ChemicalBook > CAS DataBase List > D-Alanine Isopropyl Ester HCl

D-Alanine Isopropyl Ester HCl

Product Name
D-Alanine Isopropyl Ester HCl
CAS No.
39613-92-8
Chemical Name
D-Alanine Isopropyl Ester HCl
Synonyms
(R)-isopropyl 2-aminopropanoate hydrochloride;D-ALa-Oipr. HCL;H-D-Ala-OiPr·HCl;H-D-Ala-OiPro.HCl;Tenofovir Impurity 7 HCl;Tenofovir Impurity 3 HCl;D-Alanine Isopropyl Ester HCl;D-Alanine 1-methylethyl ester HCl;isopropyl D-alaninate hydrochloride;(R)Isopropyl 2-amino-propanoate HCl
CBNumber
CB02681676
Molecular Formula
C6H14ClNO2
Formula Weight
167.63
MOL File
39613-92-8.mol
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D-Alanine Isopropyl Ester HCl Property

Melting point:
80-82oC
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
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Safety

HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
A510820
Product name
D-AlanineIsopropylEsterHydrochloride,~90%
Packaging
10g
Price
$120
Updated
2021/12/16
Usbiological
Product number
259904
Product name
D-Alanine isopropyl ester hydrochloride
Packaging
10g
Price
$396
Updated
2021/12/16
Activate Scientific
Product number
AS102597
Product name
D-Alanine isopropyl ester HCl
Purity
95%
Packaging
1g
Price
$19
Updated
2021/12/16
Activate Scientific
Product number
AS102597
Product name
D-Alanine isopropyl ester HCl
Purity
95%
Packaging
5G
Price
$43
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA30148
Product name
D-Alanine isopropyl ester HCl
Packaging
5G
Price
$65
Updated
2021/12/16
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D-Alanine Isopropyl Ester HCl Chemical Properties,Usage,Production

Uses

D-Alanine Isopropyl Ester Hydrochloride is a chiral reagent used in the synthesis of nucleotide prodrugs such as (PSI-7977) for the treatment of hepatitis C. Also used in the preparation of synthetic sweeteners.

Synthesis

56-41-7

67-63-0

39613-92-8

To a three-necked flask equipped with a mechanical stirrer, reflux condenser, thermometer and under nitrogen protection was added L-alanine (5.0 g, 56.1 mmol) and 11.1% w/w solution of isopropanol hydrochloride (73.8 g, 224.5 mmol). The reaction mixture was heated to 80-85 °C for 4 h at reflux. The reaction process was monitored by thin layer chromatography (TLC) using 7:3 ethanol-water as the unfolding agent and ninhydrin for color development. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove isopropanol and the residue was co-evaporated with isopropyl acetate several times to give the final product (R)-isopropyl 2-aminopropionate hydrochloride in oil form (9.4 g, quantitative yield).

References

[1] Patent: WO2016/151542, 2016, A1. Location in patent: Page/Page column 19
[2] European Journal of Organic Chemistry, 2018, vol. 2018, # 20, p. 2622 - 2628
[3] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 12, p. 1197 - 1201
[4] Patent: WO2015/38596, 2015, A1. Location in patent: Page/Page column 237; 238
[5] Patent: WO2016/145142, 2016, A1. Location in patent: Page/Page column 287

D-Alanine Isopropyl Ester HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from D-Alanine Isopropyl Ester HCl manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
D-ALa-Oipr. HCL 39613-92-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-02-23
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Tenofovir impurity 67 39613-92-8
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
5g
Release date
2025-02-13
Career Henan Chemical Co
Product
D-Alanine Isopropyl Ester HCl 39613-92-8
Price
US $1.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
200kg
Release date
2019-08-30

39613-92-8, D-Alanine Isopropyl Ester HClRelated Search:

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  • D-Alanine isopropylester HydrochlorideQ: What is D-Alanine isopropylester Hydrochloride Q: What is the CAS Number of D-Alanine isopropylester Hydrochloride Q: What is the storage condition of D-Alanine isopropylester Hydrochloride
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  • 39613-92-8