Dexamethasone-17-acetate

Product Name: Dexamethasone-17-acetate
CAS No.: 1177-87-3
Chemical Name: Dexamethasone-17-acetate
Synonyms: DEXAMETHASONE ACETATE;DEXAMETHASON ACETATE;DEXAMETHASONE 21-ACETATE;9-fluoro-11β,17-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate;Dectan;Panasone;Dectancyl;NSC 39471;Decadronal;Decadron-la
CBNumber: CB9703269
Molecular Formula: C24H31FO6
Formula Weight: 434.5
MOL File: 1177-87-3.mol

More

Less

Dexamethasone-17-acetate Property

Melting point:: 238-240 °C(lit.)
alpha: D25 +73° (chloroform) (Arth, 1958); D +77.6° (Oliveto)
Boiling point:: 579.4±50.0 °C(Predicted)
Density: 1.1517 (estimate)
refractive index: 87 ° (C=1, Dioxane)
storage temp.: 2-8°C
solubility: Soluble at 100 mg/ml in acetone
form: Powder
pka: 12.08±0.70(Predicted)
color: White
Water Solubility: 13mg/L(25 ºC)
Merck: 2943
BRN: 2342608
CAS DataBase Reference: 1177-87-3(CAS DataBase Reference)
NIST Chemistry Reference: Prednisolone, 9alpha-fluoro-16alpha-methyl-, acetate(1177-87-3)
EPA Substance Registry System: Dexamethasone-21-acetate (1177-87-3)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 43
Safety Statements: 36/37
WGK Germany: 3
RTECS: TU4050000
TSCA: Yes
HS Code: 29372290

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1176506
Product name: Dexamethasone acetate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: 46166
Product name: Dexamethasone 21-acetate
Purity: VETRANAL
Packaging: 100mg
Price: $81.7
Updated: 2022/05/15

Alfa Aesar

Product number: J63691
Product name: Dexamethasone acetate
Packaging: 1g
Price: $186
Updated: 2024/03/01

Alfa Aesar

Product number: J63691
Product name: Dexamethasone acetate
Packaging: 5g
Price: $666
Updated: 2024/03/01

Cayman Chemical

Product number: 22286
Product name: Dexamethasone Acetate
Purity: ≥98%
Packaging: 100mg
Price: $33
Updated: 2024/03/01

More

Less

Dexamethasone-17-acetate Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Originator

Dexacen,Central,US,1977

Uses

Protected Dexamethasone, a glucocorticoid anti-inflammatory agent.

Uses

Dexamethasone has many uses in the treatment of cancer. Dexamethasone relieves inflammation in various parts of the body. To treat or prevent allergic reactions. As treatment of certain kinds of autoimmune diseases, skin conditions, asthma and other lung conditions. As treatment for a variety of cancers, such as leukemia, lymphoma, and multiple myeloma. It is also used for replacement therapy in adrenal insufficiency and in a screening test for the diagnosis of cushing's syndrome. Dexamethasone Acetate has also been determined to markedly decrease the number of activated macrophages. In addition, Dexamethasone Acetate has been observed to significantly decrease mRNA levels of TPH2 (tryptophan hydroxylase-2) in the raphe nuclei of C57/Bl6 mice.

Uses

Dexamethasone acetate is used as a pharmaceutical primary standard to quantify the analyte in pharmaceutical formulations using chromatography ttechniques.

Definition

ChEBI: Dexamethasone acetate is a corticosteroid hormone.

Manufacturing Process

The preparation of dexamethasone acetate is described in US Patent 3,007,923 as follows. 1.5 cc of dimethylformamide and 1.5 cc of anhydrous hydrofluoric acid are admixed and treated with 480 mg of 9β,11β-epoxy-17αhydroxy-21-acetoxy-16α-methyl-?1,4-pregnadiene-3,20-dione (prepared according to E.P. Oliveto et al, J. Am. Chem. Soc., 80, 44331, 1958). The steroid dissolves in about 15 minutes. The reaction mixture is shaken for two hours at a temperature between 0 and +5°C, and then poured into 75 cc of
water containing in suspension, 7.5 grams of sodium bicarbonate. The mixture is vacuum filtered, the filter cake washed and then dried at 100°C, yielding 460 mg of crude hexadecadrol contaminated with a small amount of the starting material. A single recrystallization from methylene chloride yields 370 mg of the pure product having a melting point of 170°C and 229°C. The mother liquor yields 62 mg of the starting material, and a remainder constituting a mixture of starting and final materials with little other contamination.

brand name

Decadron (Merck).

Therapeutic Function

9-Fluoro-11β,17-dihydroxy-21-acetoxy-16α-methylpregna1,4-diene-3,20-dione

Safety Profile

Experimental teratogenic and reproductive effects. A steroid. When heated to decomposition it emits toxic fumes of F-.

Purification Methods

Dexamethasone 21-acetate is purified on neutral Al2O3 using CHCl3 as eluent, the fractions are evaporated, and the residue is recrystallised from CHCl3. It has max at 239nm. [Oliveto et al. J Am Chem Soc 8 0 4431 1958]. [Beilstein 8 IV 3501.]

Dexamethasone-17-acetate Preparation Products And Raw materials

Raw materials

Progesterone Ethylene glycol Hydrogen fluoride Methyl bromide

Preparation Products

9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione21-phosphate piperazine salt

More

Less

Dexamethasone-17-acetate Suppliers

Belgium 2 Brazil 3 Canada 2 China 393 Czech Republic 2 Egypt 1 Europe 3 France 4 Germany 6 Greece 1 India 30 Italy 2 Japan 4 Malaysia 2 Poland 1 South Korea 1 Spain 2 Switzerland 1 The Netherlands 1 United Kingdom 12 United States 51 Global 524

Hubei Qibu New Material Technology Co., Ltd.

Tel: 0715-8890696 18062324989 18062324989
Email: 2284979616@qq.com
Country: China
ProdList: 519
Advantage: 58

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15396
Advantage: 58

Jinan Wald Chemical Co., Ltd.

Tel: 0531-88773586 13210588999
Fax: 053188773586
Email: 304264064@qq.com
Country: China
ProdList: 193
Advantage: 58

Jiangxi ravel Biotechnology Co.,Ltd

Tel: 400-880-2824 15608648206
Email: 1987516016@qq.com
Country: China
ProdList: 2543
Advantage: 58

Wuhan Zenuo Biopharmaceutical Technology Co., Ltd

Tel: 027-87781970 15172508891
Email: 1505560767@qq.com
Country: China
ProdList: 130
Advantage: 58

Shandong Yuhe Pharmaceutical Technology Co., LTD

Tel: 15263077727
Fax: QQ：2938966534
Email: 1436425847@qq.com
Country: China
ProdList: 165
Advantage: 58

Hubei Henghua Technology Co., Ltd.

Tel: 18064208139
Email: 2912268575@qq.com
Country: China
ProdList: 1296
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40241
Advantage: 62

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

More

Less

View Lastest Price from Dexamethasone-17-acetate manufacturers

Wuhan Haorong Biotechnology Co.,Ltd

Product: Dexamethasone-17-acetate 1177-87-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000
Release date: 2023-07-27

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Dexamethasone Acetate 1177-87-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2024-04-22

Shaanxi Haibo Biotechnology Co., Ltd

Product: Dexamethasone-17-acetate 1177-87-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-09-05

1177-87-3, Dexamethasone-17-acetateRelated Search:

Dexamethasone 21-phosphate disodium salt 9-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 17-valerate Dexamethasone palmitate Dexamethasone-d5 DexaMethasone β-D-Glucuronide SodiuM Salt Desoximetasone DEXAMETHASONE SODIUM PHOSPHATE Dexamethasone EP Impurity E Dexamethasone Impurity I 1,2-Dihydro DesoxyMetasone Dexamethasone 9,11-epoxide Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-[(3-sulfobenzoyl)oxy]-, monosodium salt, (11beta,16alpha)- Dexamethasone 21-Propionate PSXDNQUHAFMVPT-NWQAGDSVSA-N Dexamethasone-17,20 21-Aldehyde dexamethasone 21-(3-phenylpropionate) Dexamethasone 17-propionate 17,21-Dihydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate

20-dione,9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-pregna-4-diene-3

9alpha-Fluoro-16alpha-methylprednisolone acetate

9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione21-acetate

9-Fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate

9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione

9-Fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-acetate

9-Fluoro-11-beta,17,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione acetate

Dalalone D.P.

Dalalone L.A.

Decadronal

Decadron-L.A.

Decadron-la

Dectan

Dectancyl

Dexacortisyl

Dex-Cortidelt acetate

Fortecortin

Fortecortin (crystal suspension)

9α-Fluoro-16α-methylprednisolone-21-acetate, Prednisolone F acetate, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate

Dexamethasone Acetate, Anhydrous, Micronized

21-Acetoxy-9α-fluoro-11β,17α-dihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione

9-Fluoro-3,20-dioxo-16α-methylpregna-1,4-diene-11β,17,21-triol 21-acetate

Dexametasone acetate

MPB Dexamethasone-21-acetate

21-O-Acetyl Dexamethasone

9α-Fluoro-16α-methylprednisolone-21-acetate, Prednisolone F acetate

Dexamethasone 21-acetate,9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate, 9α-Fluoro-16α-methylprednisolone-21-acetate, Prednisolone F acetate

Dexamethasone Acetate (200 mg)

Dexamethasone Acetate (200 mg)H0E3390.996mg/mg(dr)

Dexamethasone-17-ace

9-ALPHA -FLUORO-11BETA 17ALPHA 21-TRIHYDROXY-16ALPHA -METHYL-1 4-PREGNADIENE-3 20-DIONE

2-((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-triMethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

Dexamethasone 21-Acetate Solution, 100ppm

Dexamethasone Acetate Dexamethasoneacetate dexamethasone-21-acetate

DEXAMETHASON ACETATE

dexamethasone-17-acetate

DEXAMETHASONE 21-ACETATE

DEXAMETHASONE ACETATE

1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE

PREDNISOLONE F ACETATE

9ALPHA-FLUORO-16ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE-21-ACETATE

9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA,17-ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE ACETATE

9ALPHA-FLUORO-16ALPHA-METHYLPREDNISOLONE-21-ACETATE

9 ALPHA-FLUORO-11 BETA,17 ALPHA,21-TRIHYDRO-16 ALPHA-METHYLPREGNA-1,4-DIENE-3,20-DIONE-21-ACETATE

9a-fluoro-16a-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate

Panasone

Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11beta,16alpha)-

Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16alpha-methyl-, 21-acetate

Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16alpha-methyl-, acetate

DEXAMETHASON 21-ACETATE VETRANAL, 250 MG

DEXAMETHASONE ACETATE EPD(CRM STANDARD)

DEXAMETHASONE ACETATE USP(CRM STANDARD)

DEXAMETHASONE ACETATE WHO(CRM STANDARD)

DEXAMETHASONE 21-ACETATE, USP

9α-fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate

DEXAMETHASONEACETATE,ANHYDROUS,MICRONIZED,USP

16α-Methyl-9α-fluoroprednisolone 21-acetate

NSC 39471