D-Alanine Isopropyl Ester HCl
- Product Name
- D-Alanine Isopropyl Ester HCl
- CAS No.
- 39613-92-8
- Chemical Name
- D-Alanine Isopropyl Ester HCl
- Synonyms
- (R)-isopropyl 2-aminopropanoate hydrochloride;D-ALa-Oipr. HCL;H-D-Ala-OiPr·HCl;H-D-Ala-OiPro.HCl;Tenofovir Impurity 7 HCl;Tenofovir Impurity 3 HCl;D-Alanine Isopropyl Ester HCl;D-Alanine 1-methylethyl ester HCl;isopropyl D-alaninate hydrochloride;(R)Isopropyl 2-amino-propanoate HCl
- CBNumber
- CB02681676
- Molecular Formula
- C6H14ClNO2
- Formula Weight
- 167.63
- MOL File
- 39613-92-8.mol
D-Alanine Isopropyl Ester HCl Property
- Melting point:
- 80-82oC
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
Safety
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- A510820
- Product name
- D-AlanineIsopropylEsterHydrochloride,~90%
- Packaging
- 10g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 259904
- Product name
- D-Alanine isopropyl ester hydrochloride
- Packaging
- 10g
- Price
- $396
- Updated
- 2021/12/16
- Product number
- AS102597
- Product name
- D-Alanine isopropyl ester HCl
- Purity
- 95%
- Packaging
- 1g
- Price
- $19
- Updated
- 2021/12/16
- Product number
- AS102597
- Product name
- D-Alanine isopropyl ester HCl
- Purity
- 95%
- Packaging
- 5G
- Price
- $43
- Updated
- 2021/12/16
- Product number
- FA30148
- Product name
- D-Alanine isopropyl ester HCl
- Packaging
- 5G
- Price
- $65
- Updated
- 2021/12/16
D-Alanine Isopropyl Ester HCl Chemical Properties,Usage,Production
Uses
D-Alanine Isopropyl Ester Hydrochloride is a chiral reagent used in the synthesis of nucleotide prodrugs such as (PSI-7977) for the treatment of hepatitis C. Also used in the preparation of synthetic sweeteners.
Synthesis
56-41-7
67-63-0
39613-92-8
To a three-necked flask equipped with a mechanical stirrer, reflux condenser, thermometer and under nitrogen protection was added L-alanine (5.0 g, 56.1 mmol) and 11.1% w/w solution of isopropanol hydrochloride (73.8 g, 224.5 mmol). The reaction mixture was heated to 80-85 °C for 4 h at reflux. The reaction process was monitored by thin layer chromatography (TLC) using 7:3 ethanol-water as the unfolding agent and ninhydrin for color development. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove isopropanol and the residue was co-evaporated with isopropyl acetate several times to give the final product (R)-isopropyl 2-aminopropionate hydrochloride in oil form (9.4 g, quantitative yield).
References
[1] Patent: WO2016/151542, 2016, A1. Location in patent: Page/Page column 19
[2] European Journal of Organic Chemistry, 2018, vol. 2018, # 20, p. 2622 - 2628
[3] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 12, p. 1197 - 1201
[4] Patent: WO2015/38596, 2015, A1. Location in patent: Page/Page column 237; 238
[5] Patent: WO2016/145142, 2016, A1. Location in patent: Page/Page column 287
D-Alanine Isopropyl Ester HCl Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from D-Alanine Isopropyl Ester HCl manufacturers
- Product
- D-ALa-Oipr. HCL 39613-92-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-02-23
- Product
- Tenofovir impurity 67 39613-92-8
- Price
- US $0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 5g
- Release date
- 2025-02-13
- Product
- D-Alanine Isopropyl Ester HCl 39613-92-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 200kg
- Release date
- 2019-08-30