1-Boc-hexahydro-1,4-diazepine
- Product Name
- 1-Boc-hexahydro-1,4-diazepine
- CAS No.
- 112275-50-0
- Chemical Name
- 1-Boc-hexahydro-1,4-diazepine
- Synonyms
- TERT-BUTYL 1,4-DIAZEPANE-1-CARBOXYLATE;1-BOC-HOMOPIPERAZINE;HPBOC;BOC-HOPIZ;BOC-HOPAZ;Boc-HomoPiz;Boc-HoPaz*HCl;Boc-HoPiz, liq.;BUTTPARK 27\08-71;BOC-HOMOPIPERAZINE
- CBNumber
- CB8230427
- Molecular Formula
- C10H20N2O2
- Formula Weight
- 200.28
- MOL File
- 112275-50-0.mol
1-Boc-hexahydro-1,4-diazepine Property
- Melting point:
- 143.4 °C
- Boiling point:
- 95-110 °C0.5 mm Hg(lit.)
- Density
- 1.016 g/mL at 20 °C(lit.)
- refractive index
- n20/D 1.471(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 10.45±0.20(Predicted)
- form
- Liquid
- Specific Gravity
- 1.016
- color
- Colorless to yellow
- Water Solubility
- Not miscible or difficult to mix in water.
- Sensitive
- Air Sensitive
- BRN
- 7581789
- CAS DataBase Reference
- 112275-50-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 511382
- Product name
- 1-Boc-hexahydro-1,4-diazepine
- Purity
- 98%
- Packaging
- 5g
- Price
- $131
- Updated
- 2024/03/01
- Product number
- L17728
- Product name
- 1-Boc-homopiperazine, 98%
- Packaging
- 1g
- Price
- $44.65
- Updated
- 2024/03/01
- Product number
- L17728
- Product name
- 1-Boc-homopiperazine, 98%
- Packaging
- 5g
- Price
- $117.65
- Updated
- 2024/03/01
- Product number
- B656175
- Product name
- 1-Boc-hexahydro-1,4-diazepine
- Packaging
- 2g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- 265573
- Product name
- Boc-homopiperazine
- Packaging
- 2g
- Price
- $333
- Updated
- 2021/12/16
1-Boc-hexahydro-1,4-diazepine Chemical Properties,Usage,Production
Chemical Properties
Colorless to yellow liquid
Uses
1-Boc-hexahydro-1,4-diazepine is a diazepine derivative used in the preparation of pharmaceutical compounds such as histamine H3-receptor antagonists and dipeptidyl peptidase IV (DPP-IV) inhibitors.
Uses
1-Boc-homopiperazine is used in synthesis of potent anticoagulant. It is also used to produce 4-(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester by reaction with 11-bromo-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline.
General Description
1-Boc-hexahydro-1,4-diazepine is an N-boc protected homopiperazine. Its enthalpy of vaporization at boiling point (558.15K) is 49.498kjoule/mol.
Synthesis
To a solution of di-tert-butyldicarbonate (2.201 g, 9.780 mmol) in acetic acid (9.8 mL), a solution of 1,4-diazepane (1.0 g, 9.780 mmol) in acetic acid (9.8 mL) is added at room temperature. After 24 hours, water is added and the pH is adjusted to 10 using 10% NaOH. The aqueous phase is then extracted with dichloromethane (2 x 15 mL). The organic phase is dried and the solvent is evaporated to obtain tert-butyl 1,4-diazepane-1-carboxylate (1-Boc-hexahydro-1,4-diazepine) with a yield of 90.0%.
Precautions
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. It is sensitive to air.
References
Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity. Bioorganic &Medicinal Chemistry. 2004, 12 (9), 2179-2191.
Discovery and structure-activity relationship of thienopyridine derivatives as bone anabolic agents. Bioorganic & medicinal chemistry. 2013, 21 (7), 1628-1642.
1-Boc-hexahydro-1,4-diazepine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Boc-hexahydro-1,4-diazepine manufacturers
- Product
- 1-Boc-hexahydro-1,4-diazepine 112275-50-0
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-24