Rauwolscine hydrochloride
- Product Name
- Rauwolscine hydrochloride
- CAS No.
- 6211-32-1
- Chemical Name
- Rauwolscine hydrochloride
- Synonyms
- RAUWOLSCINE;RAUWOLSCINE HCL;Nsc407307;ISOYOHIMBINE;MESOYOHIMBINE;ALPHA-YOHIMBINE;ALPHA-YOHIMBINE HCL;YOHIMBINE HCL, ALPHA-;RAUWOLSCINE HYDROCHLORIDE;α-Yohimbine hydrochloride
- CBNumber
- CB1684795
- Molecular Formula
- C21H27ClN2O3
- Formula Weight
- 390.9
- MOL File
- 6211-32-1.mol
Rauwolscine hydrochloride Property
- Melting point:
- 270-280°C
- storage temp.
- Store at RT
- solubility
- H2O: soluble
- form
- solid
- color
- white
- Sensitive
- Light Sensitive
Safety
- Hazard Codes
- T
- Risk Statements
- 23/24/25
- Safety Statements
- 22-36/37/39-45
- RIDADR
- UN 1544 6.1/PG 2
- WGK Germany
- 3
- RTECS
- ZG1035000
- HazardClass
- 6.1
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H300Fatal if swallowed
H310Fatal in contact with skin
H330Fatal if inhaled
- Precautionary statements
-
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P320Specific treatment is urgent (see … on this label).
P330Rinse mouth.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- J63198
- Product name
- Rauwolscine hydrochloride, 99%
- Packaging
- 100mg
- Price
- $138.65
- Updated
- 2024/03/01
- Product number
- 15596
- Product name
- Rauwolscine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 15596
- Product name
- Rauwolscine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 15596
- Product name
- Rauwolscine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $151
- Updated
- 2024/03/01
- Product number
- 0891
- Product name
- Rauwolscinehydrochloride
- Purity
- ≥95%(HPLC)
- Packaging
- 100
- Price
- $85
- Updated
- 2021/12/16
Rauwolscine hydrochloride Chemical Properties,Usage,Production
Description
This alkaloid is isolated as the oxalate from the leaf extract of Rauwolfia canescens L. from which the free base may be obtained as colourless needles which are laevorotatory with [α]30D - 40° (EtOH). The alkaloid forms crystalline salts: the hydrochloride, m.p. 27S-2S00C (dec.); [α]30D + 74° (H20); nitrate, m.p. 257-SoC (dec.); oxalate, m.p. 245-6°C and the picrate, m.p. 20SoC. Two active hydrogens are present and the alkaloid furnishes a monoacetyl derivative, m.p. 2l6-SoC (dec.). Treatment with concentrated ammonia solution at room temperature converts the base into rauwolscinic acid, C2oH2403N2.H20, m.p. 262-4°C (dec.); [α]23D + l36.So (H20) which yields a crystalline hydrochloride, m.p. 255.5-257.5°C (dec.) and on esterification with MeOH reverts to the original alkaloid. On distillation with Zn dust, rauwolscine yields harman, 2-methylindole (skatole) and isoquinoline.
Chakravarti has shown that the alkaloid is a cardiovascular depressant, shows hypotensive activity and is relatively highly toxic.
Uses
Rauwolscine is a natural alkaloid that acts as a selective and reversible α2-adrenergic receptor antagonist (Ki = 12 nM). It is a stereoisomer of yohimbine, which potently antagonizes both α1- and α2-adrenergic receptors. Rauwolscine also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki = 14.3 nM) and as a weak partial agonist at 5-HT1A (IC50 = 1.3 μM).The α2-adrenergic receptor has diverse physiological functions and antagonists like rauwolscine have numerous applications, including the modulation of mood and behavior.
Uses
Standard alpha-2 adrenergic antagonist
Biological Activity
Rauwolscine hydrochloride is a standard α2-adrenergic antagonist (Ki values are 3.5, 4.6, and 0.6 nM at cloned human α2A, α2B, and α2C-adrenoceptors respectively). Partial agonist at 5-HT1A receptors. Also available as part of the α2-Adrenoceptor Tocriset? .
References
Mukherjee., J. Ind. Chern. Soc., 18, 33, 485 (1941)
Mukherjee., ibid, 20, 11 (1943)
Mukherjee., ibid, 23, 6 (1946)
Pharmacology:
Chakravarti., Sci. Cult., (Calcutta), 7, 45S (1942)
Rauwolscine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Rauwolscine hydrochloride manufacturers
- Product
- Rauwolscine hydrochloride 6211-32-1
- Price
- US $420.00-320.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 9000kg/per week
- Release date
- 2022-02-12
- Product
- RAUWOLSCINE HYDROCHLORIDE 6211-32-1
- Price
- US $10.50/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2021-07-08
- Product
- Rauwolscine Hydrochloride,Rauwolscine 6211-32-1
- Price
- US $0.00/Kg/Bag
- Min. Order
- 100g/Bag
- Purity
- 99%
- Supply Ability
- 1-10 tons
- Release date
- 2021-10-27