ChemicalBook > CAS DataBase List > 1-AdaMantanethylaMine

1-AdaMantanethylaMine

Description References

Product Name: 1-AdaMantanethylaMine
CAS No.: 13392-28-4
Chemical Name: 1-AdaMantanethylaMine
Synonyms: RIMANTADINE;LEVOFLOXACIN HCL;RiMantidine;1-Adamantanemethylamine;RiMantadine (FluMadine);1-Adaman;AKOS B022266;1-Rimantadine;AKOS NCG1-0034;1-Adamantanethylamine
CBNumber: CB7122907
Molecular Formula: C12H21N
Formula Weight: 179.3
MOL File: 13392-28-4.mol

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1-AdaMantanethylaMine Property

Boiling point:: 248°C
Density: 1.033
Flash point:: 99°C
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Liquid
pka: 11.17±0.29(Predicted)
color: Colorless to light yellow
InChI: InChI=1/C12H21N.ClH/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12;/h8-11H,2-7,13H2,1H3;1H/t8?,9-,10+,11-,12-;
InChIKey: OZBDFBJXRJWNAV-MZHJCFSPNA-N
SMILES: [C@]12(C[C@]3([H])C[C@@]([H])(C[C@@]([H])(C3)C1)C2)C(N)C.Cl |&1:0,2,5,8,r|
CAS DataBase Reference: 13392-28-4(CAS DataBase Reference)
NIST Chemistry Reference: 1-Adamantanemethylamine, «alpha»-methyl-(13392-28-4)

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Safety

HazardClass: IRRITANT
HS Code: 2902190000
Hazardous Substances Data: 13392-28-4(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: G879
Product name: Rimantadine
Packaging: 5g
Price: $298
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb134362
Product name: Rimantadine (Flumadine)
Purity: >99%
Packaging: 100mg
Price: $510
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0024288
Product name: RIMANTADINE
Purity: 95.00%
Packaging: 1G
Price: $648.81
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb134362
Product name: Rimantadine (Flumadine)
Purity: >99%
Packaging: 250mg
Price: $765
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0024288
Product name: RIMANTADINE
Purity: 95.00%
Packaging: 2.5G
Price: $852.21
Updated: 2021/12/16

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1-AdaMantanethylaMine Chemical Properties,Usage,Production

Description

Rimantadine (Brand name: Flumadine) is a kind of RNA synthesis inhibitor that used as an orally administrated antiviral drug in the prophylaxis and for the treatment of influenza. It is capable of shortening the duration and alleviated the symptoms of influenza. However, it is now not recommended for the treatment of influenza any longer due to the emergence of resistance problem since 2009. Its mechanism of action is not fully understood. It is indicated that it take effects through inhibiting the viral replication through possibly inhibiting the uncoating process of the virus. The virus M2 protein (an ion channel) seems to play an important role in the susceptibility of influenza A virus to the treatment of Rimantadine.

References

https://www.drugbank.ca/drugs/DB00478
https://en.wikipedia.org/wiki/Rimantadine

Uses

Rimantadine act by blocking the M2 ion channel which is required for uptake of protons into the interior of the virus to permit acid-promoted viral uncoating (decapsidation).

Definition

ChEBI: 1-(1-adamantyl)ethanamine is an alkylamine.

brand name

Flumadine (Forest).

General Description

Resistant variants of influenza type A have been recoveredfrom rimantadine-treated patients.Resistance with inhibitory concentrations increased morethan 100-fold have been associated with single nucleotidechanges that lead to amino acid substitutions in the transmembranedomain of M2. rimantadineshare cross-susceptibility and resistance.

Pharmaceutical Applications

An analog of amantadine, supplied as the hydrochloride for oral administration.

Mechanism of action

Rimantadine hydrochloride (α-methyl-1-adamantanemethylamine hydrochloride) is a synthetic adamatane derivative that is structurally and pharmacologically related to amantadine. It appears to be more effective than amantadine hydrochloride against influenza A, with fewer CNS side effects. Rimantadine hydrochloride is thought to interfere with virus uncoating by inhibiting the release of specific proteins. It may act by inhibiting RT or the synthesis of virus-specific RNA, but it does not inhibit virus adsorption or penetration. It appears to produce a virustatic effect early in the virus replication. It is used widely in Russia and Europe.

Pharmacokinetics

Oral absorption: >90%
C_max 100 mg oral (every 12 h): 0.4–0.5 mg/L after 2–6 h
Plasma half-life: c. 35 h
Volume of distribution: Very large
Plasma protein binding: c. 40%
Absorption and distribution
Single- and multiple-dose pharmacokinetic studies in elderly patients and young adults are remarkably similar. The steadystate concentration in nasal mucus develops by day 5 at a concentration approximately 1.5-fold higher than plasma.
Metabolism
In contrast to amantadine, rimantadine is extensively metabolized in the liver by hydroxylation and glucuronidation.
Excretion
Less than 20% is excreted unchanged in the urine and most of the breakdown products are excreted by this route. Thus, the plasma half-life is much less affected by renal dysfunction than that of amantadine.

Clinical Use

Prophylaxis and treatment of influenza A H1N1 infections Since prolonged administration is well tolerated by elderly patients, the drug is preferable to amantadine.

Clinical Use

rimantadine is used for the treatment of diseases caused by influenza A strains.

Side effects

Rimantadine has significantly fewer side effects than amantadine at equivalent doses, perhaps because of differences in pharmacokinetics, since with equal doses the blood levels are considerably lower. CNS side effects are not significantly higher than placebo.

1-AdaMantanethylaMine Preparation Products And Raw materials

Raw materials

Ethanol 1-Methylpiperazine Acetic acid Dimethyl sulfoxide L-Alaninol

Preparation Products

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1-AdaMantanethylaMine Suppliers

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View Lastest Price from 1-AdaMantanethylaMine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1-AdaMantanethylaMine 13392-28-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-19

Hebei Zhanyao Biotechnology Co. Ltd

Product: Rimantadine 13392-28-4
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-11-03

Qiuxian Baitai New Material Co., LTD

Product: Rimantadine 13392-28-4
Price: US $200.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500ton/Month
Release date: 2021-11-05

13392-28-4, 1-AdaMantanethylaMineRelated Search:

Amantadine Adamantane 1-Adamantaneacetic acid 1-Adamantanecarboxylic acid Ethylamine 1-(adamantan-1-yl)-2-methylpropan-1-amine hydrochloride Levofloxacin hydrochloride Methyldopa alpha-Methyldopa sesquihydrate Tricyclo[3.3.1.13,7]decane-1-methanamine, α-(1-methylethyl)- Rimantadine hydrochloride RIMANTADINE HCL USP(CRM STANDARD),RIMANTADINE-D4 HCL (ETHYL-D4) 98.5% 1-ADAMANTANEMETHYLAMINE 98%,1-Adamantanemethylamine Fluorine Levofloxacin Flunarizine Oxygen Hydrochloric acid Rimantadine

1-Adamantan-1-ylethylamine

1-Adamantanethylamine

Rimantadine & Rimantadine Hydrochloride

RiMantadine (FluMadine)

RiMantidine

1-(adaMantan-1-yl)ethanaMine hydrochloride

1-(AdaMantan-1-yl)ethanaMine

1-Adaman

1-ADAMANTANEMETHYLAMINE, alpha-METHYL-, HYDROCHLORIDE

Adamantane, 1-(1-aminoethyl)-, hydrochloride

Rimantadine hydrochloride [USAN]

Tricyclo(3.3.1.13,7)decane-1-methanamine, alpha-methyl-, hydrochloride (9CI)

α-Methyl-1-adamantanemethylamine

1-(1-Adamantyl)ethanamine

1-Adamantanemethylamine, alpha-methyl-

alpha-Methyl-1-adamantanemethylamine

alpha-Methyladamantanemethylamine

Tricyclo(3.3.1.1<sup>3,7</sup>)decane-1-methanamine, alpha-methyl-

Tricyclo[3,3,1,1(3,7)]decane-1-methanamine, alpha-methyl-

RIMANTADINE

1-(1-ADAMANTYL)ETHYLAMINE

AKOS NCG1-0034

AKOS B022266

LEVOFLOXACIN HCL

Levofloxacine Hydrochloride

Flunarizine hydrochloride cp2000,BP98

Rimantadine (base and/or unspecified salts)

1-Adamantanemethylamine

α-Methyl-1-adamantanemethanamine

(1R)-1-(1-adamantyl)ethanamine

1-Rimantadine

Tricyclo[3.3.1.13,7]decane-1-methanamine, α-methyl-

1-AdaMantanethylaMine USP/EP/BP

13392-28-4

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