(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one

Product Name: (3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one
CAS No.: 879551-04-9
Chemical Name: (3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one
Synonyms: -3-methyldihydrofuran-2(3H);-3-Fluoro-4-hydroxy-5-(hydroxymethyl);D-erythro-Pentonic acid, 2-deoxy-2-fluoro-2-methyl-, |-lactone;(3R,4R,5R)-3-FLUORO-4-HYDROXY-5-(HYDROXYMETHYL)-3-METHYL-DIHYD;(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihy...;D-erythro-Pentonic acid, 2-deoxy-2-fluoro-2-methyl-, gamma-lactone;(3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyloxolan-2-one;(2R)-2-Deoxy-2-fluoro-2-methyl-D-erythro-pentonic acid gamma-lactone;D-erythro-Pentonic acid, 2-deoxy-2-fluoro-2-methyl-, γ-lactone, (2R)-;(3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-
CBNumber: CB92654176
Molecular Formula: C6H9FO4
Formula Weight: 164.13
MOL File: 879551-04-9.mol

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(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one Property

Melting point:: 142-143℃ (ethyl acetate heptane )
Boiling point:: 352.7±42.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 11.46±0.60(Predicted)
Appearance: Off-white to light brown Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F592010
Product name: (3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one
Packaging: 1g
Price: $80
Updated: 2021/12/16

TRC

Product number: F592010
Product name: (3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one
Packaging: 5g
Price: $330
Updated: 2021/12/16

Biosynth Carbosynth

Product number: MF44944
Product name: (3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-one
Packaging: 2g
Price: $220
Updated: 2021/12/16

Matrix Scientific

Product number: 112541
Product name: D-erythro-Pentonic acid
Purity: 2-deoxy-2-fluoro-2-methyl-gamma-lactone
Packaging: 5g
Price: $365
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H29-3-05
Product name: (3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-one
Packaging: 25g
Price: $400
Updated: 2021/12/16

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(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one Chemical Properties,Usage,Production

Uses

(3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one can be used for synthetic preparation for asymmetric synthesis of dibenzoyl fluoro methyl-D-ribono-γ-lactone via asymmetric aldol condensation and enzymic hydrolysis from isopropylidene-D-glyceraldehyde and Et fluoropropionate.

Synthesis

Chlorination or acylation of trans-5-hydroxy-1,3-oxathiolane-2-carboxylic acid-L menthol ester and coupling with cytosine and 5-fluorocytosine or with silicone-protected cytosine and 5-fluorocytosine. -The process of chlorination or acylation requires high requirements for the maintenance of the chiral structure, prolongs the process flow, increases the process cost, and reduces the yield of the final product.

(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one Suppliers

China 81 India 5 United Kingdom 1 United States 8 Global 95

Energy Chemical

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Shanghai Hanhong Scientific Co.,Ltd.

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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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Bide Pharmatech Ltd.

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Shanghai YuLue Chemical Co., Ltd.

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Shenzhen Nexconn Pharmatechs Ltd.

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Credit Asia Chemical Co., Ltd.

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Intelligence Pharm Science(Shanghai) Co., Ltd.

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Nanjing Chempioneer Pharmaceutical Co., Ltd.

Tel: 18068075658
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View Lastest Price from (3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one manufacturers

Career Henan Chemical Co

Product: (3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one 879551-04-9
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-13

879551-04-9, (3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-oneRelated Search:

Sofosbuvir L-Alanine, N-[(R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester L-Alanine isopropyl ester hydrochloride (2'R)-2'-Deoxy-2'-fluoro-2'-Methyl-uridine 3',5'-dibenzoate 2'-deoxy-2'-fluoro-2'-C-methyluridine PSI-6130 derivative ((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate 4-Pyridinecarboxamide, 3-chloro-N-methyl- 3-Pyridinecarboxamide, 4-chloro-N-methyl- ((2R,3S,4S)-3-(benzoyloxy)-4-fluoro-4-Methyl-5-oxotetrahydrofuran-2-yl)Methyl benzoate N4-Benzoylcytosine (2R)-2-Deoxy-2-fluoro-2-Methyl-D-erythro-pentonic acid-g-lactone 3,5-bis(4-chlorobenzoate) 2'-C-Methyl-, 2',3',5'-tribenzoateuridine 2'-deoxy-2'-fluoro-2'-C-methylcytidine 3-Pyridinecarboxamide, 5-chloro-N-methyl- 1-(5-Bromo-4-methylthiophen-2-yl)ethanone Pyrimidine nucleoside antibiotic

(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one

(3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyloxolan-2-one

(3R,4R,5R)-3-FLUORO-4-HYDROXY-5-(HYDROXYMETHYL)-3-METHYL-DIHYD

(2R)-2-Deoxy-2-fluoro-2-methyl-D-erythro-pentonic acid gamma-lactone

(3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-2-one

D-erythro-Pentonic acid, 2-deoxy-2-fluoro-2-methyl-, |-lactone

D-erythro-Pentonic acid, 2-deoxy-2-fluoro-2-methyl-, gamma-lactone

-3-Fluoro-4-hydroxy-5-(hydroxymethyl)

-3-methyldihydrofuran-2(3H)

D-erythro-Pentonic acid, 2-deoxy-2-fluoro-2-methyl-, γ-lactone, (2R)-

(4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one

(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one USP/EP/BP

(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihy...

(3R,4R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one

(3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-

(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-one - [F10634]

(3R,4R,5R)-3-fluoro-4-hydroxy (hydroxymethyl)-3 methyldihydrofuran-2(3H)-one

(3R,4R,5R)-3-fluoro-4-hydroxy -5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one Sofosbuvir intermediate

879551-04-9

Sofosbuvir intermediate