Rimantadine hydrochloride

Product Name: Rimantadine hydrochloride
CAS No.: 1501-84-4
Chemical Name: Rimantadine hydrochloride
Synonyms: FLUMADINE;RIMANTADINE HCL;1-(1-ADAMANTYL)ETHYLAMINE HYDROCHLORIDE;1-(1-AdaMantyl)ethylaMine hydrochloride 99%;jp61;exp126;ROFLUAL;meradan;MERADANE;FlumMine
CBNumber: CB1270657
Molecular Formula: C12H21N.ClH
Formula Weight: 215.76
MOL File: 1501-84-4.mol

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Rimantadine hydrochloride Property

Melting point:: >300 °C(lit.)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly), Water(Slightly)
form: Solid
color: White to Off-White
Water Solubility: Freely soluble in water.
Merck: 14,8224
InChI: InChI=1S/C12H21N.ClH/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12;/h8-11H,2-7,13H2,1H3;1H
InChIKey: OZBDFBJXRJWNAV-UHFFFAOYSA-N
SMILES: C1C2CC3(C(N)C)CC1CC(C3)C2.Cl
CAS DataBase Reference: 1501-84-4

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: AU4717000
HS Code: 29213000
Toxicity: LD50 oral in rat: 640mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR3267
Product name: Rimantadine Hydrochloride
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 500mg
Price: $178
Updated: 2025/07/31

Sigma-Aldrich

Product number: 390593
Product name: 1-(1-Adamantyl)ethylamine hydrochloride
Purity: 99%
Packaging: 1g
Price: $59.56
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1604508
Product name: Rimantadine hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 300mg
Price: $425
Updated: 2025/07/31

TCI Chemical

Product number: R0070
Product name: 1-(1-Adamantyl)ethylamine Hydrochloride
Purity: >98.0%(N)
Packaging: 5g
Price: $61
Updated: 2025/07/31

Cayman Chemical

Product number: 23838
Product name: Rimantadine (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $32
Updated: 2024/03/01

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Rimantadine hydrochloride Chemical Properties,Usage,Production

Description

Rimantadine hydrochloride is an antiviral analogue of amantadine, reportedly useful in the prophylaxis and treatment of influenza A. Compared with amantadine, nmantadine appears to have a lower side-effect profile.

Chemical Properties

White Crystalline Solid

Originator

DuPont (USA)

Uses

Rimantadine Hydrochloride is used as an antiviral agent.

Definition

ChEBI: Rimantadine hydrochloride is an organic molecular entity.

brand name

Flumadine (Forest);Roflual.

Synthesis

78679-71-7

1501-84-4

Example 3: To a Parr hydrogenation flask was added 13.7 g of 1-adamantyl methyl ketoxime (CAS: 78679-71-7), 4.0 g of 5% Pt/C catalyst and 200 ml of glacial acetic acid. After displacing the air in the flask with hydrogen, the hydrogenation reaction was carried out at 30-35 psia (200-240 KPa) hydrogen pressure for 2.25 h at room temperature. After the hydrogen absorption ceased, the reaction mixture was left to stand overnight. Subsequently, the catalyst was filtered off and the acetic acid solution was concentrated to about one-third of the original volume by distillation under reduced pressure. To the concentrated solution, 150 ml of water was added and the pH was adjusted to alkaline with sodium hydroxide solution to obtain an emulsion mixture. The emulsion was extracted twice with 100 ml of dichloromethane. The organic phases were combined, dried with magnesium sulfate and filtered. Hydrogen chloride gas was passed into the clarified dichloromethane solution and a white solid was precipitated. Next, 100 ml of ethyl acetate was added to induce the precipitation of more solids. The solid was collected by filtration to give 11.4 g of amantadine hydrochloride in 75% yield.

References

[1] koff w c, elm jr j l, halstead s b. suppression of dengue virus replication in vitro by rimantadine hydrochloride[j]. the american journal of tropical medicine and hygiene, 1981, 30(1): 184-189.
[2] koff w c, peavy d l, knight v. inhibition of in vitro proliferative responses of human lymphocytes by rimantadine hydrochloride[j]. infection and immunity, 1979, 23(3): 665-669.
[3] hayden f g, monto a s. oral rimantadine hydrochloride therapy of influenza a virus h3n2 subtype infection in adults[j]. antimicrobial agents and chemotherapy, 1986, 29(2): 339-341.

Rimantadine hydrochloride Preparation Products And Raw materials

Raw materials

Adamantane RIMANTADINE HCL USP(CRM STANDARD) Vinyl bromide Mercuric Oxide Lithium Aluminum Hydride

Preparation Products

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Rimantadine hydrochloride Suppliers

Belgium 2 Brazil 2 Canada 5 China 321 Estonia 1 Europe 2 France 2 Germany 4 India 9 Japan 4 Latvia 1 Russia 1 South Korea 1 Switzerland 4 Turkey 1 Ukraine 1 United Kingdom 17 United States 36 Global 414

Zhejiang Apeloa Pharmaceutical Co. Ltd.

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Country: China
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Sichuan Zhongbang Pharma CO.，LTD

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Email: sales2@zhongbangst.com
Country: China
ProdList: 105
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Hangzhou Bingochem Co., Ltd.

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Country: China
ProdList: 21669
Advantage: 58

J & K SCIENTIFIC LTD.

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Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

INTATRADE GmbH

Tel: +49 3493/605464
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Country: Germany
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3B Pharmachem (Wuhan) International Co.,Ltd.

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Fax: 86-21-50328109
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Country: China
ProdList: 15838
Advantage: 69

Chembest Research Laboratories Limited

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Email: sales@BioChemBest.com
Country: China
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Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

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View Lastest Price from Rimantadine hydrochloride manufacturers

Dideu Industries Group Limited

Product: Rimantadine hydrochloride 1501-84-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% Min
Supply Ability: 100 Tons Min
Release date: 2025-09-19

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Rimantadine hydrochloride 1501-84-4
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%-101%
Supply Ability: 500KGS
Release date: 2021-07-15

Hebei Chuanghai Biotechnology Co., Ltd

Product: Rimantadine hydrochloride 1501-84-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-05

1501-84-4, Rimantadine hydrochlorideRelated Search:

Adamantane 2-Chloroethylamine hydrochloride Topotecan hydrochloride Triethylamine hydrochloride 1-AdaMantanethylaMine Ethambutol dihydrochloride Ethylamine hydrochloride 2-(2-Aminoethylamino)ethanol Amantadine Acetaminophen Pentoxyverine Granisetron Hydrochloride 1-Adamantanamine hydrochloride Cefixime 1-BROMO-3-METHYLADAMANTANE 1-METHYLADAMANTANE N-ADAMANTAN-1-YL-2-CHLORO-ACETAMIDE N-Acetyl DeMethyl MeMantine

FLUMADINE

IFLAB-BB F1386-0449

MERADANE

1-(1-aminoethyl)adamantane hydrochloride

1-(1-ADAMANTYL)ETHANAMINE HYDROCHLORIDE

1-(1-ADAMANTYL)ETHYLAMINE HYDROCHLORIDE

ALPHA-METHYL-1-ADAMANTANEMETHYLAMINE HYDROCHLORIDE

ROFLUAL

RIMANTADINE HCL

RIMANTADINE HYDROCHLORIDE

TIMTEC-BB SBB003389

1-(1-aminoethyl)-adamantanhydrochloride

7))decane-1-methanamine,alpha-methyl-tricyclo(3.3.1.1(suphydrochloride

alpha-methyl-1-adamantanemethylaminhydrochloride

1-(Adamantan-1-yl)ethylamine hydrochloride, Rimantadine hydrochloride

α-Methyltricyclo[3.3.1.13,7]decane-1-methanamine Hydrochloride

a-Methyltricyclo[3.3.1.13,7]decane-1-methanamine Hydrochloride

Tricyclo[3.3.1.1<sup>3,7</sup>]decane-1-MethanaMine,a-Methyl-, hydrochloride (1:1)

α-Methyltricyclo[3.3.1.13,7]decane-1-MethanaMine

alpha-Methyl-1-adamantanemethylamine Hydrochloride Rimantadine Hydrochloride

RiMantadine hydrochloride(FluMadine)

FlumMine

Remantadin(e)Hydrochloride

α-Methyl-1-adaman-tanemethylamine hydrochloride

Remantadine

1-(1-Adamanty)ethylamine Hydrochloride

Rimantadine Hydrochloride (300 mg)

alpha-methyltricyclo(3.3.1.1(sup3,7))decane-1-methanaminehydrochloride

exp126

jp61

meradan

remantadin

Flumadine, Meradane, Roflual

RAMANTADINE HYDROCHLORIDE

1-(1-ADAMANTYL)ETHYLAMINE HYDROCHLORIDE 98+%

1-(1-AdaMantyl)ethylaMine hydrochloride 99%

Rimantadine hydrochloride Synonyms Flumadine

1-(1-adamantyl)ethylamine hcl

1-(1-Adamantyl)ethylamine hydrochlor

Rimantadine hydrochloride solution,100ppm

Adamantyl Hydrochloride

1-(1-Adamantyl)ethylamine Hydrochloride &gt

Tricyclo[3.3.1.13,7]decane-1-methanamine, α-methyl-, hydrochloride (1:1)

Rimantadine hydrochloride USP/EP/BP

RIMANTADINE HCL USP(CRM STANDARD) USP/EP/BP

Rimantadine HydrochlorideQ: What is Rimantadine Hydrochloride Q: What is the CAS Number of Rimantadine Hydrochloride Q: What is the storage condition of Rimantadine Hydrochloride Q: What are the applications of Rimantadine Hydrochloride

Rimantadine Hydrochloride (1604508)

Mifepristone Impurity 12

Rimantadine HCl in Methanol

Rimantadine hydrochloride, 10 mM in DMSO

Rimantadine HCl - Bio-X ?

1501-84-4

156-2-80

C12H21NHCl

C12H22ClN

C12H21NClH

C12H21NHClC12H22ClN

Adamantanes