DEXAMETHASONE SODIUM PHOSPHATE

ChemicalBook > CAS DataBase List > DEXAMETHASONE SODIUM PHOSPHATE

DEXAMETHASONE SODIUM PHOSPHATE

Product Name: DEXAMETHASONE SODIUM PHOSPHATE
CAS No.: 312-93-6
Chemical Name: DEXAMETHASONE SODIUM PHOSPHATE
Synonyms: EGP437;EGP 437;EGP-437;wymesone;neodecadron;betnelanphosphate;oradexonphosphate;Hexadrol phosphate;examethasonephosphate;dexamethasonephosphate
CBNumber: CB0500878
Molecular Formula: C22H30FO8P
Formula Weight: 472.44
MOL File: 312-93-6.mol

Less

DEXAMETHASONE SODIUM PHOSPHATE Property

Melting point:: 154-157°C
Boiling point:: 669.6±65.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer, Under Inert Atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 1.67±0.10(Predicted)
form: Solid
color: White to Light Brown
Stability:: Hygroscopic, Moisture Sensitive

Less

Safety

Hazard Codes: Xn
Risk Statements: 62
HS Code: 2937220000
Toxicity: dni-rat-ipr 3 mg/kg JOENAK 62,527,74

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR1628
Product name: Dexamethasone Phosphate
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 500mg
Price: $342
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1177000
Product name: Dexamethasone phosphate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 500mg
Price: $261.6
Updated: 2024/03/01

TRC

Product number: D298835
Product name: Dexamethasone Phosphate
Packaging: 25mg
Price: $105
Updated: 2021/12/16

Matrix Scientific

Product number: 096162
Product name: Dexamethasone 21-phosphate
Purity: 95+%
Packaging: 250mg
Price: $742
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: SHG0005112
Product name: DEXAMETHASONE PHOSPHATE
Purity: 95.00%
Packaging: 25MG
Price: $750.75
Updated: 2021/12/16

Less

DEXAMETHASONE SODIUM PHOSPHATE Chemical Properties,Usage,Production

Originator

Decadron Phosphate,MS and D,US,1959

Uses

A pro-drug of Dexamethasone (D298800), an anti-inflammatory glucocorticoid. It was found that liposomal DXM-P inhibited both chronic inflammation and joint destruction, whereas free DXM-P failed to prevent joint destruction.

Definition

ChEBI: A steroid phosphate that is the 21-O-phospho derivative of dexamethasone.

Manufacturing Process

A solution of bis-triethylamine phosphate was prepared by slowly adding 2.36 ml of 85% phosphoric acid to 20 ml of acetonitrile containing 9.9 ml of triethylamine at 20°C. This solution was added to a stirred solution of 4.70 g of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,2-dione 21- methanesulfonate and 20 ml of acetonitrile. The mixture was heated under reflux for four hours and then evaporated under reduced pressure to a volume of 12 ml. This mixture was a concentrated solution of 9α-fluoro-11β,17α,21- trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate triethylamine salt with some inorganic phosphate.
The mixture was cooled, 25 ml of methanol added, and the cooled mixture treated with 33 ml of 1.89 N methanolic sodium methoxide solution. The precipitated inorganic phosphates were removed by suction filtration and washed thoroughly with methanol. The combined filtrates were evaporated under reduced pressure to a volume of 12 ml and treated with 30 ml of methanol. The resulting cloudy solution was clarified by filtration through diatomaceous earth. The volume of the filtrate was brought to 40 ml by the addition of methanol, and 120 ml of ether was added with stirring. The precipitated product, which was 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl1,4-pregnadiene-3,20-dione 21-phosphate sodium salt, was collected by suction filtration, and washed with acetone and then with ether. The weight of the air-dried material was 3.06 g.

brand name

Decadron (Merck); Dexacen (Cent); Dexacort (UCB); Dexair (Pharmafair); Hexadrol (Organon); Maxidex (Alcon).

Therapeutic Function

Glucocorticoid

Safety Profile

An experimental teratogen. Otherexperimental reproductive effects. Mutation data reported.When heated to decomposition it emits toxic fumes of F-and POx.

DEXAMETHASONE SODIUM PHOSPHATE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

DEXAMETHASONE SODIUM PHOSPHATE Suppliers

Canada 1 China 80 Europe 2 Germany 1 India 6 United Kingdom 1 United States 4 Global 95

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Shanghai Hekang Biotechnology Co., Ltd.

Tel: 18939837085
Fax: 2880152141(QQ)
Email: youchemicals@gmail.com
Country: China
ProdList: 1832
Advantage: 55

ShangHai Angti Biotechnology Co., Ltd.

Tel: 13764913901
Fax: -
Email: info@angtibio.com
Country: China
ProdList: 5028
Advantage: 55

Hangzhou Dingyan Chem Co., LTD

Tel: 0571-87157530-8001 13616748242
Fax: 0571-87156470
Email: sales@dingyanchem.com
Country: China
ProdList: 2189
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973186 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 18338
Advantage: 68

Shanghai Nafu Biotechnology Co., Ltd.

Tel: 021-58952328 13125124762
Fax: 021-58952328
Email: sale@chemhui.com
Country: China
ProdList: 491
Advantage: 55

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-28967200 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9578
Advantage: 60

XinYao(Shenzhen) Biological Technology Co., Ltd.

Tel: 0755-89880280
Fax: 0755-89880280
Email: 3004662104@qq.com
Country: China
ProdList: 1829
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57423
Advantage: 58

TOSUN PHARM

Tel: 020-61855200 13326451905
Email: 260366801@qq.com
Country: China
ProdList: 7824
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15352
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-89586680 +86-18192503167
Fax: +86-29-88380327
Email: 1026@dideu.com
Country: China
ProdList: 7724
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30233
Advantage: 58

Hubei xin bonus chemical co. LTD

Tel: 86-13657291602
Fax: 027-59338440
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 22963
Advantage: 58

Hefei fuya biotechnology co. LTD

Tel: 18096409024
Email: sales02@foreversyn.com
Country: China
ProdList: 1907
Advantage: 58

ShangHai Anpel Co, Ltd.

Tel: 18501792038; 18501792038
Email: shanpel@anpel.com.cn
Country: China
ProdList: 9611
Advantage: 58

Shanghai Botuo Biotechnology Co., LTD

Tel: 16621358918
Fax: QQ:402135374
Email: botuopharma888@163.com
Country: China
ProdList: 9208
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10524
Advantage: 58

Hubei Xinkang Pharmaceutical Chemical Co., Ltd

Tel: 027-59308705 18871579363
Fax: 027-59308705
Email: 1248680011@qq.com
Country: China
ProdList: 9949
Advantage: 58

Hubei Baidu Chemical Co., Ltd

Tel: 027-59106051 13627137652
Fax: 027-59223020
Email: 1438180055@qq.com
Country: China
ProdList: 9880
Advantage: 58

Hubei Guangao Biotechnology Co., Ltd

Tel: 027-027-59223056 18162699093
Fax: 027-59223056
Email: 1208480011@qq.com
Country: China
ProdList: 9924
Advantage: 58

TCI (Shanghai) Chemical Trading Co., Ltd.

Tel: 021-021-61109150
Fax: 021-61105897
Email: sales@tcisct.com
Country: China
ProdList: 31121
Advantage: 58

Zhuhai Anzhe Biotechnology Co,Ltd.

Tel: 13169972583
Email: 513211116@qq.com
Country: China
ProdList: 3006
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-029-81124267 15229202216
Fax: 029-88380327
Email: 1073@dideu.com
Country: China
ProdList: 9923
Advantage: 58

Foshan Treasure Biotechnology Co., Ltd

Tel: 0757-85921206 18520245316
Email: 2329783215@qq.com
Country: China
ProdList: 12661
Advantage: 58

PureChemland Co.,Ltd.

Tel: 028-64441822 18581895003
Email: 3848291069@qq.com
Country: China
ProdList: 3337
Advantage: 58

Hubei Weideli Chemical Reagent Co.，Ltd.

Tel: 13339985473
Email: C13339985473@163.com
Country: China
ProdList: 4648
Advantage: 58

Hubei Weideli Chemical Reagent Co.，Ltd.

Tel: 027-59222918 13385289472
Email: Z13385289472@163.com
Country: China
ProdList: 4922
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Jiangsu Boquan Biotechnology Co., Ltd.

Tel: 15252131412; 15252131412
Email: 5954981@qq.com
Country: China
ProdList: 2965
Advantage: 58

Hubei Tuobang Chemical Co., Ltd.

Tel: 027-59106185 13986192185
Email: 1466039@qq.com
Country: China
ProdList: 9972
Advantage: 58

Shaanxi Cuikang Pharmaceutical Technology Co., Ltd

Tel: 18049165724 13186333400
Email: cuichengbio@163.com
Country: China
ProdList: 4023
Advantage: 58

Shanghai Saikerui Biotechnology Co. , Ltd.

Tel: 021-58000709 15900491054
Email: info@scrbio.com
Country: China
ProdList: 9740
Advantage: 58

LangFangshi Zekang Pharma Tech CO.,Itd.

Tel: 0316-2883536 19333636468
Email: 93618484@qq.com
Country: China
ProdList: 1441
Advantage: 58

Wuhan Jingkangen Biomedical Technology Co., Ltd

Tel: 13720134139 13720134139
Email: orders@jknbiochem.com
Country: China
ProdList: 5902
Advantage: 58

Wuhan Juchengyuan Biotechnology Co., Ltd

Tel: 400-027-6007 18062142210
Email: 804180422@qq.com
Country: China
ProdList: 143
Advantage: 58

Nantong Zhonghe Chemical New Materials Co., Ltd

Tel: 13003551299 13003551299
Email: 2369399482@qq.com
Country: China
ProdList: 7566
Advantage: 58

guoyungurui

Tel: 18162595016; 18162595016
Email: 3287908757@qq.com
Country: China
ProdList: 10335
Advantage: 58

Hangzhou Bingochem Co., Ltd.

Tel: 0571-8512-5372
Email: sales@bingochem.com
Country: China
ProdList: 21669
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 17301488900
Fax: 025-85560043
Email: judy.xia@synzest.com
Country: China
ProdList: 12582
Advantage: 58

Changsha Fuzhen Biotechnology Co.，LTD

Tel: 13823398779 18670069958
Email: 3062105966@qq.com
Country: China
ProdList: 3343
Advantage: 58

Olix (Shanghai) Pharmaceutical Technology Co., Ltd

Tel: 17316404525
Email: 209533805@qq.com
Country: China
ProdList: 9970
Advantage: 58

Hubei CuiRan Biotechnology Co., Ltd.

Tel: 18162791556
Email: 3152548389@qq.com
Country: China
ProdList: 4351
Advantage: 58

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 73043
Advantage: 58

Tel: 58896805
Email: 7993601name@qq.com
Country: CHINA
ProdList: 15620
Advantage: 58

Tel: 18153089275
Email: 3032079623@qq.com
Country: China
ProdList: 22695
Advantage: 58

Shanghai Weiyite Biotechnology Co., Ltd

Tel: 15317051735
Email: josie@wytsci.com
Country: China
ProdList: 8705
Advantage: 58

312-93-6, DEXAMETHASONE SODIUM PHOSPHATERelated Search:

Desoximetasone Dexamethasone 21-phosphate disodium salt Dexamethasone palmitate Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-[(3-sulfobenzoyl)oxy]-, monosodium salt, (11beta,16alpha)- Dexamethasone dipropionate 9-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 17-valerate Dexamethasone 9,11-epoxide 1,2-Dihydro DesoxyMetasone Dexamethasone Impurity I Dexamethasone EP Impurity E DexaMethasone β-D-Glucuronide SodiuM Salt Dexamethasone-d5 Dexamethasone 21-Propionate PSXDNQUHAFMVPT-NWQAGDSVSA-N Dexamethasone-17,20 21-Aldehyde dexamethasone 21-pivalate dexamethasone 21-(3-phenylpropionate) Dexamethasone 17-propionate

(11β,16α)-9-Fluoro-11,17-dihydroxy-16-Methyl-21-(phosphonooxy)pregna-1,4-diene-3,20-dione

Dexamethasone Phosphate (200 mg)K0E2750.996mg/mg(dr)

,21-(dihydrogenphosphate)

betnelanphosphate

[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] dihydrogen phosphate

[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] dihydrogen phosphate

[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-3-keto-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-keto-ethyl] dihydrogen phosphate

Dexamethasone Phosphate (200 mg)

dexamethasone21-orthophosphate

dexamethasonephosphate

neodecadron

oradexonphosphate

wymesone

9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(dihydrogen phosphate)

Pregna-1,4-Diene-3,20-Dione,9-Fluoro-11,17-Dihydroxy-16-Methyl-21-(Phosphonooxy)-,(11Beta,16Alpha)-

Dexamethasone 21-dihydrogen phosphate

Dexamethasone orthophosphate

Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, (11β,16α)-

Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-(dihydrogen phosphate) (8CI)

Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-phosphate (6CI)

9-Fluoro-11β,17-dihydroxy-16α-methyl-21-phosphonooxypregna-1,4-diene-3,20-dione

Dexamethasone 21-Phosphate D4Q: What is Dexamethasone 21-Phosphate D4 Q: What is the CAS Number of Dexamethasone 21-Phosphate D4 Q: What is the storage condition of Dexamethasone 21-Phosphate D4 Q: What are the applications of Dexamethasone 21-Phosphate D4

Dexamethasone Phosphate (1177000)

EGP 437

EGP437

EGP-437

Hexadrol phosphate

9-fluoro-11β,17-dihydroxy-16β-methyl-3,20-dioxopregna-1,4-dien-21-yl dihydrogen phosphate (betamethasone phosphate),

Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, (11b,16a)

examethasonephosphate

1, 4-PREGNADIEN-9α-FLUORO-16α-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE 21-PHOSPHATE

9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(dihydrogen phosphate)

Dexamethasone Hydrogen Phosphate

312-93-6

C22H30FO8P

Drug Analogues

Intermediates & Fine Chemicals

Pharmaceuticals

Steroids

Organics