DEXAMETHASONE SODIUM PHOSPHATE

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DEXAMETHASONE SODIUM PHOSPHATE

Product Name: DEXAMETHASONE SODIUM PHOSPHATE
CAS No.: 312-93-6
Chemical Name: DEXAMETHASONE SODIUM PHOSPHATE
Synonyms: EGP437;EGP 437;EGP-437;wymesone;neodecadron;betnelanphosphate;oradexonphosphate;Hexadrol phosphate;examethasonephosphate;dexamethasonephosphate
CBNumber: CB0500878
Molecular Formula: C22H30FO8P
Formula Weight: 472.44
MOL File: 312-93-6.mol

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DEXAMETHASONE SODIUM PHOSPHATE Property

Melting point:: 154-157°C
Boiling point:: 669.6±65.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer, Under Inert Atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 1.67±0.10(Predicted)
form: Solid
color: White to Light Brown
Stability:: Hygroscopic, Moisture Sensitive

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Safety

Hazard Codes: Xn
Risk Statements: 62
HS Code: 2937220000
Toxicity: dni-rat-ipr 3 mg/kg JOENAK 62,527,74

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR1628
Product name: Dexamethasone Phosphate
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 500mg
Price: $342
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1177000
Product name: Dexamethasone phosphate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 500mg
Price: $261.6
Updated: 2024/03/01

TRC

Product number: D298835
Product name: Dexamethasone Phosphate
Packaging: 25mg
Price: $105
Updated: 2021/12/16

Matrix Scientific

Product number: 096162
Product name: Dexamethasone 21-phosphate
Purity: 95+%
Packaging: 250mg
Price: $742
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: SHG0005112
Product name: DEXAMETHASONE PHOSPHATE
Purity: 95.00%
Packaging: 25MG
Price: $750.75
Updated: 2021/12/16

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DEXAMETHASONE SODIUM PHOSPHATE Chemical Properties,Usage,Production

Originator

Decadron Phosphate,MS and D,US,1959

Uses

A pro-drug of Dexamethasone (D298800), an anti-inflammatory glucocorticoid. It was found that liposomal DXM-P inhibited both chronic inflammation and joint destruction, whereas free DXM-P failed to prevent joint destruction.

Definition

ChEBI: A steroid phosphate that is the 21-O-phospho derivative of dexamethasone.

Manufacturing Process

A solution of bis-triethylamine phosphate was prepared by slowly adding 2.36 ml of 85% phosphoric acid to 20 ml of acetonitrile containing 9.9 ml of triethylamine at 20°C. This solution was added to a stirred solution of 4.70 g of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,2-dione 21- methanesulfonate and 20 ml of acetonitrile. The mixture was heated under reflux for four hours and then evaporated under reduced pressure to a volume of 12 ml. This mixture was a concentrated solution of 9α-fluoro-11β,17α,21- trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate triethylamine salt with some inorganic phosphate.
The mixture was cooled, 25 ml of methanol added, and the cooled mixture treated with 33 ml of 1.89 N methanolic sodium methoxide solution. The precipitated inorganic phosphates were removed by suction filtration and washed thoroughly with methanol. The combined filtrates were evaporated under reduced pressure to a volume of 12 ml and treated with 30 ml of methanol. The resulting cloudy solution was clarified by filtration through diatomaceous earth. The volume of the filtrate was brought to 40 ml by the addition of methanol, and 120 ml of ether was added with stirring. The precipitated product, which was 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl1,4-pregnadiene-3,20-dione 21-phosphate sodium salt, was collected by suction filtration, and washed with acetone and then with ether. The weight of the air-dried material was 3.06 g.

brand name

Decadron (Merck); Dexacen (Cent); Dexacort (UCB); Dexair (Pharmafair); Hexadrol (Organon); Maxidex (Alcon).

Therapeutic Function

Glucocorticoid

Safety Profile

An experimental teratogen. Otherexperimental reproductive effects. Mutation data reported.When heated to decomposition it emits toxic fumes of F-and POx.

DEXAMETHASONE SODIUM PHOSPHATE Preparation Products And Raw materials

Raw materials

Preparation Products

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312-93-6, DEXAMETHASONE SODIUM PHOSPHATERelated Search:

Desoximetasone Dexamethasone 21-phosphate disodium salt Dexamethasone palmitate Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-[(3-sulfobenzoyl)oxy]-, monosodium salt, (11beta,16alpha)- Dexamethasone dipropionate 9-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 17-valerate Dexamethasone 9,11-epoxide 1,2-Dihydro DesoxyMetasone Dexamethasone Impurity I Dexamethasone EP Impurity E DexaMethasone β-D-Glucuronide SodiuM Salt Dexamethasone-d5 Dexamethasone 21-Propionate PSXDNQUHAFMVPT-NWQAGDSVSA-N Dexamethasone-17,20 21-Aldehyde dexamethasone 21-pivalate dexamethasone 21-(3-phenylpropionate) Dexamethasone 17-propionate

(11β,16α)-9-Fluoro-11,17-dihydroxy-16-Methyl-21-(phosphonooxy)pregna-1,4-diene-3,20-dione

Dexamethasone Phosphate (200 mg)K0E2750.996mg/mg(dr)

,21-(dihydrogenphosphate)

betnelanphosphate

[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] dihydrogen phosphate

[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] dihydrogen phosphate

[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-3-keto-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-keto-ethyl] dihydrogen phosphate

Dexamethasone Phosphate (200 mg)

dexamethasone21-orthophosphate

dexamethasonephosphate

neodecadron

oradexonphosphate

wymesone

9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(dihydrogen phosphate)

Pregna-1,4-Diene-3,20-Dione,9-Fluoro-11,17-Dihydroxy-16-Methyl-21-(Phosphonooxy)-,(11Beta,16Alpha)-

Dexamethasone 21-dihydrogen phosphate

Dexamethasone orthophosphate

Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, (11β,16α)-

Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-(dihydrogen phosphate) (8CI)

Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-phosphate (6CI)

9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(dihydrogen phosphate)

9-Fluoro-11β,17-dihydroxy-16α-methyl-21-phosphonooxypregna-1,4-diene-3,20-dione

Dexamethasone 21-Phosphate D4Q: What is Dexamethasone 21-Phosphate D4 Q: What is the CAS Number of Dexamethasone 21-Phosphate D4 Q: What is the storage condition of Dexamethasone 21-Phosphate D4 Q: What are the applications of Dexamethasone 21-Phosphate D4

Dexamethasone Phosphate (1177000)

EGP 437

EGP437

EGP-437

Hexadrol phosphate

9-fluoro-11β,17-dihydroxy-16β-methyl-3,20-dioxopregna-1,4-dien-21-yl dihydrogen phosphate (betamethasone phosphate),

Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, (11b,16a)

examethasonephosphate

1, 4-PREGNADIEN-9α-FLUORO-16α-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE 21-PHOSPHATE

312-93-6

C22H30FO8P

Drug Analogues

Intermediates & Fine Chemicals

Pharmaceuticals

Steroids

Organics