2-Fluoro-3-hydroxypyridine
- Product Name
- 2-Fluoro-3-hydroxypyridine
- CAS No.
- 174669-74-0
- Chemical Name
- 2-Fluoro-3-hydroxypyridine
- Synonyms
- 2-Fluoropyridin-3-ol;CAS:174669-74-0;2-Fluoro-3-pyridinol;2-Fluoro-3-hydroxypy;2-FLUOROPYRIDINE-3-OL;3-Pyridinol, 2-fluoro-;2-Fluoro-3-hydroxytyrosine;3-FLUORO-2-HYDROXYPYRIDINE;3-fluoro-2-hdyroxypyridine;2-FLUORO-3-HYDROXYPYRIDINE
- CBNumber
- CB5367690
- Molecular Formula
- C5H4FNO
- Formula Weight
- 113.09
- MOL File
- 174669-74-0.mol
2-Fluoro-3-hydroxypyridine Property
- Melting point:
- 131-133°C
- Boiling point:
- 306.7±22.0 °C(Predicted)
- Density
- 1.325±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO, Methanol
- pka
- 4.92±0.10(Predicted)
- form
- Solid
- color
- Pale Yellow
- CAS DataBase Reference
- 174669-74-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-37
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F0886
- Product name
- 2-Fluoro-3-hydroxypyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $130
- Updated
- 2025/07/31
- Product number
- F0886
- Product name
- 2-Fluoro-3-hydroxypyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $440
- Updated
- 2025/07/31
- Product number
- F591920
- Product name
- 2-Fluoro-3-hydroxypyridine
- Packaging
- 10g
- Price
- $690
- Updated
- 2021/12/16
- Product number
- 4H01-3-08
- Product name
- 2-Fluoro-3-hydroxypyridine
- Packaging
- 100g
- Price
- $464
- Updated
- 2021/12/16
- Product number
- PC01476
- Product name
- 2-Fluoro-3-hydroxypyridine
- Packaging
- 100g
- Price
- $290
- Updated
- 2021/12/16
2-Fluoro-3-hydroxypyridine Chemical Properties,Usage,Production
Chemical Properties
Light yellow Cryst
Uses
A pyridine derivative used in the preparation of imaging agents for nicotinic α4β2 receptor.
Uses
As a pyridine derivative, 2-Fluoro-3-hydroxypyridine can be used in the preparation of imaging agents for nicotinic α4β2 receptor.
Synthesis
16867-03-1
174669-74-0
100 mL of pyridine hydrofluoride (Py-(HF)x, 70% hydrogen fluoride and 30% pyridine, purchased from Fluka) was cooled at 0°C. 3.7 g of 2-amino-3-hydroxypyridine (molecular weight: 110.12, 33.6 mmol) and 3 g of NaNO2 (molecular weight: 69.00, 43.5 mmol) were added to it in sequence, handling with caution. The reaction mixture was stirred at 0 °C for 1 h, followed by slow alkalinization with 10 N NaOH aqueous solution. The mixture was transferred to a partition funnel and extracted with EtOAc. The organic phases were combined, washed sequentially with water and brine, dried over Na2SO4 and concentrated to dryness. The residue was purified by silica gel column chromatography (eluent: heptane/EtOAc, 50/50) to give 2.5 g (65% yield) of solid 2-fluoro-3-hydroxypyridine, which did not require further purification. Thin layer chromatography (TLC) Rf value (EtOAc/heptane, 80/20): 0.65. melting point: 131 °C. 1H NMR (DMSO-d6, 298 K): δ 10.41 (s, 1H), 7.64 (td, J=1.7 and 4.7 Hz, 1H), 7.42 (dd, J=1.7,1.7 and 10.8 Hz, 1H). 7.17 (ddd, J=1.3,4.7 and 7.8 Hz, 1H).13C NMR (DMSO-d6, 298K): δ 152.8 (d, J1F-C=233 Hz, C), 140.2 (d, J2F-C=27 Hz, C), 135.6 (d, J3F-C=13 Hz, CH), 126.2 (d, J3F -C=5 Hz, CH), 122.6 (CH). Mass spectrum (DCI/NH4+): C5H4FNO: 131 [M+NH4+], 114 [M+H+]. Elemental analysis (C5H4FNO) is consistent with theoretical values for C, H, and N.
References
[1] Patent: US2005/249662, 2005, A1. Location in patent: Page/Page column 8-9
[2] Journal of Labelled Compounds and Radiopharmaceuticals, 1998, vol. 41, # 5, p. 451 - 463
[3] Journal of Labelled Compounds and Radiopharmaceuticals, 2008, vol. 51, # 9, p. 336 - 342
[4] Patent: US2010/29650, 2010, A1. Location in patent: Page/Page column 64
[5] Organic and Biomolecular Chemistry, 2015, vol. 13, # 12, p. 3667 - 3676
2-Fluoro-3-hydroxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoro-3-hydroxypyridine manufacturers
- Product
- 2-Fluoro-3-hydroxypyridine 174669-74-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- 2-Fluoro-3-hydroxypyridine 174669-74-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-24
- Product
- 2-Fluoro-3-hydroxypyridine 174669-74-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10