L-Phenylalanine benzyl ester hydrochloride
- Product Name
- L-Phenylalanine benzyl ester hydrochloride
- CAS No.
- 2462-32-0
- Chemical Name
- L-Phenylalanine benzyl ester hydrochloride
- Synonyms
- L-Phenylalanine Benzyl Ester HCl;Nsc522226;PHE-OBZL HCL;anine BenzyL;H-PHE-OBZL HCL;H-PHE-OBZL.HCI;H-PHE-OBZL·HCL;H-L-Phe-OBzl*HCl;PHENYLALANINE-OBZL HCL;H-Phe-OBzl hydrochloride
- CBNumber
- CB0330248
- Molecular Formula
- C16H18ClNO2
- Formula Weight
- 291.77
- MOL File
- 2462-32-0.mol
L-Phenylalanine benzyl ester hydrochloride Property
- Melting point:
- 197-200 °C
- alpha
- -13 º (c=1% in 80% acetic acid)
- refractive index
- -12 ° (C=1, 80% acetic acid)
- storage temp.
- Inert atmosphere,Room Temperature
- Water Solubility
- Soluble in water
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Crystalline Powder
- color
- White to off-white
- optical activity
- [α]20/D 13±1°, c = 1% in acetic acid: water (4:1)
- BRN
- 3919200
- InChI
- InChI=1/C16H17NO2.ClH/c17-15(11-13-7-3-1-4-8-13)16(18)19-12-14-9-5-2-6-10-14;/h1-10,15H,11-12,17H2;1H/t15-;/s3
- InChIKey
- CEXFHIYDTRNBJD-AVAJOTNLNA-N
- SMILES
- C1(=CC=CC=C1)C[C@H](N)C(=O)OCC1C=CC=CC=1.Cl |&1:7,r|
- CAS DataBase Reference
- 2462-32-0(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 29224999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 78060
- Product name
- L-Phenylalanine benzyl ester hydrochloride
- Purity
- ≥99.0% (AT)
- Packaging
- 5g
- Price
- $68.67
- Updated
- 2025/07/31
- Product number
- P1718
- Product name
- L-Phenylalanine Benzyl Ester Hydrochloride
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 5g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- P1718
- Product name
- L-Phenylalanine Benzyl Ester Hydrochloride
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 25g
- Price
- $125
- Updated
- 2025/07/31
- Product number
- 239373
- Product name
- L-Phenylalanine benzyl ester hydrochloride
- Packaging
- 5g
- Price
- $170
- Updated
- 2021/12/16
- Product number
- P319445
- Product name
- L-Phenylalanine Benzyl Ester Hydrochloride
- Packaging
- 5g
- Price
- $70
- Updated
- 2021/12/16
L-Phenylalanine benzyl ester hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White crystal
Uses
L-Phenylalanine Benzyl Ester Hydrochloride is a commonly used reactant for the synthesis of L-isoserine derivatives as aminopeptidase N inhibitors and PF-04449913 as a potent and orally bioavailable inhibitor of smoothened.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
66617-58-1
2462-32-0
The general procedure for the synthesis of L-phenylalanine benzyl ester hydrochloride from (S)-benzyl 2-((tert-butoxycarbonyl)amino)-3-phenylpropionate was as follows: benzyl (2S)-2-(tert-butoxycarbonylamino)-3-phenylpropionate (12.8 g, 36 mmol) was dissolved in an ether solution of 2 M HCl (90 mL) and a dioxane solution of 4 M HCl (18 mL). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was diluted with hexane (100 mL) and subsequently filtered to afford L-phenylalanine benzyl ester hydrochloride (7.98 g, 76% yield) as a white fine powder. The product was characterized by 1H NMR (CD3OD, 400 MHz): δ (ppm) 7.40-7.15 (m, 10H), 5.23 (s, 2H), 4.36-4.31 (m, 1H), 3.26-3.12 (m, 2H).
References
[1] Journal of Organic Chemistry, 2015, vol. 80, # 9, p. 4235 - 4243
[2] Patent: US9441012, 2016, B2. Location in patent: Page/Page column 67
[3] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 14, p. 1497 - 1499
[4] Journal of Enzyme Inhibition and Medicinal Chemistry, 2012, vol. 27, # 2, p. 302 - 310
[5] Chemistry - A European Journal, 2012, vol. 18, # 21, p. 6528 - 6541
L-Phenylalanine benzyl ester hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from L-Phenylalanine benzyl ester hydrochloride manufacturers
- Product
- H-L-Phe-OBzl.HCl 2462-32-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-03-18
- Product
- L-Phenylalanine benzyl ester hydrochloride 2462-32-0
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-04
- Product
- L-Phenylalanine benzyl ester hydrochloride 2462-32-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11