ChemicalBook > CAS DataBase List > DEXAMETHASONE SODIUM PHOSPHATE

DEXAMETHASONE SODIUM PHOSPHATE

Product Name
DEXAMETHASONE SODIUM PHOSPHATE
CAS No.
312-93-6
Chemical Name
DEXAMETHASONE SODIUM PHOSPHATE
Synonyms
EGP437;EGP 437;EGP-437;wymesone;neodecadron;betnelanphosphate;oradexonphosphate;Hexadrol phosphate;examethasonephosphate;dexamethasonephosphate
CBNumber
CB0500878
Molecular Formula
C22H30FO8P
Formula Weight
472.44
MOL File
312-93-6.mol
More
Less

DEXAMETHASONE SODIUM PHOSPHATE Property

Melting point:
154-157°C
Boiling point:
669.6±65.0 °C(Predicted)
Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under Inert Atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
1.67±0.10(Predicted)
form 
Solid
color 
White to Light Brown
Stability:
Hygroscopic, Moisture Sensitive
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
62
HS Code 
2937220000
Toxicity
dni-rat-ipr 3 mg/kg JOENAK 62,527,74
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1628
Product name
Dexamethasone Phosphate
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500mg
Price
$342
Updated
2024/03/01
Sigma-Aldrich
Product number
1177000
Product name
Dexamethasone phosphate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$261.6
Updated
2024/03/01
TRC
Product number
D298835
Product name
Dexamethasone Phosphate
Packaging
25mg
Price
$105
Updated
2021/12/16
Matrix Scientific
Product number
096162
Product name
Dexamethasone 21-phosphate
Purity
95+%
Packaging
250mg
Price
$742
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0005112
Product name
DEXAMETHASONE PHOSPHATE
Purity
95.00%
Packaging
25MG
Price
$750.75
Updated
2021/12/16
More
Less

DEXAMETHASONE SODIUM PHOSPHATE Chemical Properties,Usage,Production

Originator

Decadron Phosphate,MS and D,US,1959

Uses

A pro-drug of Dexamethasone (D298800), an anti-inflammatory glucocorticoid. It was found that liposomal DXM-P inhibited both chronic inflammation and joint destruction, whereas free DXM-P failed to prevent joint destruction.

Definition

ChEBI: A steroid phosphate that is the 21-O-phospho derivative of dexamethasone.

Manufacturing Process

A solution of bis-triethylamine phosphate was prepared by slowly adding 2.36 ml of 85% phosphoric acid to 20 ml of acetonitrile containing 9.9 ml of triethylamine at 20°C. This solution was added to a stirred solution of 4.70 g of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,2-dione 21- methanesulfonate and 20 ml of acetonitrile. The mixture was heated under reflux for four hours and then evaporated under reduced pressure to a volume of 12 ml. This mixture was a concentrated solution of 9α-fluoro-11β,17α,21- trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate triethylamine salt with some inorganic phosphate.
The mixture was cooled, 25 ml of methanol added, and the cooled mixture treated with 33 ml of 1.89 N methanolic sodium methoxide solution. The precipitated inorganic phosphates were removed by suction filtration and washed thoroughly with methanol. The combined filtrates were evaporated under reduced pressure to a volume of 12 ml and treated with 30 ml of methanol. The resulting cloudy solution was clarified by filtration through diatomaceous earth. The volume of the filtrate was brought to 40 ml by the addition of methanol, and 120 ml of ether was added with stirring. The precipitated product, which was 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl1,4-pregnadiene-3,20-dione 21-phosphate sodium salt, was collected by suction filtration, and washed with acetone and then with ether. The weight of the air-dried material was 3.06 g.

brand name

Decadron (Merck); Dexacen (Cent); Dexacort (UCB); Dexair (Pharmafair); Hexadrol (Organon); Maxidex (Alcon).

Therapeutic Function

Glucocorticoid

Safety Profile

An experimental teratogen. Otherexperimental reproductive effects. Mutation data reported.When heated to decomposition it emits toxic fumes of F-and POx.

DEXAMETHASONE SODIUM PHOSPHATE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

DEXAMETHASONE SODIUM PHOSPHATE Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Shanghai Hekang Biotechnology Co., Ltd.
Tel
18939837085
Fax
2880152141(QQ)
Email
youchemicals@gmail.com
Country
China
ProdList
1830
Advantage
55
ShangHai Angti Biotechnology Co., Ltd.
Tel
13764913901
Fax
-
Email
info@angtibio.com
Country
China
ProdList
4989
Advantage
55
Hangzhou Dingyan Chem Co., LTD
Tel
0571-87157530-8002 15267169049
Fax
0571-87156470
Email
sales@dingyanchem.com
Country
China
ProdList
2190
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973186 4009686088
Email
3193328036@qq.com
Country
China
ProdList
18338
Advantage
68
Shanghai Nafu Biotechnology Co., Ltd.
Tel
021-58952328 13125124762
Fax
021-58952328
Email
sale@chemhui.com
Country
China
ProdList
482
Advantage
55
Shenzhen SUNGENING Bio-Medical Co., Ltd.
Tel
0755-28967200 13631290199
Fax
0755-28967200
Email
wxf@sungening.com
Country
China
ProdList
9577
Advantage
60
XinYao(Shenzhen) Biological Technology Co., Ltd.
Tel
0755-89880280
Fax
0755-89880280
Email
3004662104@qq.com
Country
China
ProdList
1829
Advantage
58

312-93-6, DEXAMETHASONE SODIUM PHOSPHATERelated Search:


  • (11β,16α)-9-Fluoro-11,17-dihydroxy-16-Methyl-21-(phosphonooxy)pregna-1,4-diene-3,20-dione
  • Dexamethasone Phosphate (200 mg)K0E2750.996mg/mg(dr)
  • ,21-(dihydrogenphosphate)
  • betnelanphosphate
  • [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] dihydrogen phosphate
  • [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] dihydrogen phosphate
  • [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-3-keto-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-keto-ethyl] dihydrogen phosphate
  • Dexamethasone Phosphate (200 mg)
  • dexamethasone21-orthophosphate
  • dexamethasonephosphate
  • neodecadron
  • oradexonphosphate
  • wymesone
  • 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(dihydrogen phosphate)
  • Pregna-1,4-Diene-3,20-Dione,9-Fluoro-11,17-Dihydroxy-16-Methyl-21-(Phosphonooxy)-,(11Beta,16Alpha)-
  • Dexamethasone 21-dihydrogen phosphate
  • Dexamethasone orthophosphate
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, (11β,16α)-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-(dihydrogen phosphate) (8CI)
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-phosphate (6CI)
  • 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(dihydrogen phosphate)
  • 9-Fluoro-11β,17-dihydroxy-16α-methyl-21-phosphonooxypregna-1,4-diene-3,20-dione
  • Dexamethasone 21-Phosphate D4Q: What is Dexamethasone 21-Phosphate D4 Q: What is the CAS Number of Dexamethasone 21-Phosphate D4 Q: What is the storage condition of Dexamethasone 21-Phosphate D4 Q: What are the applications of Dexamethasone 21-Phosphate D4
  • Dexamethasone Phosphate (1177000)
  • EGP 437
  • EGP437
  • EGP-437
  • Hexadrol phosphate
  • 9-fluoro-11β,17-dihydroxy-16β-methyl-3,20-dioxopregna-1,4-dien-21-yl dihydrogen phosphate (betamethasone phosphate),
  • Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, (11b,16a)
  • examethasonephosphate
  • 1, 4-PREGNADIEN-9α-FLUORO-16α-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE 21-PHOSPHATE
  • 312-93-6
  • C22H30FO8P
  • Drug Analogues
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids
  • Organics