3-(4-Methylpiperazin-1-yl)aniline

Uses

Product Name: 3-(4-Methylpiperazin-1-yl)aniline
CAS No.: 148546-99-0
Chemical Name: 3-(4-Methylpiperazin-1-yl)aniline
Synonyms: AKOS BB-8951;3-(4-Methylpiperazine) aniline;3-(4-Methypiperazin-1-yl)anilin;3-(4-METHYLPIPERAZIN-1-YL)ANILINE;3-(4-Methyl-1-piperazinyl)aniline;1-(3-Aminophenyl)-4-methylpiperazine;3-(4-Methyl-1-piperazinyl)aniline >3-(4-Methylpiperazin-1-yl)aniline 97%;3-(4-methylpiperazin-1-yl)benzenamine;3-(4-Methylpiperazin-1-yl)aniline ,97%
CBNumber: CB0487397
Molecular Formula: C11H17N3
Formula Weight: 191.27
MOL File: 148546-99-0.mol

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3-(4-Methylpiperazin-1-yl)aniline Property

Melting point:: 98-99
Boiling point:: 353.1±37.0 °C(Predicted)
Density: 1.092±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 7.88±0.42(Predicted)
color: White to Yellow to Orange
InChI: InChI=1S/C11H17N3/c1-13-5-7-14(8-6-13)11-4-2-3-10(12)9-11/h2-4,9H,5-8,12H2,1H3
InChIKey: RJGHJWKQCJAJEP-UHFFFAOYSA-N
SMILES: C1(N)=CC=CC(N2CCN(C)CC2)=C1
CAS DataBase Reference: 148546-99-0

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Safety

Hazard Codes: C
Risk Statements: 20/21/22-34
Safety Statements: 22-26-36/37/39-45
RIDADR: 2923
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: III
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS004833
Product name: 3-(4-methylpiperazin-1-yl)aniline
Purity: AldrichCPR
Packaging: 100mg
Price: $68.1
Updated: 2023/06/20

TCI Chemical

Product number: A2714
Product name: 3-(4-Methyl-1-piperazinyl)aniline
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $37
Updated: 2025/07/31

TCI Chemical

Product number: A2714
Product name: 3-(4-Methyl-1-piperazinyl)aniline
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $147
Updated: 2025/07/31

TRC

Product number: M218935
Product name: 3-(4-Methylpiperazin-1-yl)aniline
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR9659
Product name: 3-(4-Methylpiperazin-1-yl)aniline
Purity: 98%
Packaging: 1g
Price: $10
Updated: 2021/12/16

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3-(4-Methylpiperazin-1-yl)aniline Chemical Properties,Usage,Production

Uses

3-(4-methylpiperazin-1-yl)aniline is an amine derivative used in organic and pharmaceutical synthesis.

Chemical Properties

Yellow solid

Synthesis

148546-97-8

148546-99-0

Step - (ii): Synthesis of 3-(4-methylpiperazin-1-yl)aniline: A methanolic solution of 1-methyl-4-(3-nitrophenyl)piperazine (15 g, 78.5 mmol) was mixed with a methanolic solution of 10% Pd/C (3 g) under stirring. The reaction was carried out under inert atmosphere with slow stirring and under hydrogen atmosphere for 4 hours at room temperature. After completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad. The filtrate was concentrated to afford the target product 3-(4-methylpiperazin-1-yl)aniline (11 g, 87%) as a light yellow solid. Mass spectrum (electrospray ionization) m/z: 192 (M + 1).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 17, p. 5221 - 5224
[2] Patent: WO2007/18941, 2007, A2. Location in patent: Page/Page column 96-97
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 12, p. 5099 - 5119
[4] RSC Advances, 2018, vol. 8, # 22, p. 11871 - 11885
[5] Patent: WO2014/125410, 2014, A1. Location in patent: Page/Page column 39; 40

3-(4-Methylpiperazin-1-yl)aniline Preparation Products And Raw materials

Raw materials

Stannous chloride dihydrate 1-Methylpiperazine Dimethyl sulfoxide 1-Fluoro-3-nitrobenzene

Preparation Products

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3-(4-Methylpiperazin-1-yl)aniline Suppliers

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3-(4-Methylpiperazin-1-yl)aniline ,97%

3-(4-methylpiperazin-1-yl)benzenamine

Benzenamine, 3-(4-methyl-1-piperazinyl)-

3-(4-Methypiperazin-1-yl)anilin

1-(3-Aminophenyl)-4-methylpiperazine

3-(4-Methyl-1-piperazinyl)aniline

3-(4-METHYLPIPERAZIN-1-YL)ANILINE

AKOS BB-8951

Benzenamine, 3-(4-methyl-1-piperazinyl)- (9CI)

3-(4-Methylpiperazin-1-yl)aniline 97%

3-(4-Methyl-1-piperazinyl)aniline &gt

3-(4-Methylpiperazine) aniline

148546-99-0

PIPERIDINE

Amines and Anilines