ChemicalBook > CAS DataBase List > 1-N-Boc-5-oxo-1,4-diazepane

1-N-Boc-5-oxo-1,4-diazepane

Product Name
1-N-Boc-5-oxo-1,4-diazepane
CAS No.
190900-21-1
Chemical Name
1-N-Boc-5-oxo-1,4-diazepane
Synonyms
ic Acid Tert-ButyL;N-Boc-1,4-diazepan-5-one;1-Boc-1,4-diazepan-5-one;N1-BOC-5-oxo-1,4-diazepane;1-N-Boc-5-oxo-1,4-Diazepane;5-Oxo-[1,4]Diazepane-1-CarboxyL;1,4-Diazepan-5-one, N1-Boc protected;Homopiperazin-5-one, N1-BOC protected;tert-Butyl-5-oxo-1,4-diazepan-1-carboxylat;5-Oxo-[1,4]diazepane-1-carboxylic acid tert-butyl ester
CBNumber
CB3946990
Molecular Formula
C10H18N2O3
Formula Weight
214.26
MOL File
190900-21-1.mol
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1-N-Boc-5-oxo-1,4-diazepane Property

Boiling point:
373.1±35.0 °C(Predicted)
Density 
1.098±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
16.06±0.20(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C10H18N2O3/c1-10(2,3)15-9(14)12-6-4-8(13)11-5-7-12/h4-7H2,1-3H3,(H,11,13)
InChIKey
GLJYPTWEXBUATJ-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(=O)NCC1
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Safety

HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B809625
Product name
tert-Butyl5-Oxo-1,4-diazepane-1-carboxylate
Packaging
500mg
Price
$130
Updated
2021/12/16
AK Scientific
Product number
J99688
Product name
5-Oxo-[1,4]diazepane-1-carboxylicacidtert-butylester
Packaging
10g
Price
$260
Updated
2021/12/16
AK Scientific
Product number
W4101
Product name
5-Oxo-[1,4]diazepane-1-carboxylicacidtert-butylester
Packaging
5g
Price
$214
Updated
2021/12/16
Matrix Scientific
Product number
040980
Product name
tert-Butyl 5-oxo-1,4-diazepane-1-carboxylate
Packaging
500mg
Price
$33
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140301
Product name
tert-Butyl 5-oxo-1,4-diazepane-1-carboxylate
Packaging
2g
Price
$140
Updated
2021/12/16
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1-N-Boc-5-oxo-1,4-diazepane Chemical Properties,Usage,Production

Uses

1-N-Boc-5-oxo-1,4-diazepane is a 1,4-diazepane derivatives compound，used as sigma receptor ligands in  antipsychotics, antiamnesics, and against other neurodegenerative disorders as well as neuroprotective agents.[1]

Synthesis

150008-24-5

190900-21-1

The general procedure for the synthesis of N-Boc-1,4-diaza-5-cycloheptanone from 4-oxime-1-Boc-piperidine was as follows: to a solution of tetrahydrofuran (THF, 10 mL) containing the ketoxime (0.01 mol) was added T3P (15 mol%, 50% solution in ethyl acetate). The reaction mixture was stirred at reflux for 1-4 h under nitrogen protection. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the solvent was removed under reduced pressure. The residue was diluted with distilled water (20 mL) and subsequently extracted with ethyl acetate (2 x 20 mL). The organic phases were combined and washed sequentially with saturated sodium bicarbonate (NaHCO3) solution (1 × 10 mL) and brine. The organic phase was dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give a high purity target amide product.

References

[1] Daniele Zampieri*. “Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands.” ACS Medicinal Chemistry Letters 11 5 (2019): 651–656.

1-N-Boc-5-oxo-1,4-diazepane Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-N-Boc-5-oxo-1,4-diazepane manufacturers

Career Henan Chemical Co
Product
tert-Butyl-5-oxo-1,4-diazepan-1-carboxylat 190900-21-1
Price
US $3.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1kg,5kg,50kg
Release date
2020-01-18

190900-21-1, 1-N-Boc-5-oxo-1,4-diazepaneRelated Search:

BUTYL OLEATE Cyclohexanone Methyl acrylate Cyhalofop-butyl tert-Butyl carbazate Tris(trimethylsilyl)phosphate 17alpha-Ethynyl-19-nortestosterone 17-heptanoate Cycloheptanone Butyl acetate Buprofezin D-MANNOHEPTULOSE 6-Methyl-5-hepten-2-one DBU 1-Boc-hexahydro-1,4-diazepine 2,3,6,7-Tetrahydro-(1H)-1,4-diazepin-5(4H)-one 2,5-Diaza-5-methylcycloheptanone 1-N-Boc-5-oxo-1,4-diazepane 1-Boc-5-oxo-1,4-diazepane

  • tert-Butyl-5-oxo-1,4-diazepan-1-carboxylat
  • Homopiperazin-5-one, N1-BOC protected
  • 1-N-Boc-5-oxo-1,4-Diazepane
  • N1-BOC-5-oxo-1,4-diazepane
  • 1H-1,4-diazepine-1-carboxylic acid, hexahydro-5-oxo-, 1,1-
  • 5-Oxo-[1,4]diazepane-1-carboxylic acid tert-butyl ester
  • 1-Boc-1,4-diazepan-5-one
  • 1,4-Diazepan-5-one, N1-Boc protected
  • 5-Oxo-[1,4]Diazepane-1-CarboxyL
  • ic Acid Tert-ButyL
  • N-Boc-1,4-diazepan-5-one
  • 190900-21-1