1-N-Boc-5-oxo-1,4-diazepane
- Product Name
- 1-N-Boc-5-oxo-1,4-diazepane
- CAS No.
- 190900-21-1
- Chemical Name
- 1-N-Boc-5-oxo-1,4-diazepane
- Synonyms
- ic Acid Tert-ButyL;N-Boc-1,4-diazepan-5-one;1-Boc-1,4-diazepan-5-one;N1-BOC-5-oxo-1,4-diazepane;1-N-Boc-5-oxo-1,4-Diazepane;5-Oxo-[1,4]Diazepane-1-CarboxyL;1,4-Diazepan-5-one, N1-Boc protected;Homopiperazin-5-one, N1-BOC protected;tert-Butyl-5-oxo-1,4-diazepan-1-carboxylat;5-Oxo-[1,4]diazepane-1-carboxylic acid tert-butyl ester
- CBNumber
- CB3946990
- Molecular Formula
- C10H18N2O3
- Formula Weight
- 214.26
- MOL File
- 190900-21-1.mol
1-N-Boc-5-oxo-1,4-diazepane Property
- Boiling point:
- 373.1±35.0 °C(Predicted)
- Density
- 1.098±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 16.06±0.20(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C10H18N2O3/c1-10(2,3)15-9(14)12-6-4-8(13)11-5-7-12/h4-7H2,1-3H3,(H,11,13)
- InChIKey
- GLJYPTWEXBUATJ-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(=O)NCC1
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B809625
- Product name
- tert-Butyl5-Oxo-1,4-diazepane-1-carboxylate
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- J99688
- Product name
- 5-Oxo-[1,4]diazepane-1-carboxylicacidtert-butylester
- Packaging
- 10g
- Price
- $260
- Updated
- 2021/12/16
- Product number
- W4101
- Product name
- 5-Oxo-[1,4]diazepane-1-carboxylicacidtert-butylester
- Packaging
- 5g
- Price
- $214
- Updated
- 2021/12/16
- Product number
- 040980
- Product name
- tert-Butyl 5-oxo-1,4-diazepane-1-carboxylate
- Packaging
- 500mg
- Price
- $33
- Updated
- 2021/12/16
- Product number
- FB140301
- Product name
- tert-Butyl 5-oxo-1,4-diazepane-1-carboxylate
- Packaging
- 2g
- Price
- $140
- Updated
- 2021/12/16
1-N-Boc-5-oxo-1,4-diazepane Chemical Properties,Usage,Production
Uses
1-N-Boc-5-oxo-1,4-diazepane is a 1,4-diazepane derivatives compound，used as sigma receptor ligands in antipsychotics, antiamnesics, and against other neurodegenerative disorders as well as neuroprotective agents.[1]
Synthesis
150008-24-5
190900-21-1
The general procedure for the synthesis of N-Boc-1,4-diaza-5-cycloheptanone from 4-oxime-1-Boc-piperidine was as follows: to a solution of tetrahydrofuran (THF, 10 mL) containing the ketoxime (0.01 mol) was added T3P (15 mol%, 50% solution in ethyl acetate). The reaction mixture was stirred at reflux for 1-4 h under nitrogen protection. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the solvent was removed under reduced pressure. The residue was diluted with distilled water (20 mL) and subsequently extracted with ethyl acetate (2 x 20 mL). The organic phases were combined and washed sequentially with saturated sodium bicarbonate (NaHCO3) solution (1 × 10 mL) and brine. The organic phase was dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give a high purity target amide product.
References
[1] Daniele Zampieri*. “Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands.” ACS Medicinal Chemistry Letters 11 5 (2019): 651–656.
1-N-Boc-5-oxo-1,4-diazepane Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-N-Boc-5-oxo-1,4-diazepane manufacturers
- Product
- tert-Butyl-5-oxo-1,4-diazepan-1-carboxylat 190900-21-1
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1kg,5kg,50kg
- Release date
- 2020-01-18