ChemicalBook > CAS DataBase List > L-Phenylalanine benzyl ester hydrochloride

L-Phenylalanine benzyl ester hydrochloride

Product Name
L-Phenylalanine benzyl ester hydrochloride
CAS No.
2462-32-0
Chemical Name
L-Phenylalanine benzyl ester hydrochloride
Synonyms
L-Phenylalanine Benzyl Ester HCl;Nsc522226;PHE-OBZL HCL;anine BenzyL;H-PHE-OBZL HCL;H-PHE-OBZL.HCI;H-PHE-OBZL·HCL;H-L-Phe-OBzl*HCl;PHENYLALANINE-OBZL HCL;H-Phe-OBzl hydrochloride
CBNumber
CB0330248
Molecular Formula
C16H18ClNO2
Formula Weight
291.77
MOL File
2462-32-0.mol
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L-Phenylalanine benzyl ester hydrochloride Property

Melting point:
197-200 °C
alpha 
-13 º (c=1% in 80% acetic acid)
refractive index 
-12 ° (C=1, 80% acetic acid)
storage temp. 
Inert atmosphere,Room Temperature
Water Solubility 
Soluble in water
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Crystalline Powder
color 
White to off-white
optical activity
[α]20/D 13±1°, c = 1% in acetic acid: water (4:1)
BRN 
3919200
InChI
InChI=1/C16H17NO2.ClH/c17-15(11-13-7-3-1-4-8-13)16(18)19-12-14-9-5-2-6-10-14;/h1-10,15H,11-12,17H2;1H/t15-;/s3
InChIKey
CEXFHIYDTRNBJD-AVAJOTNLNA-N
SMILES
C1(=CC=CC=C1)C[C@H](N)C(=O)OCC1C=CC=CC=1.Cl |&1:7,r|
CAS DataBase Reference
2462-32-0(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
78060
Product name
L-Phenylalanine benzyl ester hydrochloride
Purity
≥99.0% (AT)
Packaging
5g
Price
$68.67
Updated
2025/07/31
TCI Chemical
Product number
P1718
Product name
L-Phenylalanine Benzyl Ester Hydrochloride
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$31
Updated
2025/07/31
TCI Chemical
Product number
P1718
Product name
L-Phenylalanine Benzyl Ester Hydrochloride
Purity
>98.0%(HPLC)(N)
Packaging
25g
Price
$125
Updated
2025/07/31
TRC
Product number
P319445
Product name
L-Phenylalanine Benzyl Ester Hydrochloride
Packaging
5g
Price
$70
Updated
2021/12/16
Usbiological
Product number
239373
Product name
L-Phenylalanine benzyl ester hydrochloride
Packaging
5g
Price
$170
Updated
2021/12/16
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L-Phenylalanine benzyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White crystal

Uses

L-Phenylalanine Benzyl Ester Hydrochloride is a commonly used reactant for the synthesis of L-isoserine derivatives as aminopeptidase N inhibitors and PF-04449913 as a potent and orally bioavailable inhibitor of smoothened.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

66617-58-1

2462-32-0

The general procedure for the synthesis of L-phenylalanine benzyl ester hydrochloride from (S)-benzyl 2-((tert-butoxycarbonyl)amino)-3-phenylpropionate was as follows: benzyl (2S)-2-(tert-butoxycarbonylamino)-3-phenylpropionate (12.8 g, 36 mmol) was dissolved in an ether solution of 2 M HCl (90 mL) and a dioxane solution of 4 M HCl (18 mL). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was diluted with hexane (100 mL) and subsequently filtered to afford L-phenylalanine benzyl ester hydrochloride (7.98 g, 76% yield) as a white fine powder. The product was characterized by 1H NMR (CD3OD, 400 MHz): δ (ppm) 7.40-7.15 (m, 10H), 5.23 (s, 2H), 4.36-4.31 (m, 1H), 3.26-3.12 (m, 2H).

References

[1] Journal of Organic Chemistry, 2015, vol. 80, # 9, p. 4235 - 4243
[2] Patent: US9441012, 2016, B2. Location in patent: Page/Page column 67
[3] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 14, p. 1497 - 1499
[4] Journal of Enzyme Inhibition and Medicinal Chemistry, 2012, vol. 27, # 2, p. 302 - 310
[5] Chemistry - A European Journal, 2012, vol. 18, # 21, p. 6528 - 6541

L-Phenylalanine benzyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from L-Phenylalanine benzyl ester hydrochloride manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
H-L-Phe-OBzl.HCl 2462-32-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-03-18
Hebei Chuanghai Biotechnology Co., Ltd
Product
L-Phenylalanine benzyl ester hydrochloride 2462-32-0
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-04
Zhuozhou Wenxi import and Export Co., Ltd
Product
L-Phenylalanine benzyl ester hydrochloride 2462-32-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

2462-32-0, L-Phenylalanine benzyl ester hydrochlorideRelated Search:

Methyl acrylate Benzyl alcohol Topotecan hydrochloride PHENYL VALERATE L-Alanine methyl ester hydrochloride Ethyl L-phenylalaninate hydrochloride DL-Phenylalanine N-(tert-Butoxycarbonyl)-L-phenylalanine Benzyl benzoate D-Phenylalanine Benzyl bromide Phenprobamate Ethyl 3-aminopropanoate hydrochloride Tris(trimethylsilyl)phosphate Methyl L-phenylalaninate hydrochloride L-Phenylglycinol L-Phenylalanine L-Alanine isopropyl ester hydrochloride

  • benzyl 3-phenyl-L-alaninate hydrochloride
  • L-Phenylalanine Benzyl Ester HCl
  • H-PHE-OBZL·HCL
  • L-Phenylalanine benzyl ester hydrochloride≥ 99% (HPLC)
  • H-PHE-OBZL HCL
  • PHE-OBZL HCL
  • PHENYLALANINE-OBZL HCL
  • L-PHENYLALANINE BENZYL ESTER HYDROCHLORIDE
  • L-PHENYLALANINE BENZYL ESTER HYDROCHLORIDE SALT
  • H-PHE-OBZL.HCI
  • H-L-Phe-OBzl*HCl
  • Nsc522226
  • l-phenylalanine benzyl ester hydrovhloride
  • H-Phe-OBzl hydrochloride
  • benzyl (2S)-2-aMino-3-phenylpropanoate hydrochloride
  • (S)-benzyl 2-aMino-3-phenylpropanoate hydrochloride
  • Phenylalanine, benzyl ester hydrochloride
  • L-PhenylalanineBenzylEsterHydrochloride&gt
  • anine BenzyL
  • L-Phenylalanine, phenylmethyl ester, hydrochloride (1:1)
  • L-Phenylalanine benzyl ester hydrochloride USP/EP/BP
  • L-Phenylalanine Benzyl Ester Hydrochloride extrapure, 99%
  • <sc>L</sc>-Phenylalanine benzyl ester hydrochloride
  • L-Phenylalanine benzyl ester hydrochloride 99%
  • 2462-32-0
  • 462-32-0
  • 2462-30-0
  • C16H17NO2ClH
  • C6H5CH2CHNH2COOCH2C6H5HCl
  • C16H17NO2HCl
  • C6H17NO2HCl
  • Amino Acid Derivatives
  • Phenylalanine
  • Peptide Synthesis
  • Specialty Synthesis
  • Phenylalanine [Phe, F]
  • Amino Acids and Derivatives
  • Amino Acid Benzyl Esters
  • Amino Acids (C-Protected)
  • Biochemistry
  • Amino hydrochloride
  • Amino Acid Derivatives
  • Peptide Synthesis
  • Phenylalanine
  • Amino Acid Derivatives
  • Amino Acids