alpha-Methyldopa sesquihydrate

Product Name: alpha-Methyldopa sesquihydrate
CAS No.: 41372-08-1
Chemical Name: alpha-Methyldopa sesquihydrate
Synonyms: (S)-2-AMINO-3-(3,4-DIHYDROXYPHENYL)-2-METHYLPROPIONIC ACID SESQUIHYDRATE;C07194;hyperpax;IDI1_000142;Prestwick2_;KBio3_001521;KBio2_006553;KBio2_003985;KBio2_001417;SPBio_001056
CBNumber: CB7135325
Molecular Formula: C10H15NO5
Formula Weight: 229.23
MOL File: 41372-08-1.mol

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alpha-Methyldopa sesquihydrate Property

Melting point:: >300 °C(lit.)
storage temp.: 2-8°C
solubility: Slightly soluble in water, very slightly soluble in ethanol (96 per cent). It is freely soluble in dilute mineral acids.
form: Solid
color: White to Off-White
optical activity: [α]25/D 13°, c = 1 in H2O
Water Solubility: 0.1-1 g/100 mL at 23 ºC
Sensitive: Air & Light Sensitive
Merck: 13,6080
BRN: 2417244
Stability:: Stable, but may be light sensitive. Very hygroscopic. Undergoes catalytic oxygenation in the presence of magnesium, cupric, cobalt, nickel and ferric ions. Store under a dry atmosphere.
CAS DataBase Reference: 41372-08-1(CAS DataBase Reference)

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Safety

Risk Statements: 20/21-36/37/38-42/43-65
Safety Statements: 24/25
WGK Germany: 3
RTECS: YP2860000
F: 10-23
HS Code: 2922504500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2672
Product name: Methyldopa
Purity: PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial
Packaging: 1G
Price: $334
Updated: 2024/03/01

Sigma-Aldrich

Product number: 857416
Product name: (?)-3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine sesquihydrate
Purity: 99%
Packaging: 5g
Price: $77.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1426002
Product name: Methyldopa
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 500mg
Price: $802
Updated: 2024/03/01

Alfa Aesar

Product number: H56704
Product name: (-)-3,4-Dihydroxy-alpha-methyl-L-phenylalanine sesquihydrate, 99%
Packaging: 1g
Price: $14.65
Updated: 2024/03/01

Alfa Aesar

Product number: H56704
Product name: (-)-3,4-Dihydroxy-alpha-methyl-L-phenylalanine sesquihydrate, 99%
Packaging: 5g
Price: $49.65
Updated: 2024/03/01

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alpha-Methyldopa sesquihydrate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Potent inhibitor of invertase and glucosidase inhibitor with a different specificity of action to DNJ and castanospermine. Inhibits glucosidase I.

Uses

Antihypertensive agent.

Biological Activity

l-(-)-α-methyldopa (hydrate) is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.

Purification Methods

Recrystallise methyldopa from H2O. [Reinhold et al. J Org Chem 33 1209 1968.] The L-isomer forms a sesquihydrate from H2O m 302-304o (dec), and the anhydrous crystals are hygroscopic,[] 23D -4.0o (c 1, 0.1N HCl), []546 +154.5o (c 5, CuSO4 solution). It has max at 281nm ( 2780). Its solubility in H2O at 25o is ~10mg/mL and the pH of an aqueous solution is ~5.0. It is insoluble in most organic solvents. [Stein et al. J Am Chem Soc 77 700 1955, Beilstein 4 IV 2505.]

alpha-Methyldopa sesquihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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alpha-Methyldopa sesquihydrate Suppliers

Belgium 1 Brazil 1 Canada 2 China 219 Europe 2 Germany 5 India 10 Israel 1 Japan 1 Singapore 1 South Korea 1 Switzerland 2 The Netherlands 1 United Kingdom 9 United States 34 Global 290

Sinfachem Limited

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J & K SCIENTIFIC LTD.

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Shanghai Hanhong Scientific Co.,Ltd.

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Chemsky（shanghai）International Co.,Ltd.

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XiaoGan ShenYuan ChemPharm co,ltd

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View Lastest Price from alpha-Methyldopa sesquihydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: L-Methyldopa 41372-08-1
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%-102%;USP
Supply Ability: 100KGS
Release date: 2021-07-19

Hebei Weibang Biotechnology Co., Ltd

Product: alpha-Methyldopa sesquihydrate 41372-08-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-30

Hebei Zhanyao Biotechnology Co. Ltd

Product: Alpha-Methyldopa Sesquihydrate 41372-08-1
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-11-15

41372-08-1, alpha-Methyldopa sesquihydrateRelated Search:

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2-methyl-3-(3,4-Dihydroxyphenyl)-L-alanine sesquihydrate

(-)-3,4-Dihydroxy-alpha-methyl-L-phenylalanine sesquihydrate

à-methyl-l-dopa

L-(-)-ALPHA-METHYLDOPA ((-)-3-(3,4-DIHYDROXYPHENYL)-2-METHYL-L-ALANINE SESQUIHYDRATE)

L-TYROSINE, 3-HYDROXY-.ALPHA.-METHYL-, HYDRATE

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(-)-Methyldopa Hydrate

(S)-a-Methyldopa Hydrate

3-Hydroxy-a-methyl-L-tyrosine Hydrate

a-Methyl-L-3,4-dihydroxyphenylalanine Hydrate

L-a-Methyl DOPA Hydrate

α-Methyl-L-DOPA, L-α-Methyl-DOPA

3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine, Methyl-L-DOPA, MK-351

**DISCONTINUED**

L-α-Methyl DOPA Hydrate

()-3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine sesquihydrate,α-Methyl-L-DOPA, L-α-Methyl-DOPA

Methyldopa (500 mg)

3-Hydroxy-alpha-methyl-L-tyrosine hydrate

alpha-Methyldopa ses

L-Methyldopa USP

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2-amino-3-(3,4-dihydroxyphenyl)butanoic acid hydrate

3-hydroxy-alpha-methyl-l-tyrosinhydrate(2:3)

hyperpax

(S)-2-AMINO-3-(3,4-DIHYDROXYPHENYL)-2-METHYLPROPIONIC ACID SESQUIHYDRATE

(-)-ALPHA-METHYL-L-DOPA SESQUIHYDRATE

ALPHA-METHYL-L-DOPA SESQUIHYDRATE

ALPHA-METHYL-DOPA SESQUIHYDRATE

(-)-3-(3,4-DIHYDROXYPHENYL)-2-METHYL-L-ALANINE SESQUIHYDRATE

3-(3,4-DIHYDROXYPHENYL)-2-METHYL-L-ALANINE SESQUIHYDRATE

methyl dopa sesquihydrate

L-METHYL DOPA USP24

L-Methyldopa sesquihydrate

3-(3,4-DIHYDROXYPHENYL)-2-METHYL-

MethyldopaUsp25

(-)-3-(3,4-Dihydroxyphenyl)-2-methyl-L-alaninesesquihydrate,99%

3-HYDROXY-ALPHA-METHYL-L-TYROSINE SESQUIHYDRATE

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