1-Methylpiperazine Property

Melting point:

-6 °C

Boiling point:

138 °C(lit.)

Density 

0.903 g/mL at 25 °C(lit.)

vapor density 

3.5 (vs air)

vapor pressure 

12 hPa (20 °C)

refractive index 

n20/D 1.466(lit.)

Flash point:

108 °F

storage temp. 

2-8°C

solubility 

Chloroform (Soluble), Methanol (Soluble)

pka

pK1:4.94(+2);pK2:9.09(+1) (25°C,μ=0.1)

form 

Liquid

Specific Gravity

0.903

color 

Clear

PH

11-12 (50g/l, H2O, 20℃)

explosive limit

1.2-9.9%(V)

Water Solubility 

soluble

Sensitive 

Hygroscopic

BRN 

102724

InChIKey

PVOAHINGSUIXLS-UHFFFAOYSA-N

LogP

-0.57 at 25℃

CAS DataBase Reference

109-01-3(CAS DataBase Reference)

NIST Chemistry Reference

Piperazine, 1-methyl-(109-01-3)

EPA Substance Registry System

Piperazine, 1-methyl- (109-01-3)

Safety

Hazard Codes 

T,F,C,Xi

Risk Statements 

10-21-23-34-36/37/38-20/21

Safety Statements 

16-26-36/37/39-45-36

RIDADR 

UN 2734 8/PG 2

WGK Germany 

2

RTECS 

TM1225000

Autoignition Temperature

320 °C

Hazard Note 

Flammable/Toxic/Corrosive/Store under nitrogen

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29335995

Toxicity

LD50 orally in Rabbit: 2547 mg/kg LD50 dermal Rabbit 1341 mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H331Toxic if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

1-Methylpiperazine Chemical Properties,Usage,Production

Chemical Properties

clear liquid

Uses

1-Methylpiperazine is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP)

Uses

1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.

Definition

ChEBI: 1-Methylpiperazine is a N-methylpiperazine.

Hazard

Moderate fire risk.

Flammability and Explosibility

Flammable

Safety Profile

Poison by intraperitoneal route. Moderately toxic by inhalation, ingestion, and skin contact. A severe skin and eye irritant. Flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx.