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Desoximetasone

Product Name
Desoximetasone
CAS No.
382-67-2
Chemical Name
Desoximetasone
Synonyms
Desoximethasone;DESOXYMETASONE;desoxymethasone;r2113;Stidex;a41304;HOE 304;topicorte;Topisolon;Desoximetason
CBNumber
CB0346960
Molecular Formula
C22H29FO4
Formula Weight
376.46
MOL File
382-67-2.mol
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Desoximetasone Property

Melting point:
213-215°C
alpha 
D +109° (chloroform)
Boiling point:
532.3±50.0 °C(Predicted)
Density 
376.46
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
12.98±0.10(Predicted)
form 
Solid
color 
White to Off-White
CAS DataBase Reference
382-67-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38-40-43
Safety Statements 
22-26-36
WGK Germany 
3
RTECS 
TU3834000
HS Code 
29147000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

H351Suspected of causing cancer

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D5515
Product name
Desoximetasone
Packaging
50MG
Price
$150
Updated
2024/03/01
TCI Chemical
Product number
D5515
Product name
Desoximetasone
Packaging
250MG
Price
$451
Updated
2024/03/01
Cayman Chemical
Product number
23945
Product name
Desoximetasone
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
23945
Product name
Desoximetasone
Purity
≥98%
Packaging
5mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
23945
Product name
Desoximetasone
Purity
≥98%
Packaging
10mg
Price
$172
Updated
2024/03/01
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Desoximetasone Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Originator

Topicorte,Roussel,France,1968

Definition

ChEBI: Dexamethasone in which the hydroxy group at the 17alpha position is substituted by hydrogen. A synthetic corticosteroid with glucocorticoid activity, it is used as an anti-inflammatory and anti-pruritic in the treatment of various skin dis rders, including skin allergies and psoriasis.

Manufacturing Process

(a) Production of 16α-Methyl-4-Pregnene-11β,21-diol-3,20-Dione (= 16αMethylcorticosterone): A fermenter of stainless steel having a 50 liter capacity is charged with 30 liters of a nutrient solution containing:
sterilized for ? hour at 120°C and after cooling, inoculated with a spore suspension of Curvularia lunata which is obtained by rinsing a seven day corn culture (15 grams corn) with approximately 100 cc of physiological sodium chloride solution.
After two days of culturing at 25°C under stirring (220 revolutions per minute) and ventilating (1.65 m3/hr), 18 liters of the obtained culture are removed under sterile conditions and introduced into a fermenter of the same size charged with 28.2 liters of a nutrient solution containing:
After 24 hours cultivation under stirring and ventilation as described above, 7.5 grams of 16α-methyldesoxycorticosterone, obtained by saponification of the corresponding 21-acetate and melting at 102-104°C, in 200 cc of ethanol are added and fermented under the same conditions for 28 hours.
The course of the fermentation is tested by removal of samples, which are extracted with methyl isobutyl ketone. The extract is analyzed by paper chromatography in a system of dioxane + toluene/propylene glycol.
After the end of the fermentation (28 hours) the culture broth is filtered off by suction over a large suction filter. The mycel residue is washed with water several times. The filtrate is extracted three times, each time with 10 liters of methyl isobutyl ketone. The extract is concentrated under vacuum in a circulating evaporator and in a round flask carefully dried under vacuum. The residue is crystallized from acetone/isopropyl ether. The melting point is 157- 158°C (fermentation yield = 60%). The pure product yield obtained after a second crystallization and chromatography of the mother liquor on silica gel amounts to 53% of the theoretical.
(b) 16α-Methyl-9α-Fluoro-?4-Pregnene-11β,21-Diol-3,20-Dione: 7.5 grams of 16α-methyl-9α-fluoro-?4-pregnene-21-ol-3,20-dione-21-acetate, obtained from Step (a) by acetylating with acetic anhydride in pyridine followed by reaction with HF in pyridine at 0°C, are fermented for 36 hours with Curvularia lunata (Mutant NRRL 2380), whereby the 21-acetate group is simultaneously saponified, and then further worked up. The residue is extracted with MIBK, subjected to chromatography on silica gel and there is obtained from chloroform/ethyl acetate (2:1) an eluate containing the 11βhydroxy compound, which is further dehydrogenated as the crude product.
(c) 16α-Methyl-9α-Fluoro-?1,4-Pregnadiene-11β,21-Diol-3,20-Dione: 16αmethyl-9α-fluoro-β4-pregnene-11β,21-diol-3,20-dione obtained as the crude product under Step (b) above, is fermented with Bacillus lentus for 30 hours and further worked up. The residue is extracted with methyl isobutyl ketone and there is obtained as the crude product 16α-methyl-9α-fluoro-?1,4- pregnadiene-11β,21-diol-3,20-dione.

brand name

Topicort (Taro) [Name previously used: Desoxymethasone.].

Therapeutic Function

Antiinflammatory

General Description

Desoximetasone, 9-fluoro-11β, 21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione, like clocortolone pivalate, lacks a C17α OH group inits structure.

Desoximetasone Preparation Products And Raw materials

Raw materials

Preparation Products

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Desoximetasone Suppliers

GUANGZHOU TOPWORK CHEMISTRY CO.,LTD.
Tel
020-87317062 13048089691
Email
852378519@qq.com
Country
China
ProdList
155
Advantage
58
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5050
Advantage
50
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
T&W GROUP
Tel
021-61551611 13296011611
Fax
+86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-83725681-603
Fax
+86 755 28094224
Country
China
ProdList
4496
Advantage
50
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View Lastest Price from Desoximetasone manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Desoximetasone 382-67-2
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%
Supply Ability
1kg/month
Release date
2023-02-17
Shaanxi Dideu Medichem Co. Ltd
Product
Desoximetasone 382-67-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20T
Release date
2024-07-02
Zhuozhou Wenxi import and Export Co., Ltd
Product
Desoximetasone 382-67-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

382-67-2, DesoximetasoneRelated Search:


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  • 382-67-2
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