Methyl 6-broMo-2-Methoxynicotinate

Product Name: Methyl 6-broMo-2-Methoxynicotinate
CAS No.: 1009735-24-3
Chemical Name: Methyl 6-broMo-2-Methoxynicotinate
Synonyms: Methyl 6-broMo-2-Methoxynicotinate;6-bromo-2-methoxynicotinic acid methyl ester;methyl 6-bromo-2-methoxy-pyridine-3-carboxylate;3-Pyridinecarboxylic acid, 6-bromo-2-methoxy-, methyl ester
CBNumber: CB42732963
Molecular Formula: C8H8BrNO3
Formula Weight: 246.06
MOL File: 1009735-24-3.mol

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Methyl 6-broMo-2-Methoxynicotinate Property

Boiling point:: 296.5±35.0 °C(Predicted)
Density: 1.530±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.08±0.10(Predicted)
Appearance: White to light yellow Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 2759DV
Product name: Methyl6-bromo-2-methoxynicotinate
Packaging: 250mg
Price: $288
Updated: 2021/12/16

AK Scientific

Product number: 2759DV
Product name: Methyl6-bromo-2-methoxynicotinate
Packaging: 5g
Price: $1724
Updated: 2021/12/16

AK Scientific

Product number: 2759DV
Product name: Methyl6-bromo-2-methoxynicotinate
Packaging: 10g
Price: $2548
Updated: 2021/12/16

Alichem

Product number: 1009735243
Product name: Methyl6-bromo-2-methoxynicotinate
Packaging: 5g
Price: $1824.47
Updated: 2021/12/16

Ambeed

Product number: A378813
Product name: Methyl6-bromo-2-methoxynicotinate
Purity: 98%
Packaging: 10g
Price: $1843
Updated: 2021/12/16

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Methyl 6-broMo-2-Methoxynicotinate Chemical Properties,Usage,Production

Synthesis

1060806-62-3

74-88-4

1009735-24-3

Step 2: Synthesis of methyl 6-bromo-2-methoxynicotinate; To N,N-dimethylformamide (10 mL), potassium carbonate (1.34 g, 9.48 mmol), 6-bromo-2-methoxynicotinic acid (1.10 g, 4.74 mmol), and iodomethane (0.895 g, 6.31 mmol) were added sequentially. The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the reaction mixture was diluted with water and ethyl acetate and the organic and aqueous layers were separated. The aqueous layer was extracted twice with ethyl acetate. All organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated. The concentrate was purified by silica gel column chromatography using 5%-10% ethyl acetate/heptane gradient elution to afford methyl 6-bromo-2-methoxynicotinate as a colorless oil (0.459 g, 40% yield).1H NMR (500 MHz, DMSO-d6) δppm3.81 (3H, s), 3.93 (3H, s), 7.36 (1H, d, J = 7.8 Hz), 8.06 (1H, d, J = 7.8 Hz).

References

[1] Patent: WO2010/116282, 2010, A1. Location in patent: Page/Page column 60
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 10, p. 4273 - 4288

Methyl 6-broMo-2-Methoxynicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 6-broMo-2-Methoxynicotinate Suppliers

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1009735-24-3, Methyl 6-broMo-2-MethoxynicotinateRelated Search:

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Methyl 6-broMo-2-Methoxynicotinate

3-Pyridinecarboxylic acid, 6-bromo-2-methoxy-, methyl ester

6-bromo-2-methoxynicotinic acid methyl ester

methyl 6-bromo-2-methoxy-pyridine-3-carboxylate

1009735-24-3