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Rauwolscine hydrochloride

Product Name
Rauwolscine hydrochloride
CAS No.
6211-32-1
Chemical Name
Rauwolscine hydrochloride
Synonyms
RAUWOLSCINE;RAUWOLSCINE HCL;Nsc407307;ISOYOHIMBINE;MESOYOHIMBINE;ALPHA-YOHIMBINE;ALPHA-YOHIMBINE HCL;YOHIMBINE HCL, ALPHA-;RAUWOLSCINE HYDROCHLORIDE;α-Yohimbine hydrochloride
CBNumber
CB1684795
Molecular Formula
C21H27ClN2O3
Formula Weight
390.9
MOL File
6211-32-1.mol
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Rauwolscine hydrochloride Property

Melting point:
270-280°C
storage temp. 
Store at RT
solubility 
H2O: soluble
form 
solid
color 
white
Sensitive 
Light Sensitive
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
22-36/37/39-45
RIDADR 
UN 1544 6.1/PG 2
WGK Germany 
3
RTECS 
ZG1035000
HazardClass 
6.1
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H300Fatal if swallowed

H310Fatal in contact with skin

H330Fatal if inhaled

Precautionary statements

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P320Specific treatment is urgent (see … on this label).

P330Rinse mouth.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J63198
Product name
Rauwolscine hydrochloride, 99%
Packaging
100mg
Price
$138.65
Updated
2024/03/01
Cayman Chemical
Product number
15596
Product name
Rauwolscine (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
15596
Product name
Rauwolscine (hydrochloride)
Purity
≥98%
Packaging
100mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
15596
Product name
Rauwolscine (hydrochloride)
Purity
≥98%
Packaging
250mg
Price
$151
Updated
2024/03/01
Tocris
Product number
0891
Product name
Rauwolscinehydrochloride
Purity
≥95%(HPLC)
Packaging
100
Price
$85
Updated
2021/12/16
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Rauwolscine hydrochloride Chemical Properties,Usage,Production

Description

This alkaloid is isolated as the oxalate from the leaf extract of Rauwolfia canescens L. from which the free base may be obtained as colourless needles which are laevorotatory with [α]30D - 40° (EtOH). The alkaloid forms crystalline salts: the hydrochloride, m.p. 27S-2S00C (dec.); [α]30D + 74° (H20); nitrate, m.p. 257-SoC (dec.); oxalate, m.p. 245-6°C and the picrate, m.p. 20SoC. Two active hydrogens are present and the alkaloid furnishes a monoacetyl derivative, m.p. 2l6-SoC (dec.). Treatment with concentrated ammonia solution at room temperature converts the base into rauwolscinic acid, C2oH2403N2.H20, m.p. 262-4°C (dec.); [α]23D + l36.So (H20) which yields a crystalline hydrochloride, m.p. 255.5-257.5°C (dec.) and on esterification with MeOH reverts to the original alkaloid. On distillation with Zn dust, rauwolscine yields harman, 2-methylindole (skatole) and isoquinoline.
Chakravarti has shown that the alkaloid is a cardiovascular depressant, shows hypotensive activity and is relatively highly toxic.

Uses

Rauwolscine is a natural alkaloid that acts as a selective and reversible α2-adrenergic receptor antagonist (Ki = 12 nM). It is a stereoisomer of yohimbine, which potently antagonizes both α1- and α2-adrenergic receptors. Rauwolscine also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki = 14.3 nM) and as a weak partial agonist at 5-HT1A (IC50 = 1.3 μM).The α2-adrenergic receptor has diverse physiological functions and antagonists like rauwolscine have numerous applications, including the modulation of mood and behavior.

Uses

Standard alpha-2 adrenergic antagonist

Biological Activity

Rauwolscine hydrochloride is a standard α2-adrenergic antagonist (Ki values are 3.5, 4.6, and 0.6 nM at cloned human α2A, α2B, and α2C-adrenoceptors respectively). Partial agonist at 5-HT1A receptors. Also available as part of the α2-Adrenoceptor Tocriset? .

References

Mukherjee., J. Ind. Chern. Soc., 18, 33, 485 (1941)
Mukherjee., ibid, 20, 11 (1943)
Mukherjee., ibid, 23, 6 (1946)
Pharmacology:
Chakravarti., Sci. Cult., (Calcutta), 7, 45S (1942)

Rauwolscine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Rauwolscine hydrochloride manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
RAUWOLSCINE HYDROCHLORIDE 6211-32-1
Price
US $10.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-08
Henan Weian Pharmaceutical Co. LTD
Product
Rauwolscine Hydrochloride,Rauwolscine 6211-32-1
Price
US $0.00/Kg/Bag
Min. Order
100g/Bag
Purity
99%
Supply Ability
1-10 tons
Release date
2021-10-27
Henan Weian Pharmaceutical Co. LTD
Product
Rauwolscine hydrochloride 6211-32-1
Price
US $0.00/Kg/Bag
Min. Order
100g/Bag
Purity
99%
Supply Ability
1-10 tons
Release date
2021-10-28

6211-32-1, Rauwolscine hydrochlorideRelated Search:

4-BUTYLPIPERIDINE Methyl cyclohexanecarboxylate Methyl 7-aminoheptanoate 3-PIPERIDIN-3-YL-PROPAN-1-OL 4-N-PROPYLPIPERIDINE (1-Methyl-piperidin-4-yl)-acetaldehyde 1-METHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE METHYL 3-HYDROXYDECANOATE Methyl 4-piperidineacetate Rauwolscine hydrochloride METHYL 3-HYDROXYNONANOATE 2-HYDROXYCYCLOHEXANECARBOXYLIC ACID 2-Methylindole-3-ethylamine YOHIMBINE HCL(P) Raubasine Yohimbine hydrochloride Yohimbine 5-(DIMETHYLAMINO)-PENTANOIC ACID HYDROCHLORIDE

  • RAUWOLSCINE HYDROCHLORIDE (A-YOHIMBINE) A2 AD
  • α-Yohimbine hydrochloride, 17α-Hydroxy-20α-yohimban-16 β-carboxylic acid methyl ester hydrochloride
  • Corynanthidine hydrochloride
  • Isoyohimbine hydrochloride
  • Rauwolscine dot hydrochloride
  • ALPHA YOHIMBINE HCL 90% (Rauwolscine HCL 90%)
  • YohiMban-16-carboxylicacid, 17-hydroxy-, Methyl ester, hydrochloride (1:1), (16b,17a,20a)-
  • YOHIMBINE HCL, ALPHA-
  • 20-alpha-yohimban-16-beta-carboxylicacid,17-alpha-hydroxy-,methylester,hyd
  • alpha-yohimbinhydrochloride
  • RAUWOLFSCINE HYDROCHLORIDE
  • RAUWOLSCINE
  • RAUWOLSCINE HCL
  • RAUWOLSCINE HYDROCHLORIDE
  • ISOYOHIMBINE
  • MESOYOHIMBINE
  • 20.alpha.-Yohimban-16.beta.-carboxylic acid, 17.alpha.-hydroxy-, methyl ester, monohydrochloride
  • Fauwolscine, hydrochloride
  • Nsc407307
  • Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, monohydrochloride, (16.beta.,17.alpha.,20.alpha.)-
  • 17α-Hydroxy-20α-yohimban-16β-carboxylicacid,methylesterhydrochloride
  • ALPHA-YOHIMBINE
  • ALPHA-YOHIMBINE HCL
  • ALPHA-YOHIMBINE HYDROCHLORIDE
  • methyl (16beta,17alpha,20alpha)-17-hydroxyyohimban-16-carboxylate hydrochloride
  • Rauwolscine hydrochloride, 98%, from Yohimbe
  • 17ALPHA-HYDROXY-20ALPHA-YOHIMBAN-16 BETA-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE
  • 17A-HYDROXY-20A-YOHIMBAN-16B-CARBOXYLIC ACID,METHYL ESTER HYDROCHLORIDE
  • Rauwolscine Hydrochloride,Rauwolscine
  • α-Yohimbine hydrochloride
  • Rauwolscine hydrochloride,α-Yohimbine,Corynanthidine,Rauwolscine,Adrenergic Receptor,Inhibitor,Beta Receptor,inhibit,Isoyohimbine
  • 17α-Hydroxy-20α-yohiMban-16β-carboxylicacid,Methylesterhydrochloride
  • Rauwolscine hydrochloride, alpha2 adrenergic antagonist
  • 6211-32-1
  • Adrenoceptor