ChemicalBook > CAS DataBase List > alpha-Methyldopa sesquihydrate

alpha-Methyldopa sesquihydrate

Product Name
alpha-Methyldopa sesquihydrate
CAS No.
41372-08-1
Chemical Name
alpha-Methyldopa sesquihydrate
Synonyms
(S)-2-AMINO-3-(3,4-DIHYDROXYPHENYL)-2-METHYLPROPIONIC ACID SESQUIHYDRATE;C07194;hyperpax;IDI1_000142;Prestwick2_;KBio3_001521;KBio2_006553;KBio2_003985;KBio2_001417;SPBio_001056
CBNumber
CB7135325
Molecular Formula
C10H15NO5
Formula Weight
229.23
MOL File
41372-08-1.mol
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alpha-Methyldopa sesquihydrate Property

Melting point:
>300 °C(lit.)
storage temp. 
2-8°C
solubility 
Slightly soluble in water, very slightly soluble in ethanol (96 per cent). It is freely soluble in dilute mineral acids.
color 
White to Off-White
optical activity
[α]25/D 13°, c = 1 in H2O
Water Solubility 
0.1-1 g/100 mL at 23 ºC
Sensitive 
Air & Light Sensitive
Merck 
13,6080
BRN 
2417244
Stability:
Stable, but may be light sensitive. Very hygroscopic. Undergoes catalytic oxygenation in the presence of magnesium, cupric, cobalt, nickel and ferric ions. Store under a dry atmosphere.
CAS DataBase Reference
41372-08-1(CAS DataBase Reference)
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Safety

Risk Statements 
20/21-36/37/38-42/43-65
Safety Statements 
24/25
WGK Germany 
3
RTECS 
YP2860000
F 
10-23
HS Code 
2922504500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2672
Product name
Methyldopa
Purity
PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial
Packaging
1G
Price
$334
Updated
2024/03/01
Sigma-Aldrich
Product number
857416
Product name
(?)-3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine sesquihydrate
Purity
99%
Packaging
5g
Price
$77.2
Updated
2024/03/01
Sigma-Aldrich
Product number
1426002
Product name
Methyldopa
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$802
Updated
2024/03/01
Alfa Aesar
Product number
H56704
Product name
(-)-3,4-Dihydroxy-alpha-methyl-L-phenylalanine sesquihydrate, 99%
Packaging
1g
Price
$14.65
Updated
2024/03/01
Alfa Aesar
Product number
H56704
Product name
(-)-3,4-Dihydroxy-alpha-methyl-L-phenylalanine sesquihydrate, 99%
Packaging
5g
Price
$49.65
Updated
2024/03/01
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alpha-Methyldopa sesquihydrate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Potent inhibitor of invertase and glucosidase inhibitor with a different specificity of action to DNJ and castanospermine. Inhibits glucosidase I.

Uses

Antihypertensive agent.

Biological Activity

l-(-)-α-methyldopa (hydrate) is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.

Purification Methods

Recrystallise methyldopa from H2O. [Reinhold et al. J Org Chem 33 1209 1968.] The L-isomer forms a sesquihydrate from H2O m 302-304o (dec), and the anhydrous crystals are hygroscopic,[] 23D -4.0o (c 1, 0.1N HCl), []546 +154.5o (c 5, CuSO4 solution). It has max at 281nm ( 2780). Its solubility in H2O at 25o is ~10mg/mL and the pH of an aqueous solution is ~5.0. It is insoluble in most organic solvents. [Stein et al. J Am Chem Soc 77 700 1955, Beilstein 4 IV 2505.]

alpha-Methyldopa sesquihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from alpha-Methyldopa sesquihydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
L-Methyldopa 41372-08-1
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%-102%;USP
Supply Ability
100KGS
Release date
2021-07-19
Hebei Guanlang Biotechnology Co., Ltd.
Product
alpha-Methyldopa sesquihydrate 41372-08-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2022-11-18
Hebei Zhanyao Biotechnology Co. Ltd
Product
Alpha-Methyldopa Sesquihydrate 41372-08-1
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-15

41372-08-1, alpha-Methyldopa sesquihydrateRelated Search:

Kresoxim-methyl TYROSINASE CHLOROPHOSPHONAZO III Chloral hydrate Boc-D-Tyr-OH Methyl acrylate H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH Bensulfuron methyl Methyldopa Methylparaben Methyl acetate Thiophanate-methyl Diethylstilbestrol L-Tyrosine 1-AdaMantanethylaMine Methyl Parathion-methyl S-(-)-Carbidopa

  • (-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate 99%
  • BPBio1_000365
  • BSPBio_000331
  • C07194
  • IDI1_000142
  • KBio2_001417
  • KBio2_003985
  • KBio2_006553
  • KBio3_001521
  • KBioGR_000547
  • Lopac0_000853
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  • NCGC00024667-04
  • Prestwick0_000326
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  • SPBio_001056
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  • 2-methyl-3-(3,4-Dihydroxyphenyl)-L-alanine sesquihydrate
  • (-)-3,4-Dihydroxy-alpha-methyl-L-phenylalanine sesquihydrate
  • à-methyl-l-dopa
  • L-(-)-ALPHA-METHYLDOPA ((-)-3-(3,4-DIHYDROXYPHENYL)-2-METHYL-L-ALANINE SESQUIHYDRATE)
  • L-TYROSINE, 3-HYDROXY-.ALPHA.-METHYL-, HYDRATE
  • (-)-a-Methyldopa Hydrate
  • (-)-Methyldopa Hydrate
  • (S)-a-Methyldopa Hydrate
  • 3-Hydroxy-a-methyl-L-tyrosine Hydrate
  • a-Methyl-L-3,4-dihydroxyphenylalanine Hydrate
  • L-a-Methyl DOPA Hydrate
  • α-Methyl-L-DOPA, L-α-Methyl-DOPA
  • 3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine, Methyl-L-DOPA, MK-351
  • **DISCONTINUED**
  • L-α-Methyl DOPA Hydrate
  • ()-3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine sesquihydrate,α-Methyl-L-DOPA, L-α-Methyl-DOPA
  • Methyldopa (500 mg)
  • 3-Hydroxy-alpha-methyl-L-tyrosine hydrate
  • alpha-Methyldopa ses
  • L-Methyldopa USP
  • L-Tyrosine, 3-hydroxy-a-methyl-, hydrate (2:3)
  • 2-amino-3-(3,4-dihydroxyphenyl)butanoic acid hydrate
  • 3-hydroxy-alpha-methyl-l-tyrosinhydrate(2:3)
  • hyperpax
  • (S)-2-AMINO-3-(3,4-DIHYDROXYPHENYL)-2-METHYLPROPIONIC ACID SESQUIHYDRATE
  • (-)-ALPHA-METHYL-L-DOPA SESQUIHYDRATE
  • ALPHA-METHYL-L-DOPA SESQUIHYDRATE
  • ALPHA-METHYL-DOPA SESQUIHYDRATE
  • (-)-3-(3,4-DIHYDROXYPHENYL)-2-METHYL-L-ALANINE SESQUIHYDRATE
  • 3-(3,4-DIHYDROXYPHENYL)-2-METHYL-L-ALANINE SESQUIHYDRATE
  • methyl dopa sesquihydrate
  • L-METHYL DOPA USP24
  • L-Methyldopa sesquihydrate
  • 3-(3,4-DIHYDROXYPHENYL)-2-METHYL-
  • MethyldopaUsp25
  • (-)-3-(3,4-Dihydroxyphenyl)-2-methyl-L-alaninesesquihydrate,99%
  • 3-HYDROXY-ALPHA-METHYL-L-TYROSINE SESQUIHYDRATE
  • 3-hydroxy-b-methyl-l-tyrosine hydrate
  • -METHYL-L-DOPA SESQUIHYDRATE