Overview Information Effectiveness Side Effects
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Yohimbine

Overview Information Effectiveness Side Effects
Product Name
Yohimbine
CAS No.
146-48-5
Chemical Name
Yohimbine
Synonyms
Yocon;Yohimex;Corynine;Aphrosol;Yohimbin;RAUBASIN;Aphrodine;yohimbine;Aphrodyne;Quebrachin
CBNumber
CB4129677
Molecular Formula
C21H26N2O3
Formula Weight
354.44
MOL File
146-48-5.mol
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Yohimbine Property

Melting point:
231-233 °C(lit.)
alpha 
D20 +50.9 to +62.2° (ethanol); D20 +108° (pyridine); 20546 +129° (c = 0.5 in pyridine)
Boiling point:
487.66°C (rough estimate)
Density 
1.1640 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
Store at RT
pka
14.39±0.40(Predicted)
CAS DataBase Reference
146-48-5(CAS DataBase Reference)
NIST Chemistry Reference
Yohimbine(146-48-5)
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25-39
Safety Statements 
27-36/37/39-45
RIDADR 
1544
RTECS 
ZG1000000
HazardClass 
6.1(a)
PackingGroup 
II
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Hazard and Precautionary Statements (GHS)

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Yohimbine Chemical Properties,Usage,Production

Overview Information

Yohimbe is the name of an evergreen tree found in parts of central and western Africa. The bark of yohimbe contains a chemical called yohimbine, which is used to make medicine. Yohimbine hydrochloride (Aphrodyne, Yocon) is a form of yohimbine that is a prescription drug in the US.
Yohimbe supplements often list yohimbe bark extract or yohimbine as the active ingredient. However, some of these products might not provide accurate information about the amount of yohimbine in the supplement. Also, some yohimbe supplements list yohimbine hydrochloride as an active ingredient. Yohimbe products containing man-made yohimbine hydrochloride as an ingredient are not legal to sell as a dietary supplement in the US.


Yohimbe is taken by mouth arouse sexual excitement, for erectile dysfunction (ED), sexual problems caused by medications for depression called selective-serotonin reuptake inhibitors (SSRIs), and general sexual problems in both men and women. It is also used for athletic performance, weight loss, exhaustion, chest pain, high blood pressure, low blood pressure that occurs when standing up, diabetic nerve pain, and for depression along with certain other medications.

Effectiveness

Anxiety. There is mixed evidence about the effectiveness of yohimbine, the active ingredient in yohimbe, for treating anxiety related to phobias. Some research suggests that it does not improve anxiety when combined with therapy. However, other research suggests that it reduces fear related to certain phobias.
Depression. Early research suggests that taking yohimbine, the active ingredient of yohimbe, daily for 10 days does not improve depression symptoms.
Erectile dysfunction (ED). There is evidence that yohimbine, the active ingredient of yohimbe, can be helpful for ED. Some herbalists suggest that the yohimbe bark actually works better than the yohimbine ingredient alone. However, so far yohimbe bark has not been evaluated in research studies.
Exercise performance. Early research suggests that taking yohimbine, the active ingredient in yohimbe, daily for 21 days does not improve exercise performance or build muscle mass in soccer players.
Head rush (orthostatic hypotension). Early research suggests that taking a single dose of yohimbine, the active ingredient in yohimbe, increases blood pressure in people with a head rush due to low blood pressure. However, other early research suggests that it does not improve blood pressure.
Sexual problems caused by selective-serotonin reuptake inhibitors (SSRIs). There is evidence from many studies that yohimbine, the active ingredient of yohimbe, can improve sexual problems associated with this class of medications used for depression. However, this benefit has not been described specifically for the yohimbe bark.
Dry mouth. Early research suggests that taking yohimbine, the active ingredient in yohimbe, improves symptoms of dry mouth in people taking antidepressants. The effect of the yohimbe bark on dry mouth is not clear.

Side Effects

Yohimbe, taken by mouth, is POSSIBLY UNSAFE. Yohimbe has been linked to reports of severe side effects including irregular or rapid heart beat, kidney failure, seizure, heart attack, and others.
The primary active ingredient in yohimbe is a drug called yohimbine. This is considered a prescription drug in North America. This drug can be safely used short-term when monitored by a health professional.
However, it is not appropriate for unsupervised use due to potentially serious side effects that it can cause.
Children should not take yohimbe. It is POSSIBLY UNSAFE for children because children appear to be extra sensitive to the harmful effects of yohimbe.
When taken by mouth in typical doses, yohimbe and the ingredient yohimbine can cause stomach upset, excitation, tremor, sleep problems, anxiety or agitation, high blood pressure, a racing heartbeat, dizziness, stomach problems, drooling, sinus pain, irritability, headache, frequent urination, bloating, rash, nausea, and vomiting.
Taking high doses can also cause other severe problems, including difficulty breathing, paralysis, very low blood pressure, heart problems, and death. After taking a one-day dose of yohimbine, one person reported an allergic reaction involving fever; chills; listlessness; itchy, scaly skin; progressive kidney failure; and symptoms that looked like the auto-immune disease called lupus.

Chemical Properties

Glistening, needle-like alkaloid, soluble in alcohol and ether, very slightly soluble in water.

Uses

sexual dysfunction

Uses

Yohimbine occurs in Corinanthe johimbeK. and Rubiaceae trees. It is also foundin the roots of Rauwolfia serpentina L.and Apocyanaceae. Its derivatives areused therapeutically as adrenergic blockingagents.

Definition

ChEBI: An indole alkaloid with alpha2-adrenoceptor antagonist activity. It is produced by Corynanthe johimbe and Rauwolfia serpentina.

General Description

Yohimbine (Yocon)is a competitive and selective 2-blocker. The compound isan indolealkylamine alkaloid and is found in the bark of thetree Pausinystalia yohimbe and in Rauwolfia root.

Health Hazard

Pharmacologically, yohimbine is an adrenergic blocking agent. It exhibits hypotensive and cardiostimulant activities. Poisoningfrom excessive doses may become severe,causing convulsions and respiratory failure
LD50 value, intraperitoneal (mice): 16 mg/kg
LD50 value, oral (mice): 37 mg/kg.

Biological Activity

α 2 -adrenoceptor antagonist (pK i values are 8.52, 8.00 and 9.17 for human a 2A , a 2B and a 2C receptors respectively).

Clinical Use

Yohimbine increases heart rate and blood pressure as aresult of its blockade of 2-receptors in the CNS. It has beenused experimentally to treat male erectile impotence.

Purification Methods

Crystallise the alkaloid from EtOH, and dry it in a vacuum to remove EtOH of crystallisation. [Van Tamelen et al. J Am Chem Soc 91 7315 1969, Stork

Yohimbine Preparation Products And Raw materials

Raw materials

Preparation Products

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Yohimbine Suppliers

Nanjing Yuding Pharmaceutical Technology Co., Ltd
Tel
Email
2679876941@qq.com
Country
China
ProdList
15
Advantage
58
Zhejiang Zunhai Pharmaceutical Technology Co. LTD
Tel
177-6693891-
Fax
17776693891
Email
2061448612@qq.com
Country
China
ProdList
20
Advantage
58
Zhejiang Saiying Medical Technology Co. LTD
Tel
1782-6401654-
Email
3509199020@qq.com
Country
China
ProdList
15
Advantage
58
Chengdu mingnijitai Pharmaceutical Co., Ltd
Tel
156-2687-9035
Email
2471283371@qq.com
Country
China
ProdList
75
Advantage
58
Zhejiang chaohui medicine technology co., ltd
Tel
021-34514716-
Email
3451471607@qq.com
Country
China
ProdList
23
Advantage
58
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15880
Advantage
69
BeiJing Hwrk Chemicals Limted
Tel
0757-86311057-
Fax
0757-86311057
Email
kennyrong@hwrkchemical.com
Country
China
ProdList
18708
Advantage
55
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005;021-58099637-8009
Fax
021-58099609
Email
bin.wu@shlschem.com;sales@shlschem.com
Country
China
ProdList
9830
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202- ;021-54308259-
Fax
+86-21-64545202
Email
info@hanhonggroup.com;info@hanhonggroup.com
Country
China
ProdList
43258
Advantage
64
Chengdu XiYa Chemical Technology Co., Ltd.
Tel
;
Fax
0539-6365991
Email
sale@xiyashiji.com;3007716753@qq.com
Country
China
ProdList
10576
Advantage
57
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View Lastest Price from Yohimbine manufacturers

Wuhan Monad Medicine Tech Co.,LTD
Product
Yohimbine 146-48-5
Price
US $50.00/KG
Min. Order
1Kg/Bag
Purity
99.99%
Supply Ability
20 tons/month
Release date
2020-12-24
hdzhl biotechnology co., ltd
Product
Yohimbine 146-48-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 MT
Release date
2019-12-04
career henan chemical co
Product
Yohimbine 146-48-5
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-04

146-48-5, YohimbineRelated Search:


  • yohimbine
  • YOHIMBINE, C-
  • 17alpha-Hydroxyyohimban-16alpha-carboxylic acid
  • 17-alpha-hydroxy-yohimban-16-alpha-carboxylicacimethylester
  • 17-Hydroxyyohimban-16-carboxylic acid methyl ester
  • 17-hydroxyyohimban-16-carboxylicacidmethylester
  • Aphrodine
  • Aphrosol
  • Benz[g]indolo[2,3-a]quinolizine, yohimban-16-carboxylic acid deriv.
  • Corynine
  • Methyl 17-hydroxyyohimban-16-carboxylate
  • Quebrachin
  • Quebrachine
  • Yohimban-16alpha-carboxylic acid, 17alpha-hydroxy-, methyl ester
  • Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16alpha,17alpha)-
  • Yohimbic acid methyl ester
  • yohimbicacidmethylester
  • Yohimbin
  • D-YOHIMBINE
  • 17alpha-hydroxy-yohimban-16alpha-carboxylic acid methyl ester
  • ALPHA-YOHIMBIN
  • RAUBASIN
  • 17alpha-Hydroxyyohimban-16-carboxylic acid methyl ester
  • (+)-17α-Hydroxyyohimban-16α-carboxylic acid methyl
  • (16alpha,17alpha)-17-Hydroxy-yohimban-16-carboxylic acid methyl ester
  • 17-Hydroxy-yohimbane-16-carboxylic acid methyl ester
  • 2-Hydroxy-1,2,3,4,4A,5,7,8,13,13B,14,14A-dodecahydro-indolo[2',3':3,4]pyrido[1,2-B]isoquinoline-1-carboxylic acid methyl ester
  • Inchi=1/C21H26N2o3/C1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/H2-5,12,15,17-19,22,24H,6-11H2,1H3/T12,15,17,18-,19+/m0/s
  • Methyl (16alpha,17alpha)-17-hydroxyyohimban-16-carboxylate
  • YOHIMBINE(P)
  • Yohimbine hydrochloride,17-Hydroxyyohimban-16-carboxylic acid methyl ester hydrochloride
  • Aphrodyne
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  • YohiMban-16-carboxylicacid, 17-hydroxy-, Methyl ester, (16a,17a)-
  • 146-48-5
  • Adrenoceptor
  • Plant extracts
  • API