Dexamethasone-d5
- Product Name
- Dexamethasone-d5
- CAS No.
- 358731-91-6
- Chemical Name
- Dexamethasone-d5
- Synonyms
- Corson-d5;Decalix-d5;Decasone-d5;Decadron-d5;DecaderM-d5;Decacort-d5;Dekacort-d5;CortisuMMan-d5;Aeroseb-Dex-d5;Dexamethasone-d5
- CBNumber
- CB02508546
- Molecular Formula
- C22H29FO5
- Formula Weight
- 392.4610632
- MOL File
- 358731-91-6.mol
Dexamethasone-d5 Property
- Melting point:
- 230-232°C
- storage temp.
- -20°C Freezer
- solubility
- Dioxane (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- color
- Off-White to Pale Yellow
N-Bromosuccinimide Price
- Product number
- D298802
- Product name
- Dexamethasone-d5
- Packaging
- 1mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 008818
- Product name
- Dexamethasone-d5
- Packaging
- 1mg
- Price
- $566
- Updated
- 2021/12/16
- Product number
- RDL0007298
- Product name
- DEXAMETHASONE-D5
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $1045.28
- Updated
- 2021/12/16
- Product number
- D69282
- Product name
- Dexamethasone-d5
- Packaging
- 1mg
- Price
- $490
- Updated
- 2021/12/16
- Product number
- RDL0007298
- Product name
- DEXAMETHASONE-D5
- Purity
- 95.00%
- Packaging
- 2.5MG
- Price
- $2135
- Updated
- 2021/12/16
Dexamethasone-d5 Chemical Properties,Usage,Production
Chemical Properties
White to Off-White Solid
Uses
Dexamethasone-d5 is the deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses[1][2].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] LaLone CA, et al. Effects of a glucocorticoid receptor agonist, Dexamethasone, on fathead minnow reproduction, growth, and development. Environ Toxicol Chem. 2012 Mar;31(3):611-22. DOI:10.1002/etc.1729
[3] Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127(4):1003-11 DOI:10.1038/sj.bjp.0702613
[4] Rocksén D, et al. Differential anti-inflammatory and anti-oxidative effects of Dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation. Clin Exp Immunol. 2000 Nov;122(2):249-56 DOI:10.1046/j.1365-2249.2000.01373.x
[5] Roussel D, et al. Dexamethasone treatment specifically increases the basal proton conductance of rat liver mitochondria. FEBS Lett. 2003 Apr 24;541(1-3):75-9. DOI:10.1016/s0014-5793(03)00307-7
[6] Ballabh P, et al. Neutrophil and monocyte adhesion molecules in bronchopulmonary dysplasia, and effects of corticosteroids. Arch Dis Child Fetal Neonatal Ed. 2004 Jan;89(1):F76-83. DOI:10.1136/fn.89.1.f76
[7] Heidi Ledford. et al. Coronavirus Breakthrough: Dexamethasone Is First Drug Shown to Save Lives. Nature. 2020 Jun 16. DOI:10.1038/d41586-020-01824-5
[8] Yun Chen, et al. Glucocorticoids inhibit production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses. Int J Clin Exp Pathol 2018;11(7):3391-3397.
Dexamethasone-d5 Preparation Products And Raw materials
Raw materials
Preparation Products
Dexamethasone-d5 Suppliers
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