DEXAMETHASONE SODIUM PHOSPHATE
- Product Name
- DEXAMETHASONE SODIUM PHOSPHATE
- CAS No.
- 312-93-6
- Chemical Name
- DEXAMETHASONE SODIUM PHOSPHATE
- Synonyms
- EGP437;EGP 437;EGP-437;wymesone;neodecadron;betnelanphosphate;oradexonphosphate;Hexadrol phosphate;examethasonephosphate;dexamethasonephosphate
- CBNumber
- CB0500878
- Molecular Formula
- C22H30FO8P
- Formula Weight
- 472.44
- MOL File
- 312-93-6.mol
DEXAMETHASONE SODIUM PHOSPHATE Property
- Melting point:
- 154-157°C
- Boiling point:
- 669.6±65.0 °C(Predicted)
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer, Under Inert Atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 1.67±0.10(Predicted)
- form
- Solid
- color
- White to Light Brown
- Stability:
- Hygroscopic, Moisture Sensitive
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P314Get medical advice/attention if you feel unwell.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PHR1628
- Product name
- Dexamethasone Phosphate
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 500mg
- Price
- $342
- Updated
- 2024/03/01
- Product number
- 1177000
- Product name
- Dexamethasone phosphate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 500mg
- Price
- $261.6
- Updated
- 2024/03/01
- Product number
- D298835
- Product name
- Dexamethasone Phosphate
- Packaging
- 25mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- 096162
- Product name
- Dexamethasone 21-phosphate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $742
- Updated
- 2021/12/16
- Product number
- SHG0005112
- Product name
- DEXAMETHASONE PHOSPHATE
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $750.75
- Updated
- 2021/12/16
DEXAMETHASONE SODIUM PHOSPHATE Chemical Properties,Usage,Production
Originator
Decadron Phosphate,MS and D,US,1959
Uses
A pro-drug of Dexamethasone (D298800), an anti-inflammatory glucocorticoid. It was found that liposomal DXM-P inhibited both chronic inflammation and joint destruction, whereas free DXM-P failed to prevent joint destruction.
Definition
ChEBI: A steroid phosphate that is the 21-O-phospho derivative of dexamethasone.
Manufacturing Process
A solution of bis-triethylamine phosphate was prepared by slowly adding 2.36
ml of 85% phosphoric acid to 20 ml of acetonitrile containing 9.9 ml of
triethylamine at 20°C. This solution was added to a stirred solution of 4.70 g
of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,2-dione 21-
methanesulfonate and 20 ml of acetonitrile. The mixture was heated under
reflux for four hours and then evaporated under reduced pressure to a volume
of 12 ml. This mixture was a concentrated solution of 9α-fluoro-11β,17α,21-
trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate
triethylamine salt with some inorganic phosphate.
The mixture was cooled, 25 ml of methanol added, and the cooled mixture
treated with 33 ml of 1.89 N methanolic sodium methoxide solution. The
precipitated inorganic phosphates were removed by suction filtration and
washed thoroughly with methanol. The combined filtrates were evaporated
under reduced pressure to a volume of 12 ml and treated with 30 ml of
methanol. The resulting cloudy solution was clarified by filtration through
diatomaceous earth. The volume of the filtrate was brought to 40 ml by the
addition of methanol, and 120 ml of ether was added with stirring. The
precipitated product, which was 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl1,4-pregnadiene-3,20-dione 21-phosphate sodium salt, was collected by
suction filtration, and washed with acetone and then with ether. The weight of
the air-dried material was 3.06 g.
brand name
Decadron (Merck); Dexacen (Cent); Dexacort (UCB); Dexair (Pharmafair); Hexadrol (Organon); Maxidex (Alcon).
Therapeutic Function
Glucocorticoid
Safety Profile
An experimental teratogen. Otherexperimental reproductive effects. Mutation data reported.When heated to decomposition it emits toxic fumes of F-and POx.
DEXAMETHASONE SODIUM PHOSPHATE Preparation Products And Raw materials
Raw materials
Preparation Products
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