7-Ethylcamptothecin

Product Name: 7-Ethylcamptothecin
CAS No.: 78287-27-1
Chemical Name: 7-Ethylcamptothecin
Synonyms: SN 22;7-Ethylcamptothecin;7-Etyl-camptothecin;7-Ethylcamptotrecin;Irinotecan USP RC E;Irinotecan Impurity 16;7-Ethylcamptothecin>Irinotecan EP Impurity F;(S)-7-Ethyl Camptothecin;(S)-4,11-diethyl-4-hydroxy-1H
CBNumber: CB4511609
Molecular Formula: C22H20N2O4
Formula Weight: 376.41
MOL File: 78287-27-1.mol

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7-Ethylcamptothecin Property

Melting point:: 236-241°C
Boiling point:: 752.9±60.0 °C(Predicted)
Density: 1.43
storage temp.: Sealed in dry,2-8°C
solubility: Chloroform and Methanol Mixture (Slightly, Heated, Sonicated), DMSO (Slightly, Heated)
pka: 11.24±0.20(Predicted)
form: Solid
color: Pale Yellow to Light Orange
InChI: InChI=1S/C22H20N2O4/c1-3-12-13-7-5-6-8-17(13)23-19-14(12)10-24-18(19)9-16-15(20(24)25)11-28-21(26)22(16,27)4-2/h5-9,27H,3-4,10-11H2,1-2H3/t22-/m0/s1
InChIKey: MYQKIWCVEPUPIL-JOCHJYFZSA-N
SMILES: N1C2C(=CC=CC=2)C(CC)=C2CN3C(C=12)=CC1[C@](CC)(O)C(=O)OCC=1C3=O
CAS DataBase Reference: 78287-27-1(CAS DataBase Reference)

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Safety

Risk Statements: 23/34/35
Safety Statements: 3/14-6-36/37/39
RIDADR: 1544
HazardClass: 6.1
PackingGroup: III
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS000008
Product name: 7-Ethylcamptothecin
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 10 mg
Price: $87.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1347664
Product name: Irinotecan Related Compound E
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 15MG
Price: $1200
Updated: 2025/07/31

TCI Chemical

Product number: E0781
Product name: 7-Ethylcamptothecin
Purity: >96.0%(HPLC)
Packaging: 1g
Price: $187
Updated: 2025/07/31

TCI Chemical

Product number: E0781
Product name: 7-Ethylcamptothecin
Purity: >96.0%(HPLC)
Packaging: 100mg
Price: $31
Updated: 2025/07/31

TRC

Product number: E900830
Product name: 7-EthylCamptothecin
Packaging: 10mg
Price: $130
Updated: 2021/12/16

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7-Ethylcamptothecin Chemical Properties,Usage,Production

Chemical Properties

Light Pink Solid

Uses

An anticancer drug, showed strong activity against various murine tumors. A Camptothecin (CPT) derivative as antineoplastic agent against drug-resistant tumors. Irinotecan USP Related Compound E.

Definition

ChEBI: 7-ethylcamptothecin is a pyranoindolizinoquinoline.

Biological Activity

7-Ethylcamptothecin is one of the camptothecin analogs. Camptothecin (CPT), a cytotoxic alkaloid isolated from camptothecin analogues, has strong antitumor activity against L1210 leukemia and Walker 256 carcinosarcoma models.

Synthesis

123-38-6

7689-03-4

78287-27-1

To a 5L reactor were added 80 g of (S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (camptothecin), 840 g of glacial acetic acid, and 368 g of concentrated sulfuric acid, and mechanical stirring was initiated until complete dissolution. Subsequently, 80 g of propionaldehyde was slowly added and 102 g of hydrogen peroxide was added dropwise. The reaction temperature was controlled in the range of -5 to 5°C for 10 minutes. After completion of the reaction, 10 kg of pure water was added to the system and stirring was continued for 2 hours. The precipitate was collected by filtration to give 72.5 g of (S)-4,11-diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolo[1,2-b]quinoline-3,14(4H,12H)-dione (7-ethylcamptothecin) in 95.4% yield.

References

[1] Patent: CN108484624, 2018, A. Location in patent: Paragraph 0031; 0039; 0043; 0044
[2] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 6, p. 1446 - 1454
[3] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 10, p. 2574 - 2580
[4] Patent: WO2006/16203, 2006, A1. Location in patent: Page/Page column 9-10
[5] European Journal of Pharmaceutical Sciences, 2018, vol. 123, p. 546 - 559

7-Ethylcamptothecin Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Ethylcamptothecin Suppliers

Americas 1 Canada 1 China 288 Czech Republic 1 Europe 3 Germany 2 India 17 Japan 1 Switzerland 1 United Kingdom 1 United States 34 Global 350

Nanjing Duolong Bio-tech Co.,Ltd.

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SiChuang NanBu Honesty Technology Co., Ltd.

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J & K SCIENTIFIC LTD.

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Chembest Research Laboratories Limited

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
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View Lastest Price from 7-Ethylcamptothecin manufacturers

Shaanxi Xianhe Biotech Co., Ltd

Product: 7-Ethylcamptothecin 78287-27-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-17

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: 7-Ethylcamptothecin 78287-27-1 78287-27-1
Price: US $28.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: 1000.00 kgs
Release date: 2019-07-09

Career Henan Chemical Co

Product: 7-Ethylcamptothecin 78287-27-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2018-08-13

78287-27-1, 7-EthylcamptothecinRelated Search:

Irinotecan Hydroxyl Acid Irinotecan IMpurity G Irinotecan Impurity 18 12-Hydroxy Irinotecan Irinotecan Lactone IMpurity 12-ethyl-8-methyl-9-oxo-7-propionyl-9,11-dihydroindolizino[1,2-b]quinolin-2-yl [1,4'-bipiperidine]-1'-carboxylate 10-Nitrocamptothecin (+)-Camptothecin 10-Hydroxycamptothecin 4-Ethyl-4,10-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Irinotecan Impurity 19 Irinotecan Impurity 29 [1,4'-Bipiperidine]-1'-carboxylic acid sodium:(2S)-2-[12-ethyl-8-(hydroxymethyl)-9-oxo-2-(4-piperidin-1-ylpiperidine-1-carbonyl)oxy-11H-indolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoate 11-Desethyl Irinotecan Irinotecan Impurity 26 Irinotecan 7,11-Diethyl-10-hydroxycaMptothecin

IRINOTECAN EP IMPURITY F (7-ETHYL CAMPTOTHECIN)

(S)-4,11-diethyl-4-hydroxy-1H

7-Ethylcamptothecin 78287-27-1

Irinotecan EP Impurity F

(S)-4,11-Diethyl-4-hydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione

(4S)-4,11-Diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

SN 22

7-Ethylcamptotrecin

7-Etyl-camptothecin

(4S)-4,11-Diethyl-4-hydroxy-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione

7-Ethylcamptothecin

CaMptothecin 7-Ethyl IMpurity

Irinotecan Related CoMpound E

Irinotecan Related Compound E (15 mg) ((S)-4,11-Diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)

Irinotecan Impurity 16

Irinotecan USP RC E

7-ETHYL-CAMPTOTHECIN,HPLC 99%

Irinotecan Hydrochloride impurity F

7-Ethylcamptothecin&gt

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4-hydroxy-, (4S)-

7-Ethyl camptothecin USP/EP/BP

7-ethyl CamptothecinQ: What is 7-ethyl Camptothecin Q: What is the CAS Number of 7-ethyl Camptothecin Q: What is the storage condition of 7-ethyl Camptothecin Q: What are the applications of 7-ethyl Camptothecin

Irinotecan Related Compound E ((S)-4,11-Diethyl-4-hydroxy-1H-pyrano[3'',4'':6,7]indolizino[1,2-b]quin (1347664)

(S)-4,11-diethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione

Irinotecan USP Related Compound E

(19S)-10,19-diethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione

Irinotecan Hydrochloride Trihydrate Impurity F

Irinotecan Hydrochloride Trihydrate EP Impurity F

7-Ethylcamptothecin, 99% (Custom

(S)-7-Ethyl Camptothecin

(S)-4,11-Diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

(S)-4,11-Diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (7-Ethy

7-Ethylcamptothecin, 10 mM in DMSO

(S)-4,11-Diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (7-Ethyl-20(S)-camptothecin)

78287-27-1

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