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Yohimbine

Product Name
Yohimbine
CAS No.
146-48-5
Chemical Name
Yohimbine
Synonyms
Yocon;Yohimex;RAUBASIN;Aphrosol;Corynine;Yohimbin;Aphrodine;yohimbine;Aphrodyne;Quebrachin
CBNumber
CB4129677
Molecular Formula
C21H26N2O3
Formula Weight
354.45
MOL File
146-48-5.mol
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Yohimbine Property

Melting point:
231-233 °C(lit.)
alpha 
D20 +50.9 to +62.2° (ethanol); D20 +108° (pyridine); 20546 +129° (c = 0.5 in pyridine)
Boiling point:
487.66°C (rough estimate)
Density 
1.1640 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
Store at RT
CAS DataBase Reference
146-48-5(CAS DataBase Reference)
NIST Chemistry Reference
Yohimbine(146-48-5)
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25-39
Safety Statements 
27-36/37/39-45
RIDADR 
1544
RTECS 
ZG1000000
HazardClass 
6.1(a)
PackingGroup 
II
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Hazard and Precautionary Statements (GHS)

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Yohimbine Chemical Properties,Usage,Production

Chemical Properties

Glistening, needle-like alkaloid, soluble in alcohol and ether, very slightly soluble in water.

Uses

sexual dysfunction

Uses

Yohimbine occurs in Corinanthe johimbeK. and Rubiaceae trees. It is also foundin the roots of Rauwolfia serpentina L.and Apocyanaceae. Its derivatives areused therapeutically as adrenergic blockingagents.

Definition

ChEBI: An indole alkaloid with alpha2-adrenoceptor antagonist activity. It is produced by Corynanthe johimbe and Rauwolfia serpentina.

General Description

Yohimbine (Yocon)is a competitive and selective 2-blocker. The compound isan indolealkylamine alkaloid and is found in the bark of thetree Pausinystalia yohimbe and in Rauwolfia root.

Health Hazard

Pharmacologically, yohimbine is an adrenergic blocking agent. It exhibits hypotensive and cardiostimulant activities. Poisoningfrom excessive doses may become severe,causing convulsions and respiratory failure
LD50 value, intraperitoneal (mice): 16 mg/kg
LD50 value, oral (mice): 37 mg/kg.

Biological Activity

α 2 -adrenoceptor antagonist (pK i values are 8.52, 8.00 and 9.17 for human a 2A , a 2B and a 2C receptors respectively).

Clinical Use

Yohimbine increases heart rate and blood pressure as aresult of its blockade of 2-receptors in the CNS. It has beenused experimentally to treat male erectile impotence.

Purification Methods

Crystallise the alkaloid from EtOH, and dry it in a vacuum to remove EtOH of crystallisation. [Van Tamelen et al. J Am Chem Soc 91 7315 1969, Stork

Yohimbine Preparation Products And Raw materials

Raw materials

Preparation Products

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Yohimbine Suppliers

Shaanxi Pioneer Biotech Co., Ltd.
Tel
029-8438-5017 18892083351
Fax
029-8438-5017
Email
sales3@pioneerbiotech.com
Country
China
ProdList
2845
Advantage
55
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
86-21-50328103 * 801、802、803、804 Mobile:18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15881
Advantage
69
Arden pharmaceutical &chemical Co., Ltd
Tel
+86-(0)533-3595900 13793319233
Fax
+86-(0)533-3595900
Email
info@chems.com.cn
Country
China
ProdList
669
Advantage
61
BeiJing Hwrk Chemicals Limted
Tel
4006990298;010-57411839;0757-86311057;021-51691807
Fax
010-87653215;0757-86311057;021-55236763
Email
sales@hwrkchemical.com
Country
China
ProdList
14684
Advantage
55
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099637,58099652,58099650,58099609 To 8009,8068; 13585536065,QQ:975986869
Fax
0086-21-33191781
Email
sales@shlschem.com; bin.wu@shlschem.com;xianjun.hong@shlschem.com
Country
China
ProdList
9828
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202,021-54308259
Fax
+86-21-64545202
Email
info@hanhonggroup.com
Country
China
ProdList
43260
Advantage
64
China Langchem Inc.
Tel
0086-21-58956006,021-38701807;021-58950017
Fax
0086-21-58956100
Email
sales@langchem.com
Country
China
ProdList
7836
Advantage
57
Hubei YuanCheng Pharmaceutical Co., Ltd.
Tel
18062666904
Fax
QQ:2355880546
Email
wyy01@ycphar.com
Country
China
ProdList
670
Advantage
65
ZhengZhou HuaWen Chemical Co.Ltd
Tel
0370-2769949;0370-2070108;0370-2059268;0370-2267897;0370-2785118,18137146004,19913227059,18338758121
Fax
0370-2267897
Email
huawenchem@163.com
Country
China
ProdList
3008
Advantage
55
Jinan Haohua Industry Co., Ltd
Tel
0531-58773082 ;58773060
Fax
0531-58773099
Email
sales@jnhaohua.com
Country
China
ProdList
5585
Advantage
58
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View Lastest Price from Yohimbine manufacturers

career henan chemical co
Product
Yohimbine 146-48-5
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-04

146-48-5, YohimbineRelated Search:


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