2'-deoxy-2'-fluoro-2'-C-methyluridine

Product Name: 2'-deoxy-2'-fluoro-2'-C-methyluridine
CAS No.: 863329-66-2
Chemical Name: 2'-deoxy-2'-fluoro-2'-C-methyluridine
Synonyms: CS-832;RO 2433;PSI-6206;GS-331007;PSI 6206 int;sofosbuvir INT;Sofosbuvir INT 1;-fluoroguanosine;-C-methyluridine;Sofosbuvir imp-11
CBNumber: CB62525846
Molecular Formula: C10H13FN2O5
Formula Weight: 260.22
MOL File: 863329-66-2.mol

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2'-deoxy-2'-fluoro-2'-C-methyluridine Property

Melting point:: 237-238℃
Density: 1.55
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
pka: 9.39±0.10(Predicted)
form: Solid
color: White to Light Beige

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Safety

HS Code: 2934.99.4400

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: D4823
Product name: (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine
Purity: >98.0%(HPLC)(T)
Packaging: 200mg
Price: $122
Updated: 2024/03/01

TCI Chemical

Product number: D4823
Product name: (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $428
Updated: 2024/03/01

Cayman Chemical

Product number: 18391
Product name: PSI-6206
Purity: ≥98%
Packaging: 50mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18391
Product name: PSI-6206
Purity: ≥98%
Packaging: 100mg
Price: $61
Updated: 2024/03/01

Usbiological

Product number: 158336
Product name: 1-[[2'-
Packaging: 1mg
Price: $496
Updated: 2021/12/16

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2'-deoxy-2'-fluoro-2'-C-methyluridine Chemical Properties,Usage,Production

Description

(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine / PSI-6206 is the deaminated metabolite of β-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine, an effective inhibitor of hepatitis C virus (HCV) RNA polymerase.

Uses

RO 2433 is the deaminated metabolite of β-D-2''-Deoxy-2''-fluoro-2''-C-methylcytidine, an effective inhibitor of hepatitis C virus (HCV) replication in vitro.

Biological Activity

psi-6206 (as known as ro-2433 or gs-331007), β-d-2’-deoxy-2’-fluoro-2’-c-methyluridine, is the deaminated derivative of psi-6130, β-d-2’-deoxy-2’-fluoro-2’-c-methylcytidine, which is a potent inhibitor of hepatitis c virus (hcv) replication in the subgenomic hcv reolicon system. psi-6206, itself, does not shown any inhibitory activity towards hcv replication in the hcv subgenomic replicon system. however, the its triphosphate form, ro2433-tp, is a potent inhibitor of rna synthesis by hcv polymerase, which inhibits both the rna sysnthesis activity of hcv replicase (ic50 = 1.19 um) and the rna synthesis activity of the recombinant hcv con1 ns58 on a heteropolymeric rna template derived from the 3’-end of the negative strand of the hcv genome (ic50 = 0.52 um and ki = 0.141 um).han ma, wen-rong jiang, nicole robledo, vincent leveque, samir ali, teresa lara-jamie, mohammad masjedizadeh, david b. smith, nick cammack, klaus klumpp, and julian symons. characterization of the metabolic ctivation of hepatitis c virus nucleoside inhibitor β-d-2’-deoxy-2’-fluoro-2’-c-methylcytidine (psi-6130) and identification of a novel active 5’-triphosphate species. the journal of biological chemistry 2007; 282(41): 29812-29820

target

HCV

2'-deoxy-2'-fluoro-2'-C-methyluridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-deoxy-2'-fluoro-2'-C-methyluridine Suppliers

Americas 1 China 360 Europe 1 France 1 Germany 1 India 24 Japan 1 Jordan 1 United Kingdom 1 United States 33 Global 424

Shanghai Rochi Pharmaceutical Co., Ltd.

Tel: 021-38751876 15000076078
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Email: Info@rochipharma.com
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R.R Scientific, LLC.

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Chemvon Biotechnology Co., Ltd

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Chembest Research Laboratories Limited

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Energy Chemical

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Adamas Reagent, Ltd.

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Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
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Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
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View Lastest Price from 2'-deoxy-2'-fluoro-2'-C-methyluridine manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2'-deoxy-2'-fluoro-2'-C-methyluridine 863329-66-2
Price: US $8.00-2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-25

airuikechemical co., ltd.

Product: 2′-deoxy-2′-fluoro-2′-c-methyluridine 863329-66-2
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-08

Nanjing Fred Technology Co., Ltd

Product: 2'-deoxy-2'-fluoro-2'-C-methyluridine 863329-66-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2024-01-04

863329-66-2, 2'-deoxy-2'-fluoro-2'-C-methyluridineRelated Search:

Sofosbuvir Impurity29 PSI-7976 Sofosbuvir Impurity13 1-((2R,3R,4R,5R)-3-chloro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione SofosBuvir impurity 44 Donepezil Erythromycin thiocyanate L-Alanine, N-[(R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester (3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester L-Alanine isopropyl ester hydrochloride (2'R)-2'-Deoxy-2'-fluoro-2'-Methyl-uridine 3',5'-dibenzoate PSI-6130 derivative D-Arabinonic acid, 2-C-methyl-4,5-O-(1-methylethylidene)-,ethyl ester ((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate Sofosbuvir alpha-D-erythro-Pentofuranous-2-ulose 1,3,5-tribenzoate Sofosbuvir Impurity23

2'-deoxy-2'-fluoro-2'-C-methyluridine

2'-Deoxy-2-floro-2'Methyl-uridine

1-((2S,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione

1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione

PSI-6206

RO 2433

Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)-

Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- PSI6206

(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine

5. (2'R)-2'-Deoxy-2'-fluoro-2'-Methyluridine

2'-deoxy-2'-fluoro-2'-C-Methyluridine　(N-1)

1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione RO 2433

1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

β-D-2'-deoxy-2'-α-F-2'-β-C-methyluridine

Sofosbuvir Intermediate 4

Sofosbuvir INT 1

Sofosbuvir int. N-1

2'-deoxy-2'-fluoro-2'-methyluridine

1-[(2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-2-yl]pyrimidine-2,4-dione

Sofosbuvir Nucleoside Derivative (GS-331007)

Sofosbuvir Intermediates 2

(2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine

-fluoro-b-D-ribofuranosyl)purine

-biphenyl-4-yl)methyl]-2-ethoxy-7-benzimidazolecarboxylic Acid Methyl Ester

-fluoro-b-D-arabinofuranosyl)guanine

-biphenyl-4-yl)methyl]-2-ethoxy-d5-7-benzimidazolecarboxylic Acid Methyl Ester

-deoxy-6-methoxyguanosine

-fluoro-b-D-ribofuranosyl)-2-fluoroadenine

-deoxy-7-iodoadenosine

-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic Acid

PSI-6206 (RO 2433)

GS-331007

PSI 6206 int

(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine (Sofo C1)

-fluoro-b-D-ribofuranosyl)-isoguanine

-fluoroguanosine

-chloro-b-L-arabinofuranosyl)-thymine

-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester

Sofosbuvir imp-11

-deoxy-O6-methylguanosine

-fluoro-b-L-arabinofuranosyl)-uracil

-O-trityl-b-L-arabinofuranosyl)-uracil

-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic Acid-d5

PSI-6206; RO-2433; PSI6206; RO2433

CS-832

2'-Deoxy-2'-F-2'-C-methyluridine

-C-methyluridine

-fluoro-beta-d-arabinofuranosyl)-5-ethyluracil

-C-ethynyladenosine

-fluoro-b-D-arabinofuranosyl)purine

-fluoro-b-D-arabinofuranosyl)cytosine

-fluoro-b-D-arabinofuranosyl)adenine

-fluoro-b-D-arabinofuranosyl)-5-ethyluracil

-deoxy-7-iodoguanosine

-fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine

-O-4-C-Methylene-b-D-ribofuranosyl)thymine

-fluoro-b-D-arabinofuranosyl)cytosine HCl

-fluoro-b-D-arabinofuranosyl)hypoxantine