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1-METHYL-4-(4-NITROBENZYL)PIPERAZINE

Product Name
1-METHYL-4-(4-NITROBENZYL)PIPERAZINE
CAS No.
70261-81-3
Chemical Name
1-METHYL-4-(4-NITROBENZYL)PIPERAZINE
Synonyms
SKL601;1-(4-Nitrobenzyl)-4-methylpiperazine;1-METHYL-4-(4-NITROBENZYL)PIPERAZINE;1-Methyl-4-(4-nitrobenzyl)piperazine95%;1-Methyl-4-[(4-nitrophenyl)Methyl]piperazine;1-(4-Methyl-3-nitrobenzyl)-4-Methylpiperazine;Piperazine, 1-methyl-4-[(4-nitrophenyl)methyl]-;1-methyl-4-[(4-nitrophenyl)methyl]piperazine-1,4-diium;1-METHYL-4-[(4-NITROPHENYL)METHYL]-PIPERAZINE DIHYDROCHLORIDE
CBNumber
CB9773376
Molecular Formula
C12H17N3O2
Formula Weight
235.28
MOL File
70261-81-3.mol
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1-METHYL-4-(4-NITROBENZYL)PIPERAZINE Property

Boiling point:
358.2±27.0 °C(Predicted)
Density 
1.184±0.06 g/cm3(Predicted)
pka
7.51±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M219360
Product name
1-Methyl-4-(4-nitrobenzyl)piperazine
Packaging
100mg
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
071888
Product name
1-Methyl-4-(4-nitrobenzyl)piperazine
Purity
95+%
Packaging
1g
Price
$185
Updated
2021/12/16
SynQuest Laboratories
Product number
4H54-1-GC
Product name
1-(4-Nitrobenzyl)-4-methylpiperazine
Packaging
1g
Price
$202
Updated
2021/12/16
AK Scientific
Product number
W7979
Product name
1-Methyl-4-(4-nitrobenzyl)piperazine
Packaging
5g
Price
$244
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
COR0001357
Product name
1-METHYL-4-(4-NITROBENZYL)PIPERAZINE
Purity
95.00%
Packaging
1G
Price
$780.78
Updated
2021/12/16
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1-METHYL-4-(4-NITROBENZYL)PIPERAZINE Chemical Properties,Usage,Production

Synthesis

109-01-3

555-16-8

70261-81-3

GENERAL PROCEDURE: Acetic acid (AcOH, 100%, 140 mL, 2.44 mol) was added slowly and dropwise over a period of 1 hour to a flask containing sodium hydride (NaBH4, 20.0 g, 0.53 mol) and chloroform (CHCl3, 220 mL) stirred at 0-5° C. The mixture was then stirred for 1.5 hours. The resulting mixture was continued to be stirred at 0-5°C for 1.5 hours. Subsequently, a solution of N-methylpiperazine (28.0 mL, 0.25 mol) and p-nitrobenzaldehyde (43.4 g, 0.26 mol) dissolved in chloroform (60 mL) was added to the above mixture. The reaction mixture was stirred at 0-5°C for 1 hour and then at room temperature for 12 hours. After completion of the reaction, the mixture was treated with distilled water (150 mL) and sodium carbonate (Na2CO3) and the pH was adjusted to 8.0-9.0. The aqueous phase was extracted with ethyl acetate (EtOAc, 2 x 100 mL), the organic layers were combined, washed with distilled water (1 x 100 mL) and dried over anhydrous sodium sulfate (Na2SO4). Filtration and evaporation of the solvent gave 1-methyl-4-(4-nitrophenyl)piperazine (4a) as a pale yellow oil; yield: 61.6 g, 99% yield.

References

[1] Tetrahedron Letters, 2012, vol. 53, # 38, p. 5056 - 5058
[2] Russian Journal of Organic Chemistry, 2013, vol. 49, # 4, p. 563 - 567
[3] Zh. Org. Khim., 2013, vol. 49, # 4, p. 580 - 584
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 21, p. 8801 - 8815
[5] Russian Journal of Organic Chemistry, 2011, vol. 47, # 10, p. 1556 - 1563

1-METHYL-4-(4-NITROBENZYL)PIPERAZINE Preparation Products And Raw materials

Raw materials

Sodium chloride 1-Methylpiperazine Triethylamine Dichloromethane 4-Nitrobenzyl chloride

Preparation Products

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1-METHYL-4-(4-NITROBENZYL)PIPERAZINE Suppliers

China 39 Germany 2 India 2 United Kingdom 5 United States 11 Global 59
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
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001-617-206-9595
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sales@chemreagents.com
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United States
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10186
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62
Tetranov Biopharm
Tel
13526569071
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sales@leadmedpharm.com
Country
China
ProdList
7892
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64
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
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China
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9891
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58
9ding chemical ( Shanghai) Limited
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4009209199
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86-021-52271987
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sales@9dingchem.com
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China
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18209
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Shanghai XinKai Chemical Technology Co., Ltd.
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021-58930698 15921516558
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86-021-58933679
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zhangyichao84@126.com
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China
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Shanghai JiYi Biotechnology Co. Ltd.
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13621943973
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sales@shjiyipharmatech.com
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China
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Cool Pharm, Ltd
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021-60455363 18019463053
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50966098
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sales@coolpharm.com
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China
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12346
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Chengdu Research Accelerators Technology Co., Ltd.
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028-64353063
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028-64353063 QQ:784253935
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reacchemical@163.com
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China
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Zhengzhou Alfachem Co., Ltd.
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0371-53765687 18937137882
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QQ:2885373884
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2853979813@qq.com
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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71826
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View Lastest Price from 1-METHYL-4-(4-NITROBENZYL)PIPERAZINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
1-METHYL-4-(4-NITROBENZYL)PIPERAZINE 70261-81-3
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2024-09-01
Career Henan Chemical Co
Product
1-METHYL-4-(4-NITROBENZYL)PIPERAZINE 70261-81-3
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-02

70261-81-3, 1-METHYL-4-(4-NITROBENZYL)PIPERAZINERelated Search:

1-METHYL-4-(4-NITROBENZYL)PIPERAZINE 1-METHYL-4-(3-NITROBENZYL)PIPERAZINE,1-Methyl-4-(3-nitrobenzyl)piperazine 97% 2-[4-(4-NITROBENZYL)PIPERAZINO]ETHAN-1-OL 1-BENZYL-4-(4-NITROBENZYL)PIPERAZINE 1-ETHYL-4-(4-NITROBENZYL)PIPERAZINE 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-[BIS(4-FLUOROPHENYL)METHYL]-4-(4-NITROBENZYL)PIPERAZINE 2-AMINO-1-[4-(4-NITRO-BENZOYL)-PIPERAZIN-1-YL]-ETHANONE CYCLOHEXYL[4-(4-NITROBENZOYL)PIPERAZINO]METHANONE 3-AMINO-1-[4-(4-NITRO-BENZOYL)-PIPERAZIN-1-YL]-PROPAN-1-ONE AURORA 10856 4-CHLORO-1-((4-NITROPHENYL)(4-PHENYLPIPERAZINYL)METHYLTHIO)BENZENE BUTTPARK 18\02-54 2,3-Piperazinedione, 1-((4-nitrophenyl)methyl)-4-((4-(2-pyrimidinylami no)phenyl)methyl)- AKOS BB-6378 2-[4-(4-NITROBENZYL)PIPERAZINO]-1,3-BENZOTHIAZOLE 4-(4-NITRO-BENZOYL)-PIPERAZINE-1-CARBOXAMIDINE 2-CHLORO-1-[4-(4-NITRO-BENZOYL)-PIPERAZIN-1-YL]-ETHANONE

  • 1-Methyl-4-(4-nitrobenzyl)piperazine95%
  • 1-METHYL-4-(4-NITROBENZYL)PIPERAZINE
  • 1-METHYL-4-[(4-NITROPHENYL)METHYL]-PIPERAZINE DIHYDROCHLORIDE
  • 1-Methyl-4-[(4-nitrophenyl)Methyl]piperazine
  • 1-(4-Methyl-3-nitrobenzyl)-4-Methylpiperazine
  • 1-methyl-4-[(4-nitrophenyl)methyl]piperazine-1,4-diium
  • 1-(4-Nitrobenzyl)-4-methylpiperazine
  • Piperazine, 1-methyl-4-[(4-nitrophenyl)methyl]-
  • SKL601
  • 70261-81-3
  • API intermediates