2-Fluoro-3-nitropyridine
- Product Name
- 2-Fluoro-3-nitropyridine
- CAS No.
- 1480-87-1
- Chemical Name
- 2-Fluoro-3-nitropyridine
- Synonyms
- uoro-3-nitropyridine;2-Fluoro-3-nitropyri;2-FLUORO-3-NITROPYRIDINE;2-Fluoro-3-nitrylpyridine;2-Fluoro-3-nitropyridine>Pyridine, 2-fluoro-3-nitro-;2-Fluoro-3-nitropyridine,98%;2-Fluoro-3-nitropyridine, 97+%;3-bromo-2-fluoro-5-trifluoromethyl ryridine;2-Fluoro-3-nitropyridine ISO 9001：2015 REACH
- CBNumber
- CB0427546
- Molecular Formula
- C5H3FN2O2
- Formula Weight
- 142.09
- MOL File
- 1480-87-1.mol
2-Fluoro-3-nitropyridine Property
- Melting point:
- 18℃
- Boiling point:
- 110℃/10mm
- Density
- 1.439±0.06 g/cm3(Predicted)
- refractive index
- 1.5300 to 1.5340
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Low Melting Solid
- pka
- -4.47±0.10(Predicted)
- color
- Yellow
- Water Solubility
- Slightly soluble in water.
- CAS DataBase Reference
- 1480-87-1(CAS DataBase Reference)
Safety
- Hazard Codes
- T,Xi,C
- Risk Statements
- 20/21/22-36/37/38-34
- Safety Statements
- 26-36/37/39-45
- Hazard Note
- Toxic
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F0982
- Product name
- 2-Fluoro-3-nitropyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $50
- Updated
- 2025/07/31
- Product number
- F0982
- Product name
- 2-Fluoro-3-nitropyridine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $169
- Updated
- 2025/07/31
- Product number
- F597680
- Product name
- 2-Fluoro-3-nitropyridine
- Packaging
- 2.5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 033250
- Product name
- 2-Fluoro-3-nitropyridine
- Packaging
- 25g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CS-D0967
- Product name
- 2-Fluoro-3-nitropyridine
- Purity
- 99.85%
- Packaging
- 100g
- Price
- $200
- Updated
- 2021/12/16
2-Fluoro-3-nitropyridine Chemical Properties,Usage,Production
Uses
2-Fluoro-3-nitropyridine is used as a pharmaceutical intermediate.
Synthesis
5470-18-8
1480-87-1
General procedure for the synthesis of 2-fluoro-3-nitropyridine from 2-chloro-3-nitropyridine: 2-chloro-3-nitropyridine (1.00 g, 6.76 mmol) was dissolved in DMSO (33.8 ml) at room temperature, followed by addition of CsF (2.053 g, 13.51 mmol). The reaction mixture was stirred in air at 110°C for 20 hrs. After completion of the reaction, the reaction mixture was quenched with ice water and extracted with EtOAc. The organic layer was separated, washed sequentially with water and brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. Purification of the residue by column chromatography (silica gel as stationary phase and EtOAc/hexane as eluent) afforded 2-fluoro-3-nitropyridine (0.639 g, 4.86 mmol, 71.9% yield) as a colorless oil. Similarly, compounds 3B'-8B' can be prepared according to the synthesis of 2B' above.
References
[1] European Journal of Inorganic Chemistry, 2017, vol. 2017, # 2, p. 330 - 339
[2] Tetrahedron Letters, 2015, vol. 56, # 44, p. 6043 - 6046
[3] Heterocycles, 1986, vol. 24, # 11, p. 3213 - 3221
[4] Journal of Labelled Compounds and Radiopharmaceuticals, 2004, vol. 47, # 6, p. 373 - 383
[5] Tetrahedron, 2001, vol. 57, # 4, p. 739 - 750
2-Fluoro-3-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoro-3-nitropyridine manufacturers
- Product
- 2-Fluoro-3-nitropyridine 1480-87-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-30
- Product
- 2-Fluoro-3-nitropyridine 1480-87-1
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-11
- Product
- 2-Fluoro-3-nitropyridine 1480-87-1
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08