark Pharm, Inc.
Tel
847-367-3680
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847-367-3681
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sales@arkpharminc.com
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United States
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Energy Chemical
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021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
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China
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View Lastest Price from N4-Benzoylcytosine manufacturers

Xinxiang Aurora Biotechnology Co.,Ltd.
Product
N4-Benzoylcytosine 26661-13-2
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20Ton
Release date
2024-11-01
WUHAN FORTUNA CHEMICAL CO., LTD
Product
N4-Benzoylcytosine 26661-13-2
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
99%min HPLC
Supply Ability
100kg
Release date
2021-08-06
Hebei Chuanghai Biotechnology Co., Ltd
Product
N4-Benzoylcytosine 26661-13-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-27

26661-13-2, N4-BenzoylcytosineRelated Search:

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