ChemicalBook > CAS DataBase List > 2,6-Dichloro-7-methylpurine

2,6-Dichloro-7-methylpurine

Product Name
2,6-Dichloro-7-methylpurine
CAS No.
2273-93-0
Chemical Name
2,6-Dichloro-7-methylpurine
Synonyms
2,6-DICHLORO-7-METHYL-7H-PURINE;106282;2,6-DICHLORO-7-METHYLPURINE;2,6-dichloro-7-methyl-purin;7H-Purine, 2,6-dichloro-7-methyl-;2,6-Dichloro-7-methyl-7h-purine ,98%;2,6-DICHLORO-7-METHYLPURINE 97% (HPLC);7H-Purine,2,6-dichloro-7-methyl，97% min;2,6-DICHLORO-7-METHYLPURINE (2,6DCl7MeP)
CBNumber
CB6246923
Molecular Formula
C6H4Cl2N4
Formula Weight
203.03
MOL File
2273-93-0.mol
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2,6-Dichloro-7-methylpurine Property

Melting point:
195.5-196 °C
Boiling point:
307.2±52.0 °C(Predicted)
Density 
1.76±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-2.04±0.30(Predicted)
Appearance
White to off-white Solid
CAS DataBase Reference
2273-93-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
D435240
Product name
2,6-DICHLORO-7-METHYLPURINE
Packaging
5g
Price
$800
Updated
2021/12/16
TRC
Product number
D435240
Product name
2,6-DICHLORO-7-METHYLPURINE
Packaging
10g
Price
$1485
Updated
2021/12/16
Biosynth Carbosynth
Product number
ND29030
Product name
2,6-Dichloro-7-methylpurine
Packaging
500mg
Price
$950
Updated
2021/12/16
AK Scientific
Product number
J99325
Product name
2,6-Dichloro-7-methylpurine
Packaging
1g
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
ND29030
Product name
2,6-Dichloro-7-methylpurine
Packaging
200mg
Price
$500
Updated
2021/12/16
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2,6-Dichloro-7-methylpurine Chemical Properties,Usage,Production

Uses

2,6-DICHLORO-7-METHYLPURINE is used in the preparation and discover of novel mTOR INHIBITORS.

Synthesis

5451-40-1

74-88-4

2382-10-7

2273-93-0

A reaction was carried out in acetonitrile (200 mL) in the presence of potassium carbonate (1.2 eq., 4.39 g) with 2,6-dichloropurine (5.0 g, 1.0 eq.) and iodomethane (1.1 eq., 1.81 mL). The reaction mixture was stirred at 20 °C for 70 hours. After completion of the reaction, the solvent was removed by rotary evaporator. The crude product was separated by column chromatography (eluent: dichloromethane/methanol, 90/10, v/v) to afford 2,6-dichloro-9-methyl-9H-purine (3.55 g, 66% yield) and 2,6-dichloro-7-methylpurine (1.61 g, 30% yield).

References

[1] Patent: WO2005/28479, 2005, A2. Location in patent: Page/Page column 58
[2] Patent: US2011/86841, 2011, A1. Location in patent: Page/Page column 25
[3] Patent: WO2016/115434, 2016, A1. Location in patent: Page/Page column 222; 223
[4] Patent: WO2010/34707, 2010, A1. Location in patent: Page/Page column 15
[5] Patent: US2011/251217, 2011, A1. Location in patent: Page/Page column 6-7

2,6-Dichloro-7-methylpurine Preparation Products And Raw materials

Raw materials

2,6-Dichloropurine Acetonitrile Potassium carbonate Dichloromethane Methanol Tetrabutylammonium fluoride Iodomethane

Preparation Products

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2273-93-0, 2,6-Dichloro-7-methylpurineRelated Search:

Dichloromethylsilane 2,6-Dichloropurine 2-Chloro-5-chloromethylpyridine Methyl acrylate Methyl acetate Methylparaben Dichlorodimethylsilane Purine Bensulfuron methyl Dichloromethylphenylsilane Kresoxim-methyl Thiophanate-methyl 6-O-Methyl-guanine Methyl Parathion-methyl Methyl bromide 2-Chloropyrimidine 2-Chloropurine

  • 106282
  • 2,6-Dichloro-7-methyl-7h-purine ,98%
  • 2,6-DICHLORO-7-METHYLPURINE
  • 2,6-DICHLORO-7-METHYL-7H-PURINE
  • 7H-Purine, 2,6-dichloro-7-methyl-
  • 2,6-dichloro-7-methyl-purin
  • 2,6-DICHLORO-7-METHYLPURINE 97% (HPLC)
  • 2,6-DICHLORO-7-METHYLPURINE (2,6DCl7MeP)
  • 7H-Purine,2,6-dichloro-7-methyl，97% min
  • 2273-93-0
  • C6H4Cl2N4