(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID

Product Name: (4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID
CAS No.: 54699-92-2
Chemical Name: (4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID
Synonyms: AKOS BB-5221;AKOS BBS-00002665;4-METHYL PIPERAZINE-ACETIC ACID;(4-METHYLPIPERAZINO)ACETIC ACID;4-METHYLPIPERAZINE-1-ACETIC ACID;4-Methyl-1-piperazin acetic acid;4-METHYL-1-PIPERAZINE ACETIC ACID;1-Piperazineacetic acid, 4-Methyl-;(Carboxymethyl)-N'-methylpiperazine;(4-METHYL-1-PIPERAZINYL)ACETIC ACID
CBNumber: CB5494642
Molecular Formula: C7H14N2O2
Formula Weight: 158.2
MOL File: 54699-92-2.mol

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(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID Property

Melting point:: 130-133°C
Boiling point:: 278℃
Density: 1.123
Flash point:: 122℃
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 1.85±0.10(Predicted)
color: Off-white
InChI: InChI=1S/C7H14N2O2/c1-8-2-4-9(5-3-8)6-7(10)11/h2-6H2,1H3,(H,10,11)
InChIKey: JCXZKUZXVQKENT-UHFFFAOYSA-N
SMILES: N1(CC(O)=O)CCN(C)CC1
CAS DataBase Reference: 54699-92-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-41-37/38
Safety Statements: 26-36/37/39-39
HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: C180700
Product name: (Carboxymethyl)-N''-methylpiperazine
Packaging: 2.5g
Price: $1320
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0015537
Product name: (4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID
Purity: 95.00%
Packaging: 1G
Price: $637.56
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-28
Product name: 2-(4-Methylpiperazin-1-yl)acetic acid
Purity: 98.0%
Packaging: 5G
Price: $237
Updated: 2021/12/16

Matrix Scientific

Product number: 008488
Product name: (4-Methyl-piperazin-1-yl)-acetic acid
Packaging: 5g
Price: $237
Updated: 2021/12/16

AK Scientific

Product number: W6892
Product name: (4-Methyl-1-piperazinyl)aceticacid
Packaging: 1g
Price: $34
Updated: 2021/12/16

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(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID Chemical Properties,Usage,Production

Uses

(Carboxymethyl)-N''-methylpiperazine acts as a potential antibacterial compound, due to its nocathiacin analog.

Uses

(Carboxymethyl)-N'-methylpiperazine acts as a potential antibacterial compound, due to its nocathiacin analog.

Synthesis

28920-67-4

54699-92-2

b) Synthesis of 4-methyl-1-piperazinylacetic acid Ethyl (4-methyl-1-piperazinyl) acetate (1.3 g, 6.50 mmol, 1.0 eq.) was dissolved in 8N hydrochloric acid and the reaction was stirred at 95°C for 16 hours. After completion of the reaction, the reaction solution was concentrated by vacuum rotary evaporator. The remaining hydrochloric acid was neutralized with sodium bicarbonate solution and subsequently extracted with ethyl acetate (3 x 10 ml). The organic phases were combined, washed sequentially with water and saturated saline and dried over anhydrous sodium sulfate. The organic solvent was removed by distillation under reduced pressure to afford the target product 4-methyl-1-piperazineacetic acid in 54.5% yield (0.6 g).LC-MS (ESI) analysis: theoretical mass: 158.0; measured mass: 159.1 [M + H]+ (retention time: 0.102 min).

References

[1] Patent: WO2013/53983, 2013, A1. Location in patent: Page/Page column 38
[2] Journal of Medicinal Chemistry, 2000, vol. 43, # 8, p. 1489 - 1494
[3] Patent: EP2107054, 2009, A1. Location in patent: Page/Page column 26

(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID Preparation Products And Raw materials

Raw materials

1-Methylpiperazine Ethyl bromoacetate Diethyl ether Benzene Ethyl acetate Methanol Sodium hydroxide

Preparation Products

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(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID Suppliers

Canada 1 China 82 Europe 1 Germany 6 India 5 Russia 1 Ukraine 1 United Kingdom 6 United States 23 Global 126

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View Lastest Price from (4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID manufacturers

Honest Joy Holdings Limited

Product: (4-Methyl-piperazin-1-yl)-aceticacid 54699-92-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.3%
Supply Ability: 100 tons
Release date: 2022-01-14

Career Henan Chemical Co

Product: (4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID 54699-92-2
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-03

54699-92-2, (4-METHYL-PIPERAZIN-1-YL)-ACETIC ACIDRelated Search:

Cinepazic Acid cinepazet 1-Piperazineaceticacid, 4-(phenylmethyl)-, hydrazide Fmoc-4-carboxymethyl-piperazine 4-[2-(FMOC-AMINO)ETHYL]-1-PIPERAZINEACETIC ACID DIHYDROCHLORIDE ETHYL 2-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)ACETATE AKOS BB-5220 Apicycline 4-(4-ISOPROPYLPHENYL)-2-(4-METHYLPIPERAZINO)-4-OXOBUTANOIC ACID METHYL 7-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)ETHYL)-5,8-DIOXOHEXAHYDRO[1,3]THIAZOLO[3,4-A]PYRAZINE-3-CARBOXYLATE 4-[4-(TERT-BUTYL)PHENYL]-2-(4-METHYLPIPERAZINO)-4-OXOBUTANOIC ACID METHYL 7-(4-CHLOROBENZYL)-5,8-DIOXOHEXAHYDRO[1,3]THIAZOLO[3,4-A]PYRAZINE-3-CARBOXYLATE 4-(4-CHLOROPHENYL)-2-(4-METHYLPIPERAZINO)-4-OXOBUTANOIC ACID METHYL 7-BENZYL-5,8-DIOXOHEXAHYDRO[1,3]THIAZOLO[3,4-A]PYRAZINE-3-CARBOXYLATE METHYL 5,8-DIOXO-7-PHENETHYLHEXAHYDRO[1,3]THIAZOLO[3,4-A]PYRAZINE-3-CARBOXYLATE METHYL 5,8-DIOXO-7-[2-(2-PYRIDINYL)ETHYL]HEXAHYDRO[1,3]THIAZOLO[3,4-A]PYRAZINE-3-CARBOXYLATE 4-(4-BROMOPHENYL)-2-(4-METHYLPIPERAZINYL)-4-OXOBUTANOIC ACID 4-(4-METHYLPHENYL)-2-(4-METHYLPIPERAZINO)-4-OXOBUTANOIC ACID

1-Piperazineaceticacid,4-methyl-(9CI)

(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID >98%

1-Piperazineacetic acid, 4-Methyl-

N-(Carboxymethyl)-N'-methylpiperazine

(Carboxymethyl)-N'-methylpiperazine

2-(4-METHYLPIPERAZIN-1-YL)ACETIC ACID

AKOS BB-5221

AKOS BBS-00002665

(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID

4-METHYLPIPERAZINE-1-ACETIC ACID

4-METHYL PIPERAZINE-ACETIC ACID

(4-METHYLPIPERAZINO)ACETIC ACID

(4-METHYL-1-PIPERAZINYL)ACETIC ACID

4-METHYL-1-PIPERAZINE ACETIC ACID

(4-Methylpiperazino)acetic acid 4-Methylpiperazine-1-acetic acid

(4-Methyl-piperazin-1-yl)-aceticaci

(4-Methyl-piperazin-1-yl)-acetic ac

4-Methyl-1-piperazin acetic acid

4-Methyl-1-piperazine acetic acid, 95%

54699-92-2

piperazines

PIPERIDINE