ChemicalBook > CAS DataBase List > 2'-deoxy-2'-fluoro-2'-C-methyluridine

2'-deoxy-2'-fluoro-2'-C-methyluridine

Product Name
2'-deoxy-2'-fluoro-2'-C-methyluridine
CAS No.
863329-66-2
Chemical Name
2'-deoxy-2'-fluoro-2'-C-methyluridine
Synonyms
CS-832;RO 2433;PSI-6206;GS-331007;PSI 6206 int;sofosbuvir INT;Sofosbuvir INT 1;-fluoroguanosine;-C-methyluridine;Sofosbuvir imp-11
CBNumber
CB62525846
Molecular Formula
C10H13FN2O5
Formula Weight
260.22
MOL File
863329-66-2.mol
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2'-deoxy-2'-fluoro-2'-C-methyluridine Property

Melting point:
237-238℃
Density 
1.55
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
pka
9.39±0.10(Predicted)
form 
Solid
color 
White to Light Beige
InChI
InChI=1S/C10H13FN2O5/c1-10(11)7(16)5(4-14)18-8(10)13-3-2-6(15)12-9(13)17/h2-3,5,7-8,14,16H,4H2,1H3,(H,12,15,17)/t5-,7-,8-,10-/m1/s1
InChIKey
ARKKGZQTGXJVKW-VPCXQMTMSA-N
SMILES
OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@@](F)(C)[C@@H]1O
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Safety

HS Code 
2934.99.4400
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
D4823
Product name
(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine
Purity
>98.0%(HPLC)(T)
Packaging
200mg
Price
$110
Updated
2025/07/31
TCI Chemical
Product number
D4823
Product name
(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$385
Updated
2025/07/31
Cayman Chemical
Product number
18391
Product name
PSI-6206
Purity
≥98%
Packaging
50mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
18391
Product name
PSI-6206
Purity
≥98%
Packaging
100mg
Price
$61
Updated
2024/03/01
TRC
Product number
R637200
Product name
RO2433
Packaging
250mg
Price
$220
Updated
2021/12/16
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2'-deoxy-2'-fluoro-2'-C-methyluridine Chemical Properties,Usage,Production

Description

(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine / PSI-6206 is the deaminated metabolite of β-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine, an effective inhibitor of hepatitis C virus (HCV) RNA polymerase.

Uses

RO 2433 is the deaminated metabolite of β-D-2''-Deoxy-2''-fluoro-2''-C-methylcytidine, an effective inhibitor of hepatitis C virus (HCV) replication in vitro.

Biological Activity

psi-6206 (as known as ro-2433 or gs-331007), β-d-2’-deoxy-2’-fluoro-2’-c-methyluridine, is the deaminated derivative of psi-6130, β-d-2’-deoxy-2’-fluoro-2’-c-methylcytidine, which is a potent inhibitor of hepatitis c virus (hcv) replication in the subgenomic hcv reolicon system. psi-6206, itself, does not shown any inhibitory activity towards hcv replication in the hcv subgenomic replicon system. however, the its triphosphate form, ro2433-tp, is a potent inhibitor of rna synthesis by hcv polymerase, which inhibits both the rna sysnthesis activity of hcv replicase (ic50 = 1.19 um) and the rna synthesis activity of the recombinant hcv con1 ns58 on a heteropolymeric rna template derived from the 3’-end of the negative strand of the hcv genome (ic50 = 0.52 um and ki = 0.141 um).han ma, wen-rong jiang, nicole robledo, vincent leveque, samir ali, teresa lara-jamie, mohammad masjedizadeh, david b. smith, nick cammack, klaus klumpp, and julian symons. characterization of the metabolic ctivation of hepatitis c virus nucleoside inhibitor β-d-2’-deoxy-2’-fluoro-2’-c-methylcytidine (psi-6130) and identification of a novel active 5’-triphosphate species. the journal of biological chemistry 2007; 282(41): 29812-29820

target

HCV

2'-deoxy-2'-fluoro-2'-C-methyluridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-deoxy-2'-fluoro-2'-C-methyluridine Suppliers

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View Lastest Price from 2'-deoxy-2'-fluoro-2'-C-methyluridine manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
2'-deoxy-2'-fluoro-2'-C-methyluridine 863329-66-2
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-11-26
RongNa Biotechnology Co.,Ltd
Product
2'-deoxy-2'-fluoro-2'-C-methyluridine 863329-66-2
Price
US $10.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
10 ton
Release date
2025-08-22
Wuhan JiyunZen Tech Co., Ltd.
Product
2'-deoxy-2'-fluoro-2'-C-methyluridine 863329-66-2
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99% hplc
Supply Ability
500TONS
Release date
2025-05-14

863329-66-2, 2'-deoxy-2'-fluoro-2'-C-methyluridineRelated Search:

Sofosbuvir Impurity29 PSI-7976 Sofosbuvir Impurity13 1-((2R,3R,4R,5R)-3-chloro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione SofosBuvir impurity 44 Donepezil Erythromycin thiocyanate L-Alanine, N-[(R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester (3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester L-Alanine isopropyl ester hydrochloride (2'R)-2'-Deoxy-2'-fluoro-2'-Methyl-uridine 3',5'-dibenzoate PSI-6130 derivative D-Arabinonic acid, 2-C-methyl-4,5-O-(1-methylethylidene)-,ethyl ester ((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate Sofosbuvir alpha-D-erythro-Pentofuranous-2-ulose 1,3,5-tribenzoate Sofosbuvir Impurity23

  • 2'-deoxy-2'-fluoro-2'-C-methyluridine
  • 2'-Deoxy-2-floro-2'Methyl-uridine
  • 1-((2S,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
  • 1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
  • PSI-6206
  • RO 2433
  • Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)-
  • Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- PSI6206
  • (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine
  • 5. (2'R)-2'-Deoxy-2'-fluoro-2'-Methyluridine
  • 2'-deoxy-2'-fluoro-2'-C-Methyluridine　(N-1)
  • 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione RO 2433
  • 1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
  • β-D-2'-deoxy-2'-α-F-2'-β-C-methyluridine
  • Sofosbuvir Intermediate 4
  • Sofosbuvir INT 1
  • Sofosbuvir int. N-1
  • 2'-deoxy-2'-fluoro-2'-methyluridine
  • 1-[(2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-2-yl]pyrimidine-2,4-dione
  • Sofosbuvir Nucleoside Derivative (GS-331007)
  • Sofosbuvir Intermediates 2
  • (2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine
  • -fluoro-b-D-ribofuranosyl)purine
  • -biphenyl-4-yl)methyl]-2-ethoxy-7-benzimidazolecarboxylic Acid Methyl Ester
  • -fluoro-b-D-arabinofuranosyl)guanine
  • -biphenyl-4-yl)methyl]-2-ethoxy-d5-7-benzimidazolecarboxylic Acid Methyl Ester
  • -deoxy-6-methoxyguanosine
  • -fluoro-b-D-ribofuranosyl)-2-fluoroadenine
  • -deoxy-7-iodoadenosine
  • -biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic Acid
  • PSI-6206 (RO 2433)
  • GS-331007
  • PSI 6206 int
  • (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine (Sofo C1)
  • -fluoro-b-D-ribofuranosyl)-isoguanine
  • -fluoroguanosine
  • -chloro-b-L-arabinofuranosyl)-thymine
  • -biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
  • Sofosbuvir imp-11
  • -deoxy-O6-methylguanosine
  • -fluoro-b-L-arabinofuranosyl)-uracil
  • -O-trityl-b-L-arabinofuranosyl)-uracil
  • -biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic Acid-d5
  • PSI-6206; RO-2433; PSI6206; RO2433
  • CS-832
  • 2'-Deoxy-2'-F-2'-C-methyluridine
  • -C-methyluridine
  • -fluoro-beta-d-arabinofuranosyl)-5-ethyluracil
  • -C-ethynyladenosine
  • -fluoro-b-D-arabinofuranosyl)purine
  • -fluoro-b-D-arabinofuranosyl)cytosine
  • -fluoro-b-D-arabinofuranosyl)adenine
  • -fluoro-b-D-arabinofuranosyl)-5-ethyluracil
  • -deoxy-7-iodoguanosine
  • -fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine
  • -O-4-C-Methylene-b-D-ribofuranosyl)thymine
  • -fluoro-b-D-arabinofuranosyl)cytosine HCl
  • -fluoro-b-D-arabinofuranosyl)hypoxantine