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Diethyl sulfate

Product Name
Diethyl sulfate
CAS No.
64-67-5
Chemical Name
Diethyl sulfate
Synonyms
DIETHYL SULPHATE;DS;ETHYL SULFATE;SULFURIC ACID DIETHYL ESTER;DHYS;Ethylsulpate;Diethylsulfat;Diaethylsulfat;DIETHYL SULFATE;Two ethyl sulfate
CBNumber
CB9483493
Molecular Formula
C4H10O4S
Formula Weight
154.18
MOL File
64-67-5.mol
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Diethyl sulfate Property

Melting point:
-24 °C (lit.)
Boiling point:
208 °C (lit.)
Density 
1.177 g/mL at 25 °C (lit.)
vapor density 
5.3 (vs air)
vapor pressure 
<0.01 mm Hg ( 20 °C)
refractive index 
n20/D 1.399(lit.)
Flash point:
173 °F
storage temp. 
Refrigerator (+4°C)
solubility 
soluble in Ether,Alcohol
form 
Liquid
color 
Clear
Odor
char. faint ether odor, irritating after-effect
Water Solubility 
5 g/L (20 ºC)
Merck 
14,3130
BRN 
1209714
Dielectric constant
29.0(20℃)
Stability:
Moisture sensitive. May react violently with oxidizing agents.
CAS DataBase Reference
64-67-5(CAS DataBase Reference)
IARC
2A (Vol. 54, 71) 1999
NIST Chemistry Reference
Sulfuric acid, diethyl ester(64-67-5)
EPA Substance Registry System
Diethyl sulfate (64-67-5)
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Safety

Hazard Codes 
T
Risk Statements 
45-46-20/21/22-34
Safety Statements 
53-45
RIDADR 
UN 1594 6.1/PG 2
WGK Germany 
3
RTECS 
WS7875000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29209090
Hazardous Substances Data
64-67-5(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 0.88 g/kg (Smyth)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H340May cause genetic defects

H350May cause cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D100706
Product name
Diethyl sulfate
Purity
98%
Packaging
2kg
Price
$99.6
Updated
2024/03/01
Sigma-Aldrich
Product number
D100706
Product name
Diethyl sulfate
Purity
98%
Packaging
1kg
Price
$106
Updated
2024/03/01
TCI Chemical
Product number
D0525
Product name
Diethyl Sulfate
Purity
>98.0%(GC)
Packaging
25mL
Price
$19
Updated
2024/03/01
TCI Chemical
Product number
D0525
Product name
Diethyl Sulfate
Purity
>98.0%(GC)
Packaging
500mL
Price
$30
Updated
2024/03/01
Alfa Aesar
Product number
L14291
Product name
Diethyl sulfate, 98%
Packaging
100ml
Price
$25.65
Updated
2024/03/01
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Diethyl sulfate Chemical Properties,Usage,Production

Description

Diethyl sulfate is a colorless, oily liquid witha faint peppermint-like or ether-like odor. Turns brownon contact with air. Molecular weight=154.20; Boilingpoint=209℃ (decomposes); Freezing/Melting point=225℃; Flash point=104℃; Autoignitiontemperature=436℃. Hazard Identification (based onNFPA-704 M Rating System): Health 3, Flammability 1,Reactivity 1. Insoluble in water; slight decomposition.

Chemical Properties

Diethyl sulfate is a colorless, oily liquid with a faint peppermint- like odor, which darkens with age (Budavari, 1996). It is miscible with alcohol and ether (O'Neil, 2006). At higher temperatures, DES rapidly decomposes into monoethyl sulfate and alcohol (NTP, 2011).

Uses

The primary use of diethyl sulfate is as a chemical intermediate (ethylating agent) in synthesis of ethyl derivatives of phenols, amines, and thiols; as an accelerator in the sulfation of ethylene; and in some sulfonation processes. It is used to manufacture dyes, pigments, carbonless paper, and textiles. It is an intermediate in the indirect hydration (strong acid) process for the preparation of synthetic ethanol from ethylene. Smaller quantities are used in household products, cosmetics, agricultural chemicals, pharmaceuticals, and laboratory reagents (IARC 1992, 1999, HSDB 2009). In 1966, it was used as a mutagen to create the Luther variety of barley (IARC 1974).

Application

Diethyl sulfate can be used as a reactant for the synthesis of:
Biologically active compounds such as bispyrazole, pyrazolopyrimidine and pyridine containing antipyrinyl moieties.
N-substituted-2-styryl-4(3H)-quinazolinones.
Ionic liquids with pyrrolidinium, piperidinium and morpholinium cations, having potential applications as electrolytes.
It can also be used as an alkylating agent to synthesize 1-alkyl/aralkyl-2-(1-arylsufonylalkyl)benzimidazoles and an ionic liquid ethylmethylimidazole ethylsulfate ([EMIM][EtSO4].

Definition

ChEBI: Diethyl sulfate is the diethyl ester of sulfuric acid. It has a role as a carcinogenic agent, an apoptosis inducer, an alkylating agent and a mutagen.

Preparation

Diethyl sulfate is produced from ethanol and sulfuric acid, from ethylene and sulfuric acid, or from diethyl ether and fuming sulfuric acid (Budavari, 1996).

General Description

Diethyl sulfate appears as a clear colorless liquid with a peppermint odor. Burns, though may be difficult to ignite. Corrosive to metals and tissue. It is a potent alkylating agent.

Air & Water Reactions

Highly flammable. Slowly reacts with water to form ethyl alcohol, a flammable liquid, and ethyl sulfate, with eventual conversion to sulfuric acid.

Reactivity Profile

The presence of moisture in a metal container of Diethyl sulfate caused the formation of sulfuric acid which reacts with the metal to release hydrogen which pressurized and exploded the container [Chem. Abst. 28:2908(1934)].

Health Hazard

May be fatal if inhaled, swallowed or absorbed through skin. Inhalation causes nausea and vomiting. Causes burns to skin and eyes. Ingestion may cause nausea, vomiting abdominal pain and collapse.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by inhalation and subcutaneous routes. Moderately toxic by ingestion and sktn contact. A severe skin irritant. An experimental teratogen. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidzing materials. Moisture causes liberation of H2SO4. Violent reaction with potassium tert-butoxide. Reacts violently with 3,8-dnitro-6-phenylphenanthridine + water. Reaction with iron + water forms explosive hydrogen gas. To fight fire, use alcohol foam, H2O foam, CO2, dry chemicals. When heated to decomposition it emits toxic fumes of SOx. See also SULFATES.

Potential Exposure

Tumorigen,Mutagen; Reproductive Effector; Primary Irritant. Used asan industrial chemical; ethylating agent (synthesis of dyeand pharmaceuticals); synthesizing agent of ammoniumchloride compounds; in making isopropyl alcohol, ethylalcohol, and other chemicals; dehydrating agent; extractantfor gasoline.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Gastric lavage (stomach wash), if swallowed,followed by saline catharsis. Do not make an unconsciousperson vomit. Medical observation is recommended for24-48 h after breathing overexposure, as pulmonary edemamay be delayed. As first aid for pulmonary edema, a doctoror authorized paramedic may consider administering a corticosteroid spray.

Carcinogenicity

Diethyl sulfate is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.

storage

(1) Color Code—Yellow Stripe (strong reducingagent): Reactivity Hazard; Store separately in an area isolated from flammables, combustibles, or other yellow-codedmaterials. (2) Color Code—Blue: Health Hazard/Poison:Store in a secure poison location. Protect against physicaldamage. Store in a cool, dry, well-ventilated location awayfrom any area where the fire hazard may be acute. Outsideor detached storage is preferred. Separate from other storage. Before entering confined space where DS may be present, check to make sure that an explosive concentrationdoes not exist. Store in tightly closed containers in a cool,well-ventilated area. Metal containers involving the transferof this chemical should be grounded and bonded. Wherepossible, automatically pump liquid from drums or otherstorage containers to process containers. Drums must be equipped with self-closing valves, pressure vacuum bungs,and flame arresters. Use only nonsparking tools and equipment, especially when opening and closing containers ofthis chemical. Sources of ignition, such as smoking andopen flames, are prohibited where this chemical is used,handled, or stored in a manner that could create a potentialfire or explosion hazard. Wherever this chemical is used,handled, manufactured, or stored, use explosion-proof electrical equipment and fittings. A regulated, marked areashould be established where this chemical is handled, used,or stored in compliance with OSHA Standard 1910.1045.

Shipping

This compound requires a shipping label of“POISONOUS/TOXIC MATERIALS.” It falls in HazardClass 6.1 and Packing Group II.

Purification Methods

Wash the ester with aqueous 3% Na2CO3 (to remove acidic material), then distilled water, dry (CaCl2), filter and distil it in a vacuum. It is an ethylating agent and blisters the skin. [Beilstein 1 IV 1236.]

Incompatibilities

Vigorous reaction with strong oxidizersor water (forms sulfuric acid). The aqueous solution is astrong acid; incompatible with nonoxidizing mineral acids,organic acids, bases, acrylates, aldehydes, alcohols, alkylene oxides, ammonia, aliphatic amines, alkanolamines, aromatic amines, amides, chlorates, epichlorohydrin,fulminates, glycols, isocyanates, ketones, powdered metals,organic anhydrides, perchlorates, picrates, substituted allyls,phenols, and cresols. DS decomposes when heated, producing diethyl ether and fumes of sulfur oxides. DS is a strongreducing agent; reacts with oxidizing materials. Formsexplosive hydrogen gas on contact with iron in the presenceof water.

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Diethyl sulfate Suppliers

Shandong Liteng Biotechnology Co., Ltd
Tel
18663721413
Email
18663721413@163.com
Country
China
ProdList
45
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Dalian Idery Biotechnology Co., Ltd.
Tel
0411-62696576 15141125520
Fax
0411-66160116
Email
dlidery@yeah.net
Country
China
ProdList
144
Advantage
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Jinan Century Tongda Chemical Co., Ltd.
Tel
13370556116
Fax
0531-85917596
Email
3350933950@qq.com
Country
China
ProdList
353
Advantage
58
Jinan Century Tongda Chemical Co., Ltd.
Tel
15605418165
Email
781463312@qq.com
Country
China
ProdList
378
Advantage
58
Qiyuan (Guangdong) Pharmaceutical Chemical Co., Ltd.
Tel
400-666-9280 18026564465
Email
304903156@qq.com
Country
China
ProdList
8011
Advantage
58
shandongyukanghuagongyouxiangongsi
Tel
0531-053187106227 15588839549
Fax
053187106227
Email
chifenghansen11@163.com
Country
China
ProdList
183
Advantage
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Shandong Yukang Chemical Co., Ltd
Tel
15562663522 15562663522
Email
sdykhg1@163.com
Country
China
ProdList
183
Advantage
58
shandongxinheng
Tel
15269161022
Email
15269161022@163.com
Country
China
ProdList
164
Advantage
58
shandongxinhenghuagongyouxiangongsi
Tel
1526-9160602 15269160602
Email
15269160602@163.com
Country
China
ProdList
185
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
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View Lastest Price from Diethyl sulfate manufacturers

Hebei Duling International Trade Co. LTD
Product
Diethyl sulfate 64-67-5
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
300MT/month
Release date
2022-11-26
Hebei Mojin Biotechnology Co., Ltd
Product
Diethyl sulfate 64-67-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-25
Hebei Guanlang Biotechnology Co,.LTD
Product
Diethyl sulfate 64-67-5
Price
US $10.70/Kg/Drum
Min. Order
10g
Purity
99%
Supply Ability
10000kg
Release date
2021-07-30

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