6-Bromo-2-fluoro-3-hydroxypyridine
- Product Name
- 6-Bromo-2-fluoro-3-hydroxypyridine
- CAS No.
- 850142-72-2
- Chemical Name
- 6-Bromo-2-fluoro-3-hydroxypyridine
- Synonyms
- 6-Bromo-2-fluoro-3-pyridinol;3-Pyridinol, 6-bromo-2-fluoro-;6-Bromo-2-fluoro-3-hydroxypyridine
- CBNumber
- CB01471302
- Molecular Formula
- C5H3BrFNO
- Formula Weight
- 191.99
- MOL File
- 850142-72-2.mol
6-Bromo-2-fluoro-3-hydroxypyridine Property
- Boiling point:
- 355.0±37.0 °C(Predicted)
- Density
- 1.891±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 4.46±0.10(Predicted)
- Appearance
- White to light yellow Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B961663
- Product name
- 6-Bromo-2-fluoropyridin-3-ol
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB81973
- Product name
- 6-Bromo-2-Fluoro-3-Hydroxypyridine
- Packaging
- 100mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FB81973
- Product name
- 6-Bromo-2-Fluoro-3-Hydroxypyridine
- Packaging
- 250mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FB81973
- Product name
- 6-Bromo-2-Fluoro-3-Hydroxypyridine
- Packaging
- 500mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- PC910235
- Product name
- 6-Bromo-2-fluoropyridin-3-ol
- Purity
- 95%
- Packaging
- 1g
- Price
- $370
- Updated
- 2021/12/16
6-Bromo-2-fluoro-3-hydroxypyridine Chemical Properties,Usage,Production
Synthesis
174669-74-0
850142-72-2
General procedure for the synthesis of 6-bromo-2-fluoro-3-pyridinol from 2-fluoro-3-hydroxypyridine: Bromine (1.56 g, 9.73 mmol) was slowly added to a stirred solution of 2-fluoro-3-hydroxypyridine (1.10 g, 9.73 mmol) and sodium acetate (0.80 g, 9.73 mmol) in acetic acid (10 mL) at 5 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 4 hours at room temperature. Upon completion of the reaction, the mixture was poured into ice water and neutralized with 2N sodium hydroxide solution to a pH of about 7, followed by extraction with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate, and the filtrate was concentrated by filtration to give a yellow oily crude product. The crude product was purified by rapid chromatography on a silica gel column with an eluent of 1:20 ethyl acetate/dichloromethane to give a colorless oil, which solidified to a white solid after standing. The solid was recrystallized with hexane to give 0.2 g (11% yield) of 6-bromo-2-fluoro-3-pyridinol. The solid obtained by concentrating the filtrate was recrystallized with 2:1 hexane/benzene to give another 0.57 g (31% yield) of 6-bromo-2-fluoro-3-pyridinol. The product was characterized by 1H NMR (400 MHz, DMSO-d6) and LRMS (ESI): 1H NMR δ 10.77 (s, 1H), 7.40-7.30 (m, 2H); LRMS m/z 192/194 (M + H).
References
[1] Patent: WO2005/35522, 2005, A1. Location in patent: Page/Page column 74
[2] Patent: WO2005/35523, 2005, A1. Location in patent: Page/Page column 42-43
[3] Patent: WO2017/91818, 2017, A1. Location in patent: Page/Page column 176
[4] Patent: US2010/29650, 2010, A1. Location in patent: Page/Page column 64
[5] Patent: WO2015/48507, 2015, A1. Location in patent: Paragraph 0175
6-Bromo-2-fluoro-3-hydroxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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