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4-Piperidinopiperidine

Product Name
4-Piperidinopiperidine
CAS No.
4897-50-1
Chemical Name
4-Piperidinopiperidine
Synonyms
AKOS BB-9180;1,4'-bipiperidyl;1,4'-Bipiperidine;4-Piperidinopiperid;[1,4']BIPIPERIDINYL;3-Boc-aminopiperidin;1,4'-Bipiperidine 98%;1,4'-Bipiperidine,99%;4-Piperidinopiperdine;4-piperidonopiperidine
CBNumber
CB0388890
Molecular Formula
C10H20N2
Formula Weight
168.28
MOL File
4897-50-1.mol
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4-Piperidinopiperidine Property

Melting point:
64-66 °C (lit.)
Boiling point:
287.25°C (rough estimate)
Density 
0.9725 (rough estimate)
refractive index 
1.6011 (estimate)
storage temp. 
-20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Crystalline Solid
pka
10.31±0.10(Predicted)
color 
Light yellow to yellow-brown
InChI
InChI=1S/C10H20N2/c1-2-8-12(9-3-1)10-4-6-11-7-5-10/h10-11H,1-9H2
InChIKey
QDVBKXJMLILLLB-UHFFFAOYSA-N
SMILES
N1(C2CCNCC2)CCCCC1
CAS DataBase Reference
4897-50-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
3
HazardClass 
8
HS Code 
29339900
Storage Class
11 - Combustible Solids
Hazard Classifications
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
534498
Product name
4-Piperidinopiperidine
Purity
97%
Packaging
10g
Price
$103
Updated
2025/07/31
Sigma-Aldrich
Product number
534498
Product name
4-Piperidinopiperidine
Purity
97%
Packaging
50g
Price
$842
Updated
2023/06/20
TCI Chemical
Product number
P1638
Product name
4-Piperidinopiperidine
Purity
>98.0%(GC)
Packaging
1g
Price
$48
Updated
2025/07/31
TCI Chemical
Product number
P1638
Product name
4-Piperidinopiperidine
Purity
>98.0%(GC)
Packaging
5g
Price
$122
Updated
2025/07/31
TCI Chemical
Product number
P1638
Product name
4-Piperidinopiperidine
Purity
>98.0%(GC)
Packaging
25g
Price
$361
Updated
2025/07/31
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4-Piperidinopiperidine Chemical Properties,Usage,Production

Chemical Properties

light yellow to yellow-brown crystalline solid

Uses

Reactant for synthesis of: Arylthiadiazole H3 antagonists1 Water-soluble N-mustards as anticancer agents2 Antitubercular drugs3 Vasopressin1b receptor antagonists4 MDR modulators5 Selective Norepinephrine transporter inhibitors6

Uses

Reactant for synthesis of:
Arylthiadiazole H3 antagonists
Water-soluble N-mustards as anticancer agents
Antitubercular drugs
Vasopressin1b receptor antagonists
MDR modulators
Selective Norepinephrine transporter inhibitors

Definition

ChEBI: 1,4'-bipiperidine is a bipiperidine.

Synthesis

110-89-4

79099-07-3

4897-50-1

General procedure for the synthesis of 4-piperidinylpiperidine from hexahydropyridine and N-tert-butoxycarbonyl-4-piperidone: hexahydropyridine (1.549 g, 18.19 mmol), sodium triacetoxyborohydride (3.85 g, 19.2 mmol) and acetic acid (0.0910 g, 1.52 mmol) were added to a solution of 1-tert-butoxycarbonyl-4-piperidone (3.02 g , 15.2 mmol) in a solution of dichloromethane (25.0 mL). The reaction mixture was stirred at room temperature for 16 hours at 0 °C. Upon completion of the reaction, the reaction solution was cooled to 0 °C, the reaction was quenched by the addition of saturated aqueous sodium bicarbonate solution and extracted with dichloromethane. The organic layers were combined, dried with anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure. The residue was dissolved in 1.0 N hydrochloric acid and extracted with ethyl acetate. The aqueous phase was alkalized with 48% aqueous sodium hydroxide and extracted again with dichloromethane. The organic layer was dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure. The residue was dissolved in methanol (25.0 mL), concentrated hydrochloric acid (5.0 mL) was added and stirred at 40°C for 12 hours. After the reaction solution was concentrated and dried, the residue was dissolved in distilled water, alkalized with 48% aqueous sodium hydroxide and extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 4-(piperidin-1-yl)piperidine (2.04 g, 12.1 mmol, 80% yield) as a white solid.

References

[1] Patent: TW2016/2093, 2016, A. Location in patent: Paragraph 0317

4-Piperidinopiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Piperidinopiperidine Suppliers

Americas 1 Belgium 2 China 301 Europe 3 France 2 Germany 9 India 35 Japan 9 Russia 1 Slovakia 1 South Korea 3 Switzerland 3 The Netherlands 1 Ukraine 1 United Kingdom 15 United States 57 Global 444
Rushpharm Co.,Ltd.
Tel
025-66042949 15161141411
Fax
025-66042949
Email
2244332520@qq.com
Country
China
ProdList
55
Advantage
58
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
6058
Advantage
65
Suzhou ARTK Medchem Co., Ltd.
Tel
18168183658
Email
sales1@artkmedchem.com
Country
China
ProdList
740
Advantage
58
Nantong Xiaochang Pharmaceutical Trading Co., Ltd.
Tel
0513-82104991 18912868322
Fax
QQ1907456386
Email
sales11@btcpharm.com
Country
China
ProdList
1300
Advantage
58
Shanghai Yanze Chemical Co., Ltd
Tel
021-13621551597 19962611955
Email
260924549@qq.com
Country
China
ProdList
1633
Advantage
58
Shanghai Hobor Chemical Co., Ltd
Tel
021-57790084 13918007836
Fax
021-51685238
Email
sales@hoborchem.com
Country
China
ProdList
394
Advantage
60
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Sichuan Ruibo Technology Co., Ltd
Tel
+86-817-5586080
Fax
+86-817-5527378
Country
China
ProdList
42
Advantage
69
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
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View Lastest Price from 4-Piperidinopiperidine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4-Piperidinopiperidine 4897-50-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-17
ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD
Product
4-Piperidinopiperidine 4897-50-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5ton/month
Release date
2023-12-09
Anhui Ruihan Technology Co., Ltd
Product
4-Piperidinopiperidine 4897-50-1
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2023-09-12

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