2-Fluoro-3-hydroxypyridine

Product Name: 2-Fluoro-3-hydroxypyridine
CAS No.: 174669-74-0
Chemical Name: 2-Fluoro-3-hydroxypyridine
Synonyms: 2-Fluoropyridin-3-ol;CAS:174669-74-0;2-Fluoro-3-pyridinol;2-Fluoro-3-hydroxypy;2-FLUOROPYRIDINE-3-OL;3-Pyridinol, 2-fluoro-;2-Fluoro-3-hydroxytyrosine;3-FLUORO-2-HYDROXYPYRIDINE;3-fluoro-2-hdyroxypyridine;2-FLUORO-3-HYDROXYPYRIDINE
CBNumber: CB5367690
Molecular Formula: C5H4FNO
Formula Weight: 113.09
MOL File: 174669-74-0.mol

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2-Fluoro-3-hydroxypyridine Property

Melting point:: 131-133°C
Boiling point:: 306.7±22.0 °C(Predicted)
Density: 1.325±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO, Methanol
pka: 4.92±0.10(Predicted)
form: Solid
color: Pale Yellow
CAS DataBase Reference: 174669-74-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-37
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: F0886
Product name: 2-Fluoro-3-hydroxypyridine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $130
Updated: 2025/07/31

TCI Chemical

Product number: F0886
Product name: 2-Fluoro-3-hydroxypyridine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $440
Updated: 2025/07/31

TRC

Product number: F591920
Product name: 2-Fluoro-3-hydroxypyridine
Packaging: 10g
Price: $690
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H01-3-08
Product name: 2-Fluoro-3-hydroxypyridine
Packaging: 100g
Price: $464
Updated: 2021/12/16

Apolloscientific

Product number: PC01476
Product name: 2-Fluoro-3-hydroxypyridine
Packaging: 100g
Price: $290
Updated: 2021/12/16

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2-Fluoro-3-hydroxypyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow Cryst

Uses

A pyridine derivative used in the preparation of imaging agents for nicotinic α4β2 receptor.

Uses

As a pyridine derivative, 2-Fluoro-3-hydroxypyridine can be used in the preparation of imaging agents for nicotinic α4β2 receptor.

Synthesis

16867-03-1

174669-74-0

100 mL of pyridine hydrofluoride (Py-(HF)x, 70% hydrogen fluoride and 30% pyridine, purchased from Fluka) was cooled at 0°C. 3.7 g of 2-amino-3-hydroxypyridine (molecular weight: 110.12, 33.6 mmol) and 3 g of NaNO2 (molecular weight: 69.00, 43.5 mmol) were added to it in sequence, handling with caution. The reaction mixture was stirred at 0 °C for 1 h, followed by slow alkalinization with 10 N NaOH aqueous solution. The mixture was transferred to a partition funnel and extracted with EtOAc. The organic phases were combined, washed sequentially with water and brine, dried over Na2SO4 and concentrated to dryness. The residue was purified by silica gel column chromatography (eluent: heptane/EtOAc, 50/50) to give 2.5 g (65% yield) of solid 2-fluoro-3-hydroxypyridine, which did not require further purification. Thin layer chromatography (TLC) Rf value (EtOAc/heptane, 80/20): 0.65. melting point: 131 °C. 1H NMR (DMSO-d6, 298 K): δ 10.41 (s, 1H), 7.64 (td, J=1.7 and 4.7 Hz, 1H), 7.42 (dd, J=1.7,1.7 and 10.8 Hz, 1H). 7.17 (ddd, J=1.3,4.7 and 7.8 Hz, 1H).13C NMR (DMSO-d6, 298K): δ 152.8 (d, J1F-C=233 Hz, C), 140.2 (d, J2F-C=27 Hz, C), 135.6 (d, J3F-C=13 Hz, CH), 126.2 (d, J3F -C=5 Hz, CH), 122.6 (CH). Mass spectrum (DCI/NH4+): C5H4FNO: 131 [M+NH4+], 114 [M+H+]. Elemental analysis (C5H4FNO) is consistent with theoretical values for C, H, and N.

References

[1] Patent: US2005/249662, 2005, A1. Location in patent: Page/Page column 8-9
[2] Journal of Labelled Compounds and Radiopharmaceuticals, 1998, vol. 41, # 5, p. 451 - 463
[3] Journal of Labelled Compounds and Radiopharmaceuticals, 2008, vol. 51, # 9, p. 336 - 342
[4] Patent: US2010/29650, 2010, A1. Location in patent: Page/Page column 64
[5] Organic and Biomolecular Chemistry, 2015, vol. 13, # 12, p. 3667 - 3676

2-Fluoro-3-hydroxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-3-hydroxypyridine Suppliers

Americas 1 Belgium 1 Canada 2 China 172 Europe 4 France 4 Germany 8 India 12 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 9 United States 40 Global 256

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View Lastest Price from 2-Fluoro-3-hydroxypyridine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Fluoro-3-hydroxypyridine 174669-74-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

Dideu Industries Group Limited

Product: 2-Fluoro-3-hydroxypyridine 174669-74-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-24

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Fluoro-3-hydroxypyridine 174669-74-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

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2-Fluoro-3-hydroxypyridine97%

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2-Fluoropyridin-3-ol

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2-Fluoro-3-hydroxypy

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2-Fluoro-3-hydroxypyridine ISO 9001：2015 REACH

CAS:174669-74-0

174669-74-0

Fluorine series

Pyridines

Boronic Acid

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

HALIDE

PYRIDINE