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L-Alanine isopropyl ester hydrochloride

Product Name
L-Alanine isopropyl ester hydrochloride
CAS No.
62062-65-1
Chemical Name
L-Alanine isopropyl ester hydrochloride
Synonyms
L-Alanine isopropyl ester HCl;Ala-OiPr.HCl;L-Ala.oipr.Hcl;anine isopropyL;Tenofovir Impurity 78;Tenofovir Impurity 14 HCl;L-Amlamine Isopropyl ester;Alanine isopropyl hydrochloride;propan-2-yl (2S)-2-aminopropanoate;L- alanine isopropyl hydrochloride
CBNumber
CB82547022
Molecular Formula
C6H14ClNO2
Formula Weight
167.63
MOL File
62062-65-1.mol
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L-Alanine isopropyl ester hydrochloride Property

Melting point:
85 °C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
Water Solubility 
Soluble in water
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
powder to crystal
color 
White to Orange to Green
optical activity
Consistent with structure
Stability:
Very Hygroscopic
InChI
InChI=1/C6H13NO2.ClH/c1-4(2)9-6(8)5(3)7;/h4-5H,7H2,1-3H3;1H/t5-;/s3
InChIKey
YAQKNCSWDMGPOY-JEDNCBNOSA-N
SMILES
C(=O)([C@@H](N)C)OC(C)C.Cl |&1:2,r|
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Safety

HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H371May cause damage to organs

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P309+P311IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2588
Product name
L-Alanine Isopropyl Ester Hydrochloride
Purity
>98.0%(T)
Packaging
5g
Price
$33
Updated
2025/07/31
TCI Chemical
Product number
A2588
Product name
L-Alanine Isopropyl Ester Hydrochloride
Purity
>98.0%(T)
Packaging
25g
Price
$97
Updated
2025/07/31
TRC
Product number
I822220
Product name
(S)-Isopropyl-2-aminopropanoateHydrochloride
Packaging
250mg
Price
$55
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK1413915
Product name
L-AlanineisopropylesterHCl
Purity
98%
Packaging
5g
Price
$56
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA30147
Product name
L-Alanine isopropyl ester HCl
Packaging
250g
Price
$65
Updated
2021/12/16
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L-Alanine isopropyl ester hydrochloride Chemical Properties,Usage,Production

Uses

L-Alanine isopropyl ester hydrochloride is a reagent used in the synthesis of anti- hepatitis C virus prodrugs based on imidazotriazine and pyrrolotriazine molecules. Further, it reacts with (1R:2R)-2-Hydroxy-πnanone-3 to prepare isopropyl (1R,2R,5R)-2′-[(2-hydroxypinan-3-ylene)amino]propanoate.

Uses

(S)-Isopropyl-2-aminopropanoate Hydrochloride, is a chemical reagent used in the synthesis of anti-HCV prodrugs based on imidazotriazine and pyrrolotriazine molecules.

Synthesis

56-41-7

67-63-0

39613-92-8

To a reaction flask equipped with a mechanical stirrer, reflux condenser tube, thermometer and under nitrogen protection was added L-alanine (5.0 g, 56.1 mmol) and 11.1% w/w isopropanol HCl solution (73.8 g, 224.5 mmol). The reaction mixture was heated to reflux temperature (80-85 °C) and kept for 4 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) using a 7:3 ethanol-water mixture as eluent and ninhydrin as color developer. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove isopropanol and isopropyl acetate, and the residual solvent was removed by multiple azeotropic distillations to give the final product (R)-isopropyl (R)-2-aminopropionate hydrochloride in oil form (9.4 g, quantitative yield).

References

[1] Patent: WO2016/151542, 2016, A1. Location in patent: Page/Page column 19
[2] European Journal of Organic Chemistry, 2018, vol. 2018, # 20, p. 2622 - 2628
[3] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 12, p. 1197 - 1201
[4] Patent: WO2015/38596, 2015, A1. Location in patent: Page/Page column 237; 238
[5] Patent: WO2016/145142, 2016, A1. Location in patent: Page/Page column 287

L-Alanine isopropyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Alanine isopropyl ester hydrochloride Suppliers

Americas 1 Belgium 1 Canada 1 China 329 Europe 1 Germany 1 India 20 Japan 2 Switzerland 1 United Kingdom 4 United States 13 Global 374
TCI Chemicals (India) Pvt. Ltd.
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View Lastest Price from L-Alanine isopropyl ester hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
L-Alanine isopropyl ester hydrochloride 62062-65-1
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
500kgs
Release date
2021-08-27
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
L-ALa-Oipr. HCL 62062-65-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-03-22
Henan Aochuang Chemical Co.,Ltd.
Product
L-Alanine isopropyl ester hydrochloride 62062-65-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-27

62062-65-1, L-Alanine isopropyl ester hydrochlorideRelated Search:

BOC-MET-OSU Sofosbuvir L-Phenylalanine benzyl ester hydrochloride Diethyl L-glutamate hydrochloride Tenofovir Impurity 95 (R)-(((1-(6-amino-3H-purin-3-yl)propan-2-yl)oxy)methyl)phosphonic acid Tenofovir Disopropyl Ethyl Diester Tenofovir D-Alanine Isopropyl Ester HCl 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-[6-[[[[9-[(2R)-5-hydroxy-2,11-diMethyl-5-oxido-9-oxo-3,6,8,10-tetraoxa-5-phosphadodec-1-yl]-9H-purin-6-yl]aMino]Methyl]aMino]-9H-purin-9-yl]-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-ox (S)-Tenofovir ChloroMethyl Propyl Carbonate Chloromethyl isopropyl carbonate rac-Tenofovir-d7 L-Alanine, N-[(R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester (3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester (2'R)-2'-Deoxy-2'-fluoro-2'-Methyl-uridine 3',5'-dibenzoate

  • propan-2-yl (2S)-2-aminopropanoate
  • Tenofovir Impurity 78
  • L-Alanine isopropyl ester hydrochloide
  • L-Alanine, 1-Methylethyl ester, hydrochloride
  • alanine isopropyl ester hydrochloride
  • L-Alanine, 1-Methylethyl ester, hydrochloride (1:1)
  • Prop-2-yl L-alaninate hydrochloride, Isopropyl (2S)-2-aminopropanoate hydrochloride, H-Ala-OiPr HCl
  • L-Alanine isopropyl ester HCl
  • (S)-2-Amino-propionic acid isopropyl ester
  • L-Ala.oipr.Hcl
  • <small>L</small>-Alanine Isopropyl Ester Hydrochloride
  • Prop-2-yl L-alaninate hydrochloride, Isopropyl (2S)-2-aminopropanoate hydrochlo
  • (S)-ISOPROPYL 2-AMINOPROPANOATE HCL
  • L-Alanine Isopropyl Ester Hydrochloride &gt
  • L- alanine isopropyl hydrochloride
  • anine isopropyL
  • Alanine, 1-methylethyl ester, hydrochloride
  • Isopropyl L-alaninate hydrochloride ?(1:1)
  • Isopropyl (S)-2-Aminopropionate Hydrochloride
  • L-Amlamine Isopropyl ester
  • L-Alanine Isopropyl Ester HydrochlorideQ: What is L-Alanine Isopropyl Ester Hydrochloride Q: What is the CAS Number of L-Alanine Isopropyl Ester Hydrochloride Q: What is the storage condition of L-Alanine Isopropyl Ester Hydrochloride Q: What are the applications of L-Alanine Isopropyl Ester Hydrochloride
  • Alanine isopropyl hydrochloride
  • Ala-OiPr.HCl
  • L-Alanine isopropyl ester hydrochloride
  • L-Alanine Isopropyl Ester HydrochlorideDiscontinued, see I822220
  • 4-bromophenyl ethyl ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
  • Tenofovir Impurity 68(Hydrochloride
  • Tenofovir Impurity 14 HCl
  • 62062-65-1