4-(4-Methylpiperazino)aniline

Product Name: 4-(4-Methylpiperazino)aniline
CAS No.: 16153-81-4
Chemical Name: 4-(4-Methylpiperazino)aniline
Synonyms: 4-(4-METHYLPIPERAZIN-1-YL)ANILINE;1-(4-AMINOPHENYL)-4-METHYLPIPERAZINE;4-(4-methylpiperazin-1-yl)benzenamine;4-Methyl-1-(4-aminophenyl)piperazine;4-(4-MethyL;AKOS B021941;AKOS BB-8657;piperazino)aniL;ART-CHEM-BB B021941;OTAVA-BB BB7110920492
CBNumber: CB8669359
Molecular Formula: C11H17N3
Formula Weight: 191.27
MOL File: 16153-81-4.mol

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4-(4-Methylpiperazino)aniline Property

Melting point:: 89 °C
Boiling point:: 180°C/5mmHg(lit.)
Density: 1.092±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO (Sparingly), Methanol (Slightly)
form: Solid
pka: 8.08±0.42(Predicted)
color: Very Dark Gray to Black
Sensitive: Air Sensitive
InChI: InChI=1S/C11H17N3/c1-13-6-8-14(9-7-13)11-4-2-10(12)3-5-11/h2-5H,6-9,12H2,1H3
InChIKey: MOZNZNKHRXRLLF-UHFFFAOYSA-N
SMILES: C1(N)=CC=C(N2CCN(C)CC2)C=C1
CAS DataBase Reference: 16153-81-4(CAS DataBase Reference)

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-36/37/39-45
RIDADR: 3259
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: III
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H332Harmful if inhaled

Precautionary statements

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2154
Product name: 4-(4-Methyl-1-piperazinyl)aniline
Purity: >98.0%(GC)
Packaging: 1g
Price: $24
Updated: 2025/07/31

TCI Chemical

Product number: M2154
Product name: 4-(4-Methyl-1-piperazinyl)aniline
Purity: >98.0%(GC)
Packaging: 5g
Price: $70
Updated: 2025/07/31

TRC

Product number: M325445
Product name: 4-(4-Methylpiperazino)aniline
Packaging: 1g
Price: $50
Updated: 2021/12/16

Oakwood

Product number: 033694
Product name: 4-(4-Methylpiperazino)aniline
Purity: 97%
Packaging: 5g
Price: $30
Updated: 2021/12/16

Apolloscientific

Product number: OR8114
Product name: 4-(4-Methylpiperazin-1-yl)aniline
Purity: 99%
Packaging: 5g
Price: $32
Updated: 2021/12/16

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4-(4-Methylpiperazino)aniline Chemical Properties,Usage,Production

Chemical Properties

Purple solid

Uses

4-(4-Methylpiperazino)aniline is a reagent in the preparation of benzyloxypyridinone derivative which has c-Met kinase inhibitor properties.

Synthesis

16155-03-6

16153-81-4

GENERAL METHOD: 1-methyl-4-(4-nitrophenyl)piperazine (5.53 mmol) was dissolved in methanol (15 mL) and stirred under N2 atmosphere. Pd/C (2.78 mmol) was added to this solution. Subsequently, the reaction flask was placed in H2 atmosphere (balloon) for hydrogenation reaction overnight. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth plate and the filtrate was concentrated under vacuum. The crude product was purified by silica gel column chromatography (eluent: 5% MeOH/DCM containing 1% NH3) to afford the target compound 4-(4-methyl-1-piperazinyl)aniline (3a) as a brown solid in 87% yield.

References

[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 26, p. 8261 - 8269
[2] European Journal of Medicinal Chemistry, 2016, vol. 124, p. 896 - 905
[3] Patent: US6569878, 2003, B1
[4] Patent: EP1215208, 2002, A2. Location in patent: Example C(70)
[5] Patent: WO2012/110773, 2012, A1. Location in patent: Page/Page column 58; 59

4-(4-Methylpiperazino)aniline Preparation Products And Raw materials

Raw materials

4-Chloronitrobenzene N,N-Dimethylformamide Palladium hydroxide 1-Methylpiperazine Potassium carbonate Chloroform Ethyl acetate Methanol Dimethyl sulfoxide

Preparation Products

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4-(4-Methylpiperazino)aniline Suppliers

Americas 1 Belgium 1 China 277 Europe 2 France 2 Germany 5 India 8 Japan 1 Russia 2 Switzerland 1 Ukraine 1 United Kingdom 11 United States 29 Global 341

Beijing Haite lesk Technology Co., Ltd

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Energy Chemical

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View Lastest Price from 4-(4-Methylpiperazino)aniline manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4-(4-Methylpiperazino)aniline 16153-81-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

Zhejiang J&C Biological Technology Co.,Limited

Product: 4-(4-Methylpiperazino)aniline 16153-81-4
Price: US $0.00/gram
Min. Order: 1gram
Purity: 99%
Supply Ability: 10kg
Release date: 2022-02-17

Honest Joy Holdings Limited

Product: 4-(4-Methylpiperazino)aniline 16153-81-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.6%
Supply Ability: 100 tons
Release date: 2022-02-08

16153-81-4, 4-(4-Methylpiperazino)anilineRelated Search:

1,2-Dimethylhydrazine Dihydrochloride N,N-Dimethyl-1,4-phenylenediamine 1-BENZHYDRYLPIPERAZINE 4-Aminobenzotrifluoride Aniline 3,3',5,5'-Tetramethylbenzidine dihydrochloride Dichloromethylphenylsilane N-Methylaniline 1-Methylpiperazine ANILINE BLACK N,N-Dimethylaniline 3,4'-DIAMINODIPHENYLMETHANE p-Toluidine Tris(hydroxymethyl)aminomethane 4-(4-methylpiperazin-1-yl)aniline Benzenamine, 4-(4-methyl-1-piperazinyl)-, monohydrochloride 1-METHYL-4-(4-NITROPHENYL)PIPERAZINE 2-(4-Methylpiperazin-1-yl)aniline

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16153-81-4

C11H18N3

C11H17N3

Phenyls & Phenyl-Het

Piperazines

Phenyls & Phenyl-Het

Piperaizine

API intermediates

Piperazidine intermediates

PIPERIDINE

Amines and Anilines

Heterocycles

Amines