2,6-Dichloro-7-methylpurine

Product Name: 2,6-Dichloro-7-methylpurine
CAS No.: 2273-93-0
Chemical Name: 2,6-Dichloro-7-methylpurine
Synonyms: 2,6-DICHLORO-7-METHYL-7H-PURINE;106282;2,6-DICHLORO-7-METHYLPURINE;2,6-dichloro-7-methyl-purin;7H-Purine, 2,6-dichloro-7-methyl-;2,6-Dichloro-7-methyl-7h-purine ,98%;2,6-DICHLORO-7-METHYLPURINE 97% (HPLC);7H-Purine,2,6-dichloro-7-methyl，97% min;2,6-DICHLORO-7-METHYLPURINE (2,6DCl7MeP)
CBNumber: CB6246923
Molecular Formula: C6H4Cl2N4
Formula Weight: 203.03
MOL File: 2273-93-0.mol

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2,6-Dichloro-7-methylpurine Property

Melting point:: 195.5-196 °C
Boiling point:: 307.2±52.0 °C(Predicted)
Density: 1.76±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -2.04±0.30(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 2273-93-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: D435240
Product name: 2,6-DICHLORO-7-METHYLPURINE
Packaging: 5g
Price: $800
Updated: 2021/12/16

TRC

Product number: D435240
Product name: 2,6-DICHLORO-7-METHYLPURINE
Packaging: 10g
Price: $1485
Updated: 2021/12/16

AK Scientific

Product number: J99325
Product name: 2,6-Dichloro-7-methylpurine
Packaging: 1g
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 011007
Product name: 2,6-Dichloro-7-methyl-7H-purine
Packaging: 1g
Price: $81
Updated: 2021/12/16

Biosynth Carbosynth

Product number: ND29030
Product name: 2,6-Dichloro-7-methylpurine
Packaging: 25mg
Price: $97.5
Updated: 2021/12/16

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2,6-Dichloro-7-methylpurine Chemical Properties,Usage,Production

Uses

2,6-DICHLORO-7-METHYLPURINE is used in the preparation and discover of novel mTOR INHIBITORS.

Synthesis

5451-40-1

74-88-4

2382-10-7

2273-93-0

A reaction was carried out in acetonitrile (200 mL) in the presence of potassium carbonate (1.2 eq., 4.39 g) with 2,6-dichloropurine (5.0 g, 1.0 eq.) and iodomethane (1.1 eq., 1.81 mL). The reaction mixture was stirred at 20 °C for 70 hours. After completion of the reaction, the solvent was removed by rotary evaporator. The crude product was separated by column chromatography (eluent: dichloromethane/methanol, 90/10, v/v) to afford 2,6-dichloro-9-methyl-9H-purine (3.55 g, 66% yield) and 2,6-dichloro-7-methylpurine (1.61 g, 30% yield).

References

[1] Patent: WO2005/28479, 2005, A2. Location in patent: Page/Page column 58
[2] Patent: US2011/86841, 2011, A1. Location in patent: Page/Page column 25
[3] Patent: WO2016/115434, 2016, A1. Location in patent: Page/Page column 222; 223
[4] Patent: WO2010/34707, 2010, A1. Location in patent: Page/Page column 15
[5] Patent: US2011/251217, 2011, A1. Location in patent: Page/Page column 6-7

2,6-Dichloro-7-methylpurine Preparation Products And Raw materials

Raw materials

2,6-Dichloropurine Acetonitrile Potassium carbonate Dichloromethane Methanol Tetrabutylammonium fluoride Iodomethane

Preparation Products

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2,6-Dichloro-7-methylpurine Suppliers

China 83 Germany 3 India 3 Russia 2 Switzerland 2 United Kingdom 7 United States 21 Global 121

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2273-93-0, 2,6-Dichloro-7-methylpurineRelated Search:

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106282

2,6-Dichloro-7-methyl-7h-purine ,98%

2,6-DICHLORO-7-METHYLPURINE

2,6-DICHLORO-7-METHYL-7H-PURINE

7H-Purine, 2,6-dichloro-7-methyl-

2,6-dichloro-7-methyl-purin

2,6-DICHLORO-7-METHYLPURINE 97% (HPLC)

2,6-DICHLORO-7-METHYLPURINE (2,6DCl7MeP)

7H-Purine,2,6-dichloro-7-methyl，97% min

2273-93-0

C6H4Cl2N4