L-Alanine isopropyl ester hydrochloride
- Product Name
- L-Alanine isopropyl ester hydrochloride
- CAS No.
- 62062-65-1
- Chemical Name
- L-Alanine isopropyl ester hydrochloride
- Synonyms
- L-Alanine isopropyl ester HCl;Ala-OiPr.HCl;L-Ala.oipr.Hcl;anine isopropyL;Tenofovir Impurity 78;Tenofovir Impurity 14 HCl;L-Amlamine Isopropyl ester;Alanine isopropyl hydrochloride;propan-2-yl (2S)-2-aminopropanoate;L- alanine isopropyl hydrochloride
- CBNumber
- CB82547022
- Molecular Formula
- C6H14ClNO2
- Formula Weight
- 167.63
- MOL File
- 62062-65-1.mol
L-Alanine isopropyl ester hydrochloride Property
- Melting point:
- 85 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Water Solubility
- Soluble in water
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- powder to crystal
- color
- White to Orange to Green
- optical activity
- Consistent with structure
- Stability:
- Very Hygroscopic
- InChI
- InChI=1/C6H13NO2.ClH/c1-4(2)9-6(8)5(3)7;/h4-5H,7H2,1-3H3;1H/t5-;/s3
- InChIKey
- YAQKNCSWDMGPOY-JEDNCBNOSA-N
- SMILES
- C(=O)([C@@H](N)C)OC(C)C.Cl |&1:2,r|
Safety
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H371May cause damage to organs
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P309+P311IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A2588
- Product name
- L-Alanine Isopropyl Ester Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- A2588
- Product name
- L-Alanine Isopropyl Ester Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $97
- Updated
- 2025/07/31
- Product number
- I822220
- Product name
- (S)-Isopropyl-2-aminopropanoateHydrochloride
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- JK1413915
- Product name
- L-AlanineisopropylesterHCl
- Purity
- 98%
- Packaging
- 5g
- Price
- $56
- Updated
- 2021/12/16
- Product number
- FA30147
- Product name
- L-Alanine isopropyl ester HCl
- Packaging
- 250g
- Price
- $65
- Updated
- 2021/12/16
L-Alanine isopropyl ester hydrochloride Chemical Properties,Usage,Production
Uses
L-Alanine isopropyl ester hydrochloride is a reagent used in the synthesis of anti- hepatitis C virus prodrugs based on imidazotriazine and pyrrolotriazine molecules. Further, it reacts with (1R:2R)-2-Hydroxy-πnanone-3 to prepare isopropyl (1R,2R,5R)-2′-[(2-hydroxypinan-3-ylene)amino]propanoate.
Uses
(S)-Isopropyl-2-aminopropanoate Hydrochloride, is a chemical reagent used in the synthesis of anti-HCV prodrugs based on imidazotriazine and pyrrolotriazine molecules.
Synthesis
56-41-7
67-63-0
39613-92-8
To a reaction flask equipped with a mechanical stirrer, reflux condenser tube, thermometer and under nitrogen protection was added L-alanine (5.0 g, 56.1 mmol) and 11.1% w/w isopropanol HCl solution (73.8 g, 224.5 mmol). The reaction mixture was heated to reflux temperature (80-85 °C) and kept for 4 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) using a 7:3 ethanol-water mixture as eluent and ninhydrin as color developer. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove isopropanol and isopropyl acetate, and the residual solvent was removed by multiple azeotropic distillations to give the final product (R)-isopropyl (R)-2-aminopropionate hydrochloride in oil form (9.4 g, quantitative yield).
References
[1] Patent: WO2016/151542, 2016, A1. Location in patent: Page/Page column 19
[2] European Journal of Organic Chemistry, 2018, vol. 2018, # 20, p. 2622 - 2628
[3] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 12, p. 1197 - 1201
[4] Patent: WO2015/38596, 2015, A1. Location in patent: Page/Page column 237; 238
[5] Patent: WO2016/145142, 2016, A1. Location in patent: Page/Page column 287
L-Alanine isopropyl ester hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from L-Alanine isopropyl ester hydrochloride manufacturers
- Product
- L-Alanine isopropyl ester hydrochloride 62062-65-1
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 500kgs
- Release date
- 2021-08-27
- Product
- L-ALa-Oipr. HCL 62062-65-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-03-22
- Product
- L-Alanine isopropyl ester hydrochloride 62062-65-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-27